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Nitrofurazone

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Identification
Molecular formula
C6H6Cl2N4O4
CAS number
59-87-0
IUPAC name
2-chloro-N-(2-chloroethyl)-N-[[1-methyl-3-(5-nitro-2-furyl)prop-2-enylidene]amino]ethanamine
State
State

At room temperature, nitrofurazone is typically found as a solid. It is quite stable under normal storage conditions when kept dry and protected from moisture and light. However, it can degrade if exposed to certain environmental conditions over time.

Melting point (Celsius)
236.50
Melting point (Kelvin)
509.65
Boiling point (Celsius)
518.60
Boiling point (Kelvin)
791.75
General information
Molecular weight
198.14g/mol
Molar mass
198.1360g/mol
Density
1.6240g/cm3
Appearence

Nitrofurazone appears as a bright yellow, crystalline powder. This bright coloration is characteristic for many nitroaromatic compounds. It may be slightly hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 2-chloro-N-(2-chloroethyl)-N-[[1-methyl-3-(5-nitro-2-furyl)prop-2-enylidene]amino]ethanamine

The solubility of 2-chloro-N-(2-chloroethyl)-N-[[1-methyl-3-(5-nitro-2-furyl)prop-2-enylidene]amino]ethanamine can be influenced by several factors, primarily due to its complex structure and functional groups. Here are some key points to consider:

  • Polarity: The presence of chlorine atoms and a nitro group suggests that this compound may exhibit polar characteristics, which can enhance its solubility in polar solvents such as water.
  • Hydrogen Bonding: The amine functional group can engage in hydrogen bonding, further improving solubility in polar environments.
  • Chain Length: The ethyl and prop-2-enylidene chains are relatively hydrophobic, which may limit solubility in completely aqueous settings.
  • Solvent Compatibility: This compound is likely to be more soluble in organic solvents like ethanol or acetone compared to non-polar solvents due to its structural features.

In conclusion, the solubility of this compound can be described as a balance between its polar and non-polar characteristics. It's essential to test its solubility in various solvents for practical applications. As the famous chemist Linus Pauling once stated, "The properties of substances are governed by the structures of their molecules." Thus, understanding its molecular structure is key to predicting its solubility behavior.

Interesting facts

Interesting Facts about 2-chloro-N-(2-chloroethyl)-N-[[1-methyl-3-(5-nitro-2-furyl)prop-2-enylidene]amino]ethanamine

This intriguing compound belongs to a class of chemicals that exhibit significant biological activity and can be of interest in both pharmacology and organic chemistry. Here are some noteworthy points:

  • Pharmacological Potential: Compounds similar to this one often display a potential for use in medicinal chemistry, particularly in the development of anticancer drugs. Their structural complexity can lead to various mechanisms of action within biological systems.
  • Chlorine Substituents: The presence of chlorine atoms plays a crucial role in modulating the compound's reactivity and biological efficacy. Chlorinated compounds often have enhanced lipophilicity, which can influence their pharmacokinetic properties.
  • Nitro Group Significance: The 5-nitro-2-furyl group attached to the compound can serve as a bioisostere, which may enhance its pharmacological profiles. This group is frequently found in many drugs that target cancer cells due to its electron-withdrawing nature.
  • Potential Applications: Due to the dual amine structure, this compound could serve not only in medicinal applications but might also inspire the development of ligands in coordination chemistry and catalysts in organic synthesis.
  • Structure-Activity Relationship (SAR): The intricate design of this molecule allows for extensive SAR studies that can lead to derivatives with improved efficacy and reduced side effects, highlighting the importance of each functional group in the overall activity.

As a compound with important implications in the realm of drug development and chemical synthesis, understanding its behavior and interactions in various environments can yield insights that drive future discoveries. As a scientist or a student, delving deeper into the unique properties of such compounds can lead to exciting innovations in therapeutic interventions.