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2-chloro-5-nitrobenzenesulfonyl chloride

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Identification
Molecular formula
C6H3Cl2NO4S
CAS number
68411-19-4
IUPAC name
2-chloro-5-nitro-benzenesulfonyl chloride
State
State

At room temperature, 2-chloro-5-nitrobenzenesulfonyl chloride is a solid. It typically exists in a crystalline powder form, making it relatively easy to handle for laboratory and industrial applications, as long as appropriate safety measures are followed to prevent moisture exposure.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
269.06g/mol
Molar mass
269.0610g/mol
Density
1.6770g/cm3
Appearence

2-Chloro-5-nitrobenzenesulfonyl chloride is a pale yellow to beige crystalline solid. It may appear as a powder or in crystalline form, and it is known for being somewhat sensitive to moisture, resulting in hydrolysis when exposed to water.

Comment on solubility

Solubility of 2-chloro-5-nitro-benzenesulfonyl chloride

The solubility of 2-chloro-5-nitro-benzenesulfonyl chloride is an intriguing aspect of this compound. Generally, its solubility can be influenced by several factors, including polarity, molecular structure, and the presence of functional groups. Here are some key points to consider:

  • Polarity: The presence of the sulfonyl chloride functional group enhances the polarity of the molecule, which often increases solubility in polar solvents.
  • Solvent Compatibility: This compound may dissolve well in polar aprotic solvents such as DMSO or DMF, but its solubility in water is likely limited due to the hydrophobic characteristics of the benzene ring.
  • Temperature Influence: Solubility can also vary with temperature; generally, increasing temperature can enhance solubility for many organic compounds.
  • Reaction Behavior: Notably, it is important to consider that 2-chloro-5-nitro-benzenesulfonyl chloride may participate in chemical reactions in solution, which could affect its apparent solubility.

In summary, while the specific solubility of 2-chloro-5-nitro-benzenesulfonyl chloride in various solvents may vary, its structural characteristics suggest a higher tendency for solubility in polar environments compared to non-polar ones. Conducting empirical solubility tests is advisable for practical applications.

Interesting facts

Interesting Facts about 2-Chloro-5-Nitro-Benzenesulfonyl Chloride

2-Chloro-5-nitro-benzenesulfonyl chloride, often referred to in scientific communities as a versatile chemical intermediate, plays a significant role in organic synthesis. Its unique functional groups offer numerous possibilities in the realm of chemical research and applications.

Key Features of 2-Chloro-5-nitro-benzenesulfonyl Chloride:

  • Reactivity: The chlorine and nitro groups present in the molecule make it highly reactive, which is advantageous in forming various derivatives and complexes.
  • Synthetic Utility: It is commonly used as a sulfonylating agent, enabling the introduction of sulfonyl groups into other organic compounds, which can enhance their biological activity.
  • Biological Significance: Compounds derived from this chemical have been explored for their potential pharmaceutical applications, including anti-cancer properties and the development of novel drugs.

This compound exemplifies the importance of functional group manipulation in designing new materials and medicines. It is often noted for its ability to facilitate transformations that contribute to the chemical diversity necessary in drug discovery. As stated in various literature, “The introduction of sulfonyl chlorides into synthetic routes can often lead to increased selectivity and efficiency in obtaining desired products.”

In conclusion, 2-chloro-5-nitro-benzenesulfonyl chloride serves as an essential tool in the arsenal of chemists, enabling them to unlock new pathways and applications in both industrial and academic settings. With its myriad of uses, this compound is a clear example of how intricately chemistry and innovation are intertwined.

Synonyms
2-Chloro-5-nitrobenzenesulfonyl chloride
4533-95-3
Benzenesulfonyl chloride, 2-chloro-5-nitro-
NSC 350627
EINECS 224-873-4
DTXSID1063510
DTXCID1040405
cozwqpzdkvivfs-uhfffaoysa-n
2-Chloro-5-nitrobenzene-1-sulfonyl chloride
2-CHLORO-5-NITROBENZENESULPHONYL CHLORIDE
MFCD00129813
FDZ3GSM63X
2-Chloro-5-nitro-benzenesulfonyl chloride
NSC-350627
NSC 350627;
2-chloro-5-nitrobenzene-1-sulphonyl chloride
2-chloro-5-nitrophenylsulfonyl chloride
UNII-FDZ3GSM63X
SCHEMBL452351
NSC350627
AKOS000115105
2-chloro-5-nitrobenzenesulfonylchloride
2-chloro-5nitrobenzenesulfonyl chloride
5-nitro-2-chlorobenzenesulfonylchloride
CS-W009302
PB42843
5-nitro-2-chlorobenzenesulfonyl chloride
2-chloro-5-nitrobenzene sulfonyl chloride
6-chloro-3-nitrobenzenesulphonyl chloride
BS-13913
SY101785
2-chloro-5-nitro benzene sulphonylchloride
2-Chloro-5-nitrobenzene-1-sulfonylchloride
DB-051295
2--Chloro-5-nitro benzene sulphonylchloride
NS00031523
Benzenesulphonyl chloride, 2-chloro-5-nitro-
EN300-01715
AA-516/25012170
Z56862360