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Clozapine

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Identification
Molecular formula
C18H19ClN4O
CAS number
5786-21-0
IUPAC name
2-chloro-5-methyl-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one
State
State
Clozapine is a solid at room temperature, typically consisting of a crystalline powder that is pale yellow in color.
Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
509.20
Boiling point (Kelvin)
782.35
General information
Molecular weight
326.83g/mol
Molar mass
326.8310g/mol
Density
1.3005g/cm3
Appearence

Clozapine typically appears as a pale yellow, crystalline powder. Its solid form means it can easily be measured and formulated for various pharmaceutical applications.

Comment on solubility

Solubility of 2-chloro-5-methyl-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one

When assessing the solubility of 2-chloro-5-methyl-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one, a few key factors come into play:

  • Polarity: This compound has a complex structure that may influence its polar characteristics. The presence of chlorine and the nitrogen atoms in the structure enhance its ability to interact with polar solvents.
  • Solvent Compatibility: Generally, compounds of this nature tend to be more soluble in organic solvents like dichloromethane or ethanol, while exhibiting limited solubility in water.
  • Functional Groups: The functionality of the benzodiazepine can lead to variations in solubility due to the potential for hydrogen bonding interactions.

As a general observation, the solubility of this compound can vary significantly depending on the solvent used:

  • Highly soluble in organic solvents due to nonpolar and polar characteristics.
  • Poorly soluble in water, limiting its application in aqueous environments.

In conclusion, while careful experimentation would yield definitive solubility values, the overall tendency is that this compound will favor solubility in organic mediums, an important consideration for its potential applications.

Interesting facts

Exploring 2-chloro-5-methyl-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one

This fascinating compound belongs to the class of benzodiazepines, which are renowned for their diverse pharmacological properties. Here are some intriguing aspects of this particular benzodiazepine derivative:

  • Structural Complexity: The compound features a unique fusion of isoquinoline and benzodiazepine structures, offering extensive opportunities for modifications and derivations that can lead to varied biological activity.
  • Medical Potential: Due to its structural characteristics, compounds in the benzodiazepine family typically exhibit anxiolytic, sedative, and anticonvulsant properties, making them invaluable in medical applications.
  • Synthetic Pathways: The synthesis of this compound often involves multiple steps that can include techniques such as cyclization and functionalization. Each synthetic route can significantly influence the compound's properties and yield.
  • Research Applications: Studies on compounds like this one facilitate advancements in drug discovery and help uncover new mechanisms of action in the neuropharmacology field.

In summary, 2-chloro-5-methyl-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one showcases a rich tapestry of chemical intrigue. As research continues, the full extent of its potential benefits could unlock new therapeutic avenues.

