2-Chloro-5-(trifluoromethyl)aniline

Identification

Molecular formula

C₇H₅ClF₃N

CAS number

367-21-5

IUPAC name

2-chloro-5-(trifluoromethyl)aniline

State

At room temperature, 2-Chloro-5-(trifluoromethyl)aniline is typically in a solid state. It is often stored in airtight containers to prevent exposure to moisture and light, which might degrade the compound.

Melting point (Celsius)

48.00

Melting point (Kelvin)

321.15

Boiling point (Celsius)

227.00

Boiling point (Kelvin)

500.15

General information

Molecular weight

179.57g/mol

Molar mass

179.5700g/mol

Density

1.3910g/cm³

Appearence

2-Chloro-5-(trifluoromethyl)aniline appears as a pale yellow crystalline solid. It may also appear as off-white to light beige powder depending on its purity and storage conditions.

Comment on solubility

Solubility of 2-chloro-5-(trifluoromethyl)aniline

2-chloro-5-(trifluoromethyl)aniline, with the chemical formula C₇H₅ClF₃N, exhibits interesting solubility characteristics due to its unique molecular structure. When evaluating the solubility of this compound, consider the following points:

Polar and Nonpolar Interactions: The presence of the trifluoromethyl group (-CF₃) contributes significant polarity, which affects its solubility in different solvents.
Aromatic Nature: As an aromatic compound, its solubility in water may be limited, yet it might dissolve well in organic solvents such as ethanol and acetone.
Hydrogen Bonding: The amino group (-NH₂) can form hydrogen bonds, enhancing its solubility in certain polar solvents.
Environmental Considerations: Due to the chlorine and fluorine substituents, solubility can vary significantly based on environmental conditions like temperature and pH.

In general, **2-chloro-5-(trifluoromethyl)aniline** is likely to be more soluble in organic solvents compared to water, highlighting the importance of molecular structure in determining solubility.

Interesting facts

Interesting Facts about 2-Chloro-5-(trifluoromethyl)aniline

2-Chloro-5-(trifluoromethyl)aniline is a fascinating compound that belongs to the class of aniline derivatives, which are known for their importance in both industrial and pharmaceutical applications. Here are some intriguing aspects of this compound:

Structure & Reactivity: The presence of both a chloro and a trifluoromethyl group in its structure greatly influences the compound's reactivity patterns. The trifluoromethyl group is highly electronegative, which can enhance the nucleophilicity of the aniline nitrogen, making it a valuable intermediate in organic transformations.
Use in Synthesis: This compound serves as an essential building block in the synthesis of various pharmaceuticals. Its unique functionalities allow chemists to create complex molecules that can lead to new therapeutic agents.
Environmental Considerations: Given the presence of fluorine atoms, compounds that contain trifluoromethyl groups can exhibit increased stability and resistance to degradation. This makes understanding their environmental impact crucial as they may persist longer in ecosystems.
Regulatory Status: As with many halogenated compounds, there is an ongoing evaluation of the safety and environmental impact of 2-chloro-5-(trifluoromethyl)aniline. Researchers are keen to study its toxicity levels and biocompatibility to ensure responsible use.
Applications Beyond Pharmaceuticals: Beyond its role in drug synthesis, this compound may find applications in materials science, particularly in the development of novel polymers that exhibit unique properties due to the incorporation of the trifluoromethyl group.

In conclusion, 2-chloro-5-(trifluoromethyl)aniline is more than just a derivative of aniline. Its unique structure and reactivity position it as a valuable compound in various scientific disciplines. As researchers continue to explore the properties and potential applications of this compound, its significance in both chemistry and industrial processes is likely to expand further.

Synonyms

3-Amino-4-chlorobenzotrifluoride

121-50-6

2-Chloro-5-(trifluoromethyl)aniline

2-Chloro-5-trifluoromethylaniline

Benzenamine, 2-chloro-5-(trifluoromethyl)-

Fast Orange Salt RD

Orange Salt NRD

Daito Orange Salt RD

Diazo Fast Orange RD

Fast Orange Salt RDA

Fast Orange Salt RDN

Fast Orange RD Salt

Sanyo Fast Orange Salt RD

4-Chloro-3-aminobenzotrifluoride

Azoene Fast Orange RD Salt

USAF MA-13

Hiltosal Fast Orange RD Salt

6-Chloro-3-(trifluoromethyl)aniline

NSC 10318

C.I. 37050

CCRIS 2816

6-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine

EINECS 204-475-7

BRN 0879910

AI3-26183

MFCD00007673

3-Amino-4-chloro-alpha,alpha,alpha-trifluorotoluene

m-TOLUIDINE, 6-CHLORO-alpha,alpha,alpha-TRIFLUORO-

7XBP8297PJ

DTXSID1059525

4-12-00-01852 (Beilstein Handbook Reference)

NSC-10318

EN300-18346

m-Toluidine, 6-chloro-.alpha.,.alpha.,.alpha.-trifluoro-

2-chloro-5-(trifluoromethyl)benzenamine

2-chloro-5-trifluoromethyl-phenylamine

WLN: ZR BG EXFFF

UNII-7XBP8297PJ

SCHEMBL330390

CHEMBL528932

DTXCID0033671

2-chloro-5-trifluoromethylanilin

BDBM626066

2-chloro-5-trifluoromethyl aniline

2-chloro-5-trifluoromethyl-aniline

NSC10318

STL281874

AKOS000119306

AC-3672

CS-W010614

PS-8282

A0948

NS00004820

D77708

6-Chloro-.alpha.,.alpha.-trifluoro-m-toluidine

3-Amino-4-chloro-.alpha.,.alpha.-trifluorotoluene

2-Chloro-5-(trifluoromethyl)aniline, >=98.0% (GC)

Z57117627

6-Chloro-.alpha.,.alpha.,.alpha.-trifluoro-m-toluidine

F5608-0076

3-Amino-4-chloro-.alpha.,.alpha.,.alpha.-trifluorotoluene

2-Chloro-5-trifluoromethylaniline;3-Amino-4-chlorobenzotrifluoride