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Chlorambucil

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Identification
Molecular formula
C14H19Cl3NO2
CAS number
305-03-3
IUPAC name
2-chloro-N-(2-chloroethyl)-N-[(5-chloro-2-methoxy-phenyl)methyl]ethanamine
State
State

At room temperature, Chlorambucil is a solid. It is used in the form of tablets for therapeutic applications.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
355.30
Boiling point (Kelvin)
628.45
General information
Molecular weight
304.69g/mol
Molar mass
304.6860g/mol
Density
1.3000g/cm3
Appearence

Chlorambucil is typically a pale yellow, crystalline powder. It is poorly soluble in water and possesses a slightly aromatic odor due to its chemical structure.

Comment on solubility

Solubility of 2-chloro-N-(2-chloroethyl)-N-[(5-chloro-2-methoxy-phenyl)methyl]ethanamine

The solubility of 2-chloro-N-(2-chloroethyl)-N-[(5-chloro-2-methoxy-phenyl)methyl]ethanamine can be influenced by several factors due to its complex chemical structure. Here are some key points regarding its solubility:

  • Solvent Interactions: This compound may exhibit varying solubility in polar vs. nonpolar solvents, often dissolving better in organic solvents due to its hydrophobic aromatic substituents.
  • Temperature Dependency: Solubility can increase with temperature; thus, higher temperatures may enhance the dissolution of this compound in suitable solvents.
  • pH Sensitivity: The solubility can also be influenced by the pH of the solution, given the presence of amine functional groups which may become protonated under acidic conditions.
  • Structure-Activity Relationship: The presence of multiple chlorine and methoxy groups may contribute to unique solubility characteristics compared to similar compounds.

In conclusion, the solubility of this compound, while potentially limited in water, could be enhanced in various organic solvents, and understanding these characteristics can greatly facilitate its practical applications in different environments.

Interesting facts

Interesting Facts about 2-Chloro-N-(2-chloroethyl)-N-[(5-chloro-2-methoxy-phenyl)methyl]ethanamine

This complex organic compound is a notable member of the amine family, showcasing the intriguing interplay of chlorine and methoxy groups. Scientists have been particularly interested in this compound due to its potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeted at various health conditions.

Key Features

  • Multi-functional Structure: The presence of multiple chlorine atoms and a methoxy group indicates significant chemical reactivity, which can lead to various derivatives and modifications to enhance biological activity.
  • Potential Biological Significance: Compounds containing chlorinated aromatic systems often exhibit unique biological properties that can be exploited in drug design. This compound's structure suggests it may interact with biological targets in intriguing ways.
  • Industrial Relevance: Chlorinated compounds play vital roles in chemical industries, notably in the manufacture of agrochemicals and pharmaceuticals, making this compound of interest for researchers looking to synthesize safer and more effective products.

Researchers often examine the structure-activity relationship (SAR) of such compounds to understand how variations in chemical structure can affect biological activity and efficacy. As the field advances, the study of compounds like this one could lead to significant breakthroughs in designing targeted therapies to fight diseases.

In laboratory settings, the synthesis of this compound can also provide an excellent opportunity for students to explore various synthetic pathways and techniques, such as nucleophilic substitutions and reductive amination.

Overall, 2-chloro-N-(2-chloroethyl)-N-[(5-chloro-2-methoxy-phenyl)methyl]ethanamine is not just another compound in the catalog of chemicals; it exemplifies the beauty and complexity found in organic chemistry, with potential implications in multiple scientific fields.

Synonyms
Benzenemethanamine, 5-chloro-N,N-bis(2-chloroethyl)-2-methoxy-
64236-09-5
5-Chloro-N,N-bis(2-chloroethyl)-2-methoxybenzenemethanamine
DTXSID30214436