Synonyms
Clazolam
Isoquinazepon
7492-29-7
(+)-Clazolam
SAH-1123
10171-69-4
10243-45-5
2-chloro-5-methyl-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one
Clazolam, (-)-
GYR9E8U0NH
RV8R0M5NDC
NSC-339128
BRN 0760885
MLS003170948
NSC339128
2-Chloro-5,9,10,14b-tetrahydro-5-methylisoquino(2,1-d)(1,4)-benzodiazepin-6(7H)-one
2-Chloro-5-methyl-6,7,9,10-tetrahydro-5H-isoquino(2,1-d)(1,4)benzodiazepin-6-one
Isoquino(2,1-d)(1,4)benzodiazepin-6(7H)-one, 2-chloro-5,9,10,14b-tetrahydro-5-methyl-
YJ53T77095
NCGC00160595-01
Clazolomum
(+)-2-Chloro-5,9,10,14b-tetrahydro-5-methylisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one
Isoquino(2,1-d)(1,4)benzodiazepin-6(7H)-one, 5,9,10,14b-tetrahydro-2-chloro-5-methyl-
Clazolamum
Clazolam [USAN:INN]
Clazolamum [INN-Latin]
(-)-5,9,10,14b-Tetrahydro-2-chloro-5-methylisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one
NSC 339128
UNII-YJ53T77095
2-Chloro-5,9,10,14b-tetrahydro-5-methylisoquino[2,1-d][1,4]-benzodiazepin-6(7H)-one
Clazolam (+)
Clazolam (free base)
CLAZOLAM [USAN]
Clazolam (USAN/INN)
CLAZOLAM [INN]
UNII-GYR9E8U0NH
UNII-RV8R0M5NDC
2-Chlor-5,6,7,9,10,14b-hexahydro-5-methylisochino(2,1-d)(1,4)benzodiazepin-6-on [IUPAC]
D-2-Chloro-5-methyl-6,7,9,10-tetrahydro-5H-isoquino(2,1-d)(1,4)benzodiazepin-6-one
DSSTox_CID_26249
DSSTox_RID_81476
Isoquino(2,1-d)(1,4)benzodiazepin-6(7H)-one, 5,9,10,14b-tetrahydro-2-chloro-5-methyl-, D-
Isoquino(2,1-d)(1,4)benzodiazepin-6(7H)-one, 5,9,10,14b-tetrahydro-2-chloro-5-methyl-, L-
L-2-Chloro-5-methyl-6,7,9,10-tetrahydro-5H-isoquino(2,1-d)(1,4)benzodiazepin-6-one
DSSTox_GSID_46249
CLAZOLAM, (+)-
(+)-2-Chlor-5,9,10,14b-tetrahydro-5-methylisochino(2,1-d)(1,4)benzodiazepin-6(7H)-on [IUPAC]
SCHEMBL635419
CHEMBL1723823
DTXSID50274072
CHEBI:177528
YAQKGZXXQNKEET-UHFFFAOYSA-N
Tox21_111924
AKOS024324088
(+)-2-Chlor-5,9,10,14b-tetrahydro-5-methylisochino(2,1-d)(1,4)benzodiazepin-6(7H)-on
2-Chlor-5,6,7,9,10,14b-hexahydro-5-methylisochino(2,1-d)(1,4)benzodiazepin-6-on
SMR001874862
CAS-7492-29-7
NS00126819
D03531
WLN: T C6 B676 KN MVN&TT&J N1 RG
Q5130404
2-Chloro-5,10,14b-tetrahydro-5-methylisoquino[2,1-d][1,4]-benzodiazepin-6(7H)-one
2-Chloro-5,9,10,14b-tetrahydro-5-me-isoquino(2,1-d)(1,4)benzodiazepin-6(7H)-one
2-Chloro-5-methyl-5,9,10,14b-tetrahydroisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one
Isoquino(2,1-d)(1,4)benzodiazepin-6(5H)-one, 2-chloro-7,9,10,14b-tetrahydro-5-methyl-
Isoquino[2,4]benzodiazepin-6(5H)-one, 2-chloro-7,9,10,14b-tetrahydro-5-methyl-
Isoquino[2,4]benzodiazepin-6(7H)-one, 2-chloro-5,9,10,14b-tetrahydro-5-methyl-
Isoquino[2,4]benzodiazepin-6(7H)-one, 5,9,10,14b-tetrahydro-2-chloro-5-methyl-
(+)-2-Chloro-5-methyl-5,6,9,10-tetrahydro-(7H)-isoquinolino(2,1-d)-benzo(1,4)-diazepin-6-one
(+)-2-Chloro-5-methyl-5,9,10-tetrahydro-(7H)-isoquinolino[2,1-d]-benzo[1,4]-diazepin-6-one
ISOQUINO(2,1-D)(1,4)BENZODIAZEPIN-6(7H)-ONE, 2-CHLORO-5,9,10,14B-TETRAHYDRO-5-METHYL-, (+)-
ISOQUINO(2,1-D)(1,4)BENZODIAZEPIN-6(7H)-ONE, 2-CHLORO-5,9,10,14B-TETRAHYDRO-5-METHYL-, (-)-