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Chlorphenamine

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Identification
Molecular formula
C17H19Cl2FN2
CAS number
132-22-9
IUPAC name
2-chloro-N-(2-chloroethyl)-N-[(2-fluorophenyl)methyl]ethanamine
State
State

At room temperature, Chlorphenamine is typically in a solid state, appearing as a crystalline powder, but it can also be found in liquid formulations when used in medications.

Melting point (Celsius)
62.00
Melting point (Kelvin)
335.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
274.21g/mol
Molar mass
274.2070g/mol
Density
1.0475g/cm3
Appearence

Chlorphenamine, when pure, is a white or almost white crystalline powder. It is often observed in its commercial formulations as tablets or as a liquid for oral consumption.

Comment on solubility

Solubility Overview

The compound 2-chloro-N-(2-chloroethyl)-N-[(2-fluorophenyl)methyl]ethanamine, known for its intricate structure, exhibits variable solubility behavior due to its functional groups and molecular interactions. Understanding its solubility characteristics is crucial for applications in both medicinal and industrial chemistry.

Solubility Characteristics

Here are some key points regarding the solubility of this compound:

  • Polarity: The presence of chlorine atoms and a fluorinated aromatic ring contributes to the overall polarity of the molecule. This can influence solubility in polar versus non-polar solvents.
  • Solvent Interactions: The compound is likely to have enhanced solubility in:
    • Polar solvents, such as water or alcohols, due to the presence of amine functional groups.
    • Less polar organic solvents, because of the hydrophobic fluorophenyl portion of the molecule.
  • Temperature Dependency: Solubility can vary significantly with temperature; generally, higher temperatures can enhance solubility for many compounds.
  • Concentration Limits: There may be specific concentration thresholds beyond which solubility can decrease due to solute-solute interactions.

Conclusion

In summary, the solubility of 2-chloro-N-(2-chloroethyl)-N-[(2-fluorophenyl)methyl]ethanamine is dictated by its molecular structure, with important implications for its use in various applications. The profound interplay between polarity and solvent choice must always be taken into consideration for optimal usage.

Interesting facts

Interesting Facts about 2-Chloro-N-(2-chloroethyl)-N-[(2-fluorophenyl)methyl]ethanamine

This compound offers a fascinating glimpse into the complex world of organic chemistry, particularly within the realm of amines and their applications in medicinal chemistry. Here are some intriguing points to consider:

  • Pharmaceutical Relevance: The structural features of this compound indicate potential use in developing pharmaceuticals, particularly due to its amine group, which can participate in various biological interactions.
  • Chlorine Substituents: The presence of two chlorine atoms in the structure can significantly influence the compound's reactivity and biological activity. Chlorinated compounds often exhibit unique properties that can be harnessed in drug design.
  • Fluorine Influence: The incorporation of fluorine, especially in an aromatic ring system, can enhance a compound's metabolic stability and overall bioavailability—important factors in drug efficacy.
  • Synthetic Route Exploration: Chemists might be interested in the methods for synthesizing this compound. The synthetic pathways could involve intricate reactions, including nucleophilic substitutions and coupling reactions, showcasing the creativity of synthetic organic chemistry.
  • Research Potential: Given its unique structure, this compound might be a subject for further study, impacting areas from pharmacology to material science, potentially leading to the discovery of new therapies.

As scientists continue to explore compounds like this, they pave the way for innovations in health and technology, underlining the significance of understanding molecular behavior and interactions.

Synonyms
N,N-Bis(2-chloroethyl)-o-fluorobenzylamine
o-Fluoro-dcba
BRN 2645648
o-Fluoro-di-(2-chloroethyl)-benzylamine
N,N-Bis(2-chloroethyl)-2-fluorobenzenemethanamine
Benzenemethanamine, N,N-bis(2-chloroethyl)-2-fluoro-
BENZYLAMINE, N,N-BIS(2-CHLOROETHYL)-o-FLUORO-
DTXSID30165555
DTXCID0088046
Benzenemethanamine, N,N-bis(2-chloroethyl)-2-fluoro-(9CI)
1542-45-6
2-chloro-N-(2-chloroethyl)-N-[(2-fluorophenyl)methyl]ethanamine
Benzenemethanamine, N,N-bis(2-chloroethyl)-2-fluoro- (9CI)
benzylamine, N,N-bis(2-chloroethyl)-2-fluoro-