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Clozapine

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Identification
Molecular formula
C18H19ClN4
CAS number
5786-21-0
IUPAC name
2-chloro-5-methyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine
State
State

At room temperature, clozapine is typically in a solid state.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
531.90
Boiling point (Kelvin)
805.05
General information
Molecular weight
326.83g/mol
Molar mass
326.8280g/mol
Density
1.2805g/cm3
Appearence

Clozapine appears as a pale yellow to yellow crystalline powder. Due to its structure, it can sometimes also appear as a powder with off-white tones. The compound is slightly soluble in water and freely soluble in dimethyl sulfoxide (DMSO) and ethanol.

Comment on solubility

Solubility of 2-chloro-5-methyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine

The solubility of 2-chloro-5-methyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine can be quite complex due to its unique chemical structure. Understanding its solubility is essential for various applications, especially in pharmacology.

Here are several key factors affecting its solubility:

  • Polarity: The compound is likely to exhibit low polarity, which can limit its solubility in polar solvents such as water.
  • Solvent Interaction: It may dissolve better in organic solvents like ethanol or DMSO due to the hydrophobic parts of its structure.
  • Temperature Influence: Increasing temperature can enhance solubility, leading to increased dissolution rates.
  • pH Dependency: The solubility may vary with changes in pH, particularly if the compound contains ionizable groups.

As a general guideline, compounds like this are often more soluble in non-polar to slightly polar solvents. It is crucial to conduct empirical tests to determine the precise solubility characteristics.
Ultimately, the unique structure of 2-chloro-5-methyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine may result in a solubility profile that is specific to its intended application.

Interesting facts

Interesting Facts about 2-Chloro-5-methyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine

This intriguing compound belongs to the benzodiazepine class and exhibits a complex structure that adds to its unique characteristics.

Key Features

  • Structural Complexity: The presence of both isoquinoline and benzodiazepine structures makes this compound particularly interesting for synthetic chemists.
  • Biological Activity: Like many compounds in its class, it may interact with GABA receptors, though its specific pharmacological profiles are an active area of research.
  • Potential Applications: Compounds similar to this are often investigated for their potential as anxiolytics, sedatives, or anticonvulsants, which has driven extensive studies in medicinal chemistry.

Did You Know?

Here are some fascinating insights:

  • Synthesis Routes: The synthesis of 2-chloro-5-methyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine typically involves multiple steps, including cyclization and functionalization reactions, showcasing the skill required in organic synthesis.
  • Research Potential: Ongoing studies are being conducted to explore its effects on the central nervous system, highlighting its importance in the field of neuroscience.

Additionally, the compound's chloro substituent can significantly affect its reactivity and biological interactions, making it a point of interest in drug design and development. The interconnectedness of its chemical properties with biological outcomes underscores the vital role of structural variations in pharmacology.

In summary, the multifaceted nature of 2-chloro-5-methyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine reflects the dynamic field of medicinal chemistry, inviting further exploration into its potential therapeutic applications.

Synonyms
2-Chloro-5,6,7,9,10,14b-hexahydro-5-methylisoquino[2,1-d][1,4]benzodiazepine
2-Chloro-5,6,7,9,10,14B-hexahydro-5-methylisoquino(2,1-D)(1,4)benzodiazepine
668-119-6
17617-11-7
BRN 0683598
2-Chloro-5-methyl-6,7,9,10-tetrahydro-5H-isoquino(2,1-d)(1,4)benzodiazepine
2-chloro-5-methyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine
2-chloro-5-methyl-5,6,7,9,10,14b-hexahydroisoquino[2,1-d][1,4]benzodiazepine
48187-65-1
D-2-Chloro-5-methyl-6,7,9,10-tetrahydro-5H-isoquino(2,1-d)(1,4)benzodiazepine
ISOQUINO(2,1-d)(1,4)BENZODIAZEPINE, 5,6,7,9,10,14b-HEXAHYDRO-2-CHLORO-5-METHYL-
Isoquino(2,1-d)(1,4)benzodiazepine, 5,6,7,9,10,14b-hexahydro-2-chloro-5-methyl-, D-
Isoquino(2,1-d)(1,4)benzodiazepine, 5,6,7,9,10,14b-hexahydro-2-chloro-5-methyl-, L-
L-2-Chloro-5-methyl-6,7,9,10-tetrahydro-5H-isoquino(2,1-d)(1,4)benzodiazepine
47124-18-5
DTXSID10938764
AKOS024324336
TL-004/43519157
2-Chloro-5-methyl-5,6,7,9,10,14b-hexahydrobenzo[5,6][1,4]diazepino[7,1-a]isoquinoline
2-Chloro-5-methyl-5,6,7,9,10,14b-hexahydroisoquinolino[2,1-d][1,4]benzodiazepine
17656-72-3