Skip to main content

Clozapine

ADVERTISEMENT
Identification
Molecular formula
C18H19ClN4
CAS number
5786-21-0
IUPAC name
2-chloro-5,10-dimethyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine
State
State

At room temperature, clozapine exists as a solid.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
537.10
Boiling point (Kelvin)
810.25
General information
Molecular weight
326.83g/mol
Molar mass
326.8330g/mol
Density
1.2800g/cm3
Appearence

Clozapine appears as a pale yellow to yellow crystalline powder. It is practically insoluble in water, sparingly soluble in methanol and soluble in acetic acid and ethanol, which indicates that it requires specific solvents for dissolution and handling in laboratory settings.

Comment on solubility

Solubility of 2-chloro-5,10-dimethyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine

The solubility of 2-chloro-5,10-dimethyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine is influenced by several factors relating to its chemical structure and the surrounding environment. In general, this class of compounds tends to exhibit properties that can be summarized as follows:

  • Polar vs. Nonpolar: The presence of chlorine atoms and multiple methyl groups can contribute to a balance between polar and nonpolar characteristics, which can impact solubility in various solvents.
  • Solvent Selection: This compound is likely to have limited solubility in water due to its complex structure and potential hydrophobic regions, making organic solvents, such as ethanol or dimethyl sulfoxide (DMSO), more effective for dissolution.
  • Temperature Dependence: Solubility may increase with temperature, allowing for better dissolution in hot organic solvents compared to their cold counterparts.

Overall, while 2-chloro-5,10-dimethyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine may not be highly soluble in water, it's important to consider that its solubility behavior can vary significantly based on the environment in which it is placed. As emphasized in chemical studies, understanding the solubility of such compounds is crucial for developing formulations and achieving desired bioavailability in pharmaceutical applications.

Interesting facts

Interesting Facts about 2-Chloro-5,10-dimethyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine

2-Chloro-5,10-dimethyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine is a fascinating compound within the realm of organic chemistry, particularly due to its complex structure and potential applications. Below are some intriguing insights about this compound:

  • Pharmacological Interest: The unique structure of this compound suggests it may have significant pharmacological properties, particularly in the context of neurological disorders. Compounds within the benzodiazepine family are often explored for their sedative and anxiolytic effects.
  • Complex Structure: The intricate arrangement of fused rings contributes to its stability and potentially unique reactivity. The presence of a chlorine atom also hints at its possible reactivity patterns, opening up avenues for further chemical modifications.
  • Isoquinoline Framework: The isoquinoline skeleton is a notable feature that is known for various biological activities. Research has documented isoquinolines in various medicinal applications, including antibacterial and anti-inflammatory effects.
  • Synthesis Challenges: The synthesis of compounds of this complexity can be an elaborate process, often requiring multiple steps. Chemists often face challenges such as regioselectivity and stereochemistry, making this a captivating subject of study in synthetic organic chemistry.
  • Potential for Drug Development: Research continues on compounds similar to this one as they may serve as leads in drug development, specifically targeting receptors in the central nervous system.

In conclusion, the study of 2-chloro-5,10-dimethyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine offers an exciting glimpse into the interplay between chemical structure and biological function. As research progresses, the compound may shed light on novel therapeutic pathways and enhance our understanding of complex organic molecules.

Synonyms
19007-33-1
BRN 0686736
2-Chloro-5,10-dimethyl-6,7,9,10-tetrahydro-5H-isoquino(2,1-d)(1,4)benzodiazepine
Isoquino(2,1-d)(1,4)benzodiazepine, 5,6,7,9,10,14b-hexahydro-2-chloro-5,10-dimethyl-
2-chloro-5,10-dimethyl-7,9,10,14b-tetrahydro-6H-isoquinolino[2,1-d][1,4]benzodiazepine
2-Chloro-5,6,7,9,10,14b-hexahydro-5,10-dimethylisoquino[2,1-d][1,4]benzodiazepine
DTXSID30940546
2-Chloro-5,10-dimethyl-5,6,7,9,10,14b-hexahydroisoquinolino[2,1-d][1,4]benzodiazepine