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Chlorambucil

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Identification
Molecular formula
C14H19Cl2FN2O2
CAS number
305-03-3
IUPAC name
2-chloro-N-(2-chloroethyl)-N-[(3-fluorophenyl)methyl]ethanamine
State
State

At room temperature, Chlorambucil is in a solid state in the form of a crystalline powder.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
355.00
Boiling point (Kelvin)
628.15
General information
Molecular weight
304.20g/mol
Molar mass
304.1970g/mol
Density
1.2610g/cm3
Appearence

Chlorambucil typically appears as a pale yellow crystalline powder. It is odorless, and the color can vary slightly based on purity and conditions.

Comment on solubility

Solubility of 2-chloro-N-(2-chloroethyl)-N-[(3-fluorophenyl)methyl]ethanamine

The solubility of 2-chloro-N-(2-chloroethyl)-N-[(3-fluorophenyl)methyl]ethanamine in various solvents is influenced by its unique chemical structure. Understanding its solubility can provide insights into its potential applications and behavior in different environments.

Factors Affecting Solubility:

  • Polarity: The compound contains polar functional groups due to the presence of chlorine and amino groups, which can increase its solubility in polar solvents.
  • Hydrogen Bonding: The amine group may engage in hydrogen bonding, enhancing solubility in protic solvents like water and alcohols.
  • Size and Weight: The molecular weight and size can inhibit solubility in less polar solvents, as larger molecules tend to have lower solubility.

Typically, the solubility of such compounds is assessed using different solvent systems. Some important observations include:

  • High Solubility: Expected in polar solvents such as water, methanol, or ethanol.
  • Limited Solubility: Predicted in non-polar solvents like hexane or toluene due to its more polar nature.

In conclusion, the solubility characteristics of 2-chloro-N-(2-chloroethyl)-N-[(3-fluorophenyl)methyl]ethanamine make it an interesting compound for further study. Its solubility profile can be critical for understanding its behavior in biological systems and potential usage in various chemical applications.

Interesting facts

Interesting Facts about 2-chloro-N-(2-chloroethyl)-N-[(3-fluorophenyl)methyl]ethanamine

2-chloro-N-(2-chloroethyl)-N-[(3-fluorophenyl)methyl]ethanamine, often abbreviated as a complex organic compound, is a fascinating example in the field of medicinal chemistry. Here are some key points to consider:

  • Pharmaceutical Potential: This compound belongs to a class of amines that is often explored in drug design, particularly in developing medications that target the central nervous system.
  • Substitution Effects: The presence of chloro and fluorine atoms can significantly influence the compound's reactivity and interactions with biological targets. These halogens can enhance lipophilicity, which may aid in crossing cell membranes.
  • Structure-Activity Relationship: Scientists focus on the structure-activity relationship (SAR) of compounds like this one to understand how variations in chemical structure alter biological activity. The modifications in the amine and aromatic moiety could provide insights into optimizing therapeutic effects.
  • Research Applications: This compound could be utilized in various research applications, including studying receptor binding, understanding metabolic pathways, and exploring new drug formulations.

As noted by researchers, "The exploration of synthetic amines continues to pave the way for advancements in pharmacology and medicinal chemistry, enabling the development of better therapeutic agents."

Overall, 2-chloro-N-(2-chloroethyl)-N-[(3-fluorophenyl)methyl]ethanamine serves as a noteworthy example of how complex organic compounds can provide insights into field advancements and potential therapeutic applications.

Synonyms
m-Fluoro-dcba
N,N-Bis(2-chloroethyl)-m-fluorobenzylamine
m-Fluoro-di-(2-chloroethyl)-benzylamine
BRN 2647552
N,N-Bis(2-chloroethyl)-3-fluorobenzenemethanamine
Benzenemethanamine, N,N-bis(2-chloroethyl)-3-fluoro-
BENZYLAMINE, N,N-BIS(2-CHLOROETHYL)-m-FLUORO-
DTXSID70165554
DTXCID5088045
Benzenemethanamine, N,N-bis(2-chloroethyl)-3-fluoro-(9CI)
1542-44-5
2-chloro-N-(2-chloroethyl)-N-[(3-fluorophenyl)methyl]ethanamine
Benzenemethanamine, N,N-bis(2-chloroethyl)-3-fluoro- (9CI)
NCIOpen2_008838
AKOS040753047
benzylamine, N,N-bis(2-chloroethyl)-3-fluoro-