Skip to main content

Clomipramine

ADVERTISEMENT
Identification
Molecular formula
C19H23Cl2N
CAS number
303-49-1
IUPAC name
2-chloro-N-(2-chloroethyl)-N-[(3-chloro-4-methoxy-phenyl)methyl]ethanamine
State
State

At room temperature, Clomipramine is a solid. It is typically kept in tightly closed containers to avoid moisture absorption due to its crystalline nature.

Melting point (Celsius)
189.50
Melting point (Kelvin)
462.65
Boiling point (Celsius)
540.80
Boiling point (Kelvin)
813.95
General information
Molecular weight
314.25g/mol
Molar mass
314.2470g/mol
Density
1.1900g/cm3
Appearence

Clomipramine appears as a white to cream-colored, crystalline powder. It is sparingly soluble in water but more soluble in alcohol and chloroform, exhibiting a pearlescent look when in crystal form.

Comment on solubility

Solubility of 2-chloro-N-(2-chloroethyl)-N-[(3-chloro-4-methoxy-phenyl)methyl]ethanamine

The solubility of 2-chloro-N-(2-chloroethyl)-N-[(3-chloro-4-methoxy-phenyl)methyl]ethanamine can be quite interesting to consider due to its complex chemical structure. This compound consists of several functional groups that influence its solubility characteristics in different solvents.

Key Factors Affecting Solubility:

  • Polarity: The presence of electronegative chlorine atoms and a methoxy group can enhance the polar nature of the molecule, contributing to solubility in polar solvents like water.
  • Hydrophobic Regions: The phenyl ring adds a hydrophobic character, which may limit its solubility in highly polar solvents, thus making it more soluble in organic solvents like ethanol or dichloromethane.
  • Temperature: Increasing temperature generally enhances solubility, so evaluating this compound's behavior at different temperatures could provide further insights.

In general, while certain components of this compound suggest it could be soluble in water, practical solubility may vary due to the balancing effects of hydrophobic and hydrophilic characteristics. Therefore, experimentation is necessary to precisely determine the solubility range for specific conditions.


In conclusion, understanding the solubility profile of 2-chloro-N-(2-chloroethyl)-N-[(3-chloro-4-methoxy-phenyl)methyl]ethanamine entails a detailed analysis of its molecular structure and interactions with various solvents.

Interesting facts

Interesting Facts about 2-chloro-N-(2-chloroethyl)-N-[(3-chloro-4-methoxy-phenyl)methyl]ethanamine

The compound 2-chloro-N-(2-chloroethyl)-N-[(3-chloro-4-methoxy-phenyl)methyl]ethanamine is a fascinating example of a complex organic compound that showcases the intricate world of amino compounds. Here are some interesting insights into this compound:

  • Synthetic Applications: This compound belongs to a class of chemicals often utilized in the synthesis of pharmaceuticals. The unique arrangement of chlorines and methoxy groups allows it to participate in various chemical reactions, potentially leading to novel drug development.
  • Biological Activity: Many compounds with a similar structure have been studied for their potential therapeutic effects. They may exhibit properties such as anti-inflammatory, analgesic, or even antimicrobial activities, making them valuable in medicinal research.
  • Structure-Activity Relationship (SAR): This compound’s design exemplifies the importance of understanding how modifications in chemical structure affect biological activity. Scientists often modify groups to enhance efficacy or reduce toxicity, as seen in the presence of chloro and methoxy groups.
  • Environmental Impact: Like many chlorinated compounds, this chemical's persistence in the environment and potential for bioaccumulation raises concerns about its ecological impact. Researchers continue to explore its fate in biological systems.

Overall, compounds like 2-chloro-N-(2-chloroethyl)-N-[(3-chloro-4-methoxy-phenyl)methyl]ethanamine are not just intriguing due to their structures—they represent the cutting edge of research in organic chemistry and pharmaceutical sciences. As the field progresses, understanding such compounds could lead to breakthroughs in healthcare and environmental science.

Synonyms
64236-10-8
Benzenemethanamine, 3-chloro-N,N-bis(2-chloroethyl)-4-methoxy-
2-chloro-N-(2-chloroethyl)-N-[(3-chloro-4-methoxyphenyl)methyl]ethanamine
N,N-bis(2-chloroethyl)-N-(3-chloro-4-methoxybenzyl)amine
CHEMBL1620685
DTXSID90214437
3-Chloro-N,N-bis(2-chloroethyl)-4-methoxybenzenemethanamine
AKOS000505098
NCGC00245110-01
ST50227798
AE-848/31943002
bis(2-chloroethyl)[(3-chloro-4-methoxyphenyl)methyl]amine