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Nitrogen Mustard HN1

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Identification
Molecular formula
C6H13Cl2N
CAS number
538-07-8
IUPAC name
2-chloro-N-(2-chloroethyl)-N-ethyl-ethanamine
State
State

Nitrogen Mustard HN1 is typically found as a liquid at room temperature. It is part of a group of cytotoxic compounds known as nitrogen mustards, which are used for their alkylating properties in chemotherapy and as chemical warfare agents.

Melting point (Celsius)
-39.00
Melting point (Kelvin)
234.15
Boiling point (Celsius)
182.00
Boiling point (Kelvin)
455.15
General information
Molecular weight
156.08g/mol
Molar mass
156.0580g/mol
Density
1.0700g/cm3
Appearence

Nitrogen Mustard HN1 is a colorless liquid. It may appear as a yellowish liquid depending on impurities and exposure to light.

Comment on solubility

Solubility of 2-chloro-N-(2-chloroethyl)-N-ethyl-ethanamine

The solubility of 2-chloro-N-(2-chloroethyl)-N-ethyl-ethanamine, a compound with a rather complex structure, is influenced by several factors, including its molecular interactions and the presence of functional groups.

This compound tends to be:

  • Moderately soluble in polar solvents, such as water, due to the presence of amine functional groups.
  • More soluble in organic solvents like ethanol or dimethyl sulfoxide (DMSO), thanks to its hydrophobic ethyl and chloroalkyl moieties.
  • Less soluble in non-polar solvents, which struggle to interact effectively with the polar sections of the molecule.

In general, the solubility of such amine compounds can often be summarized by the phrase, "like dissolves like". This means:

  • Polar compounds are soluble in polar solvents, while
  • Non-polar compounds are soluble in non-polar solvents.

Therefore, the unique structure of 2-chloro-N-(2-chloroethyl)-N-ethyl-ethanamine results in a solubility profile that is tailored to specific solvent environments, making it both intriguing and useful in various applications.

Interesting facts

Exploring 2-Chloro-N-(2-chloroethyl)-N-ethyl-ethanamine

2-Chloro-N-(2-chloroethyl)-N-ethyl-ethanamine is a fascinating compound with a diverse range of applications in the fields of chemistry and medicine. Here are some intriguing facts about this compound:

  • Pharmaceutical Potential: This compound belongs to a class of compounds known for their potential use in pharmaceuticals, particularly in the synthesis of various therapeutics. Compounds with similar structures are often explored for their properties as anti-cancer agents.
  • Quaternary Ammonium Compounds: As part of its molecular structure, this compound showcases characteristics typical of quaternary ammonium salts, which can interact effectively with biological membranes, influencing their permeability and fluidity.
  • Reactive Intermediate: Due to the presence of chloro groups, 2-chloro-N-(2-chloroethyl)-N-ethyl-ethanamine can undergo nucleophilic substitutions, making it a versatile intermediate in organic synthesis.
  • Safety Considerations: Working with this compound requires careful handling due to its reactivity and potential toxicity. Proper laboratory safety procedures are essential to minimize exposure during synthesis and application.
  • Structure-Activity Relationship (SAR): Understanding the impact of structural modifications on biological activity is crucial in medicinal chemistry. The molecular structure of this compound provides ample opportunity for examining SAR in drug design.

Overall, 2-chloro-N-(2-chloroethyl)-N-ethyl-ethanamine serves as a vital example in the ongoing exploration of chemical compounds that hold promise for future therapeutic developments. Its unique structure and reactivity may lead to groundbreaking discoveries in drug formulation and bioactivity.

In summary, as scientists continue to delve into the properties of chemical compounds, 2-chloro-N-(2-chloroethyl)-N-ethyl-ethanamine shines as a noteworthy candidate with potential advancements in various fields, from medicinal chemistry to organic synthesis.

Synonyms
Bis(2-chloroethyl)ethylamine
538-07-8
ETHYLBIS(2-CHLOROETHYL)AMINE
Nitrogen mustard (HN-1)
HSDB 6392
UNII-B75ZZA7WIG
Ethanamine, 2-chloro-N-(2-chloroethyl)-N-ethyl-
UN 2810
BRN 1735676
Ethyl-bis(2-chloroethyl)amine
DTXSID0060220
3-04-00-00241 (Beilstein Handbook Reference)
NITROGEN MUSTARD (HN-1) [HSDB]
EthylS
2,2'Dichlorotriethylamine
: NITROGEN MUSTARD
Bis(2chloroethyl)ethylamine
Ethylbis(2chloroethyl)amine
2,2'-Dichloro-triethylamine
n-ethylbis(2-chloroethyl)amine
DTXCID1041504
2ChloroN(2chloroethyl)Nethylethanamine
2-Chloro-N-(2-chloroethyl)-N-ethyl-ethanamine
uqzpghojmqtohb-uhfffaoysa-n
Ethyl-S
2-Chloro-N-(2-chloroethyl)-N-ethylethanamine
2,2'-Dichlorotriethylamine
Triethylamine, 2,2'-dichloro-
TL 329
TL 1149
B75ZZA7WIG
HN1
HN-1 cpd
Ethylbis(beta-chloroethyl)amine
AI3-16200
SCHEMBL377126
N-ethyl-bis(2-chloroethyl)amine
ethane, bis(2-chloroethyl)amino-
Ethylbis(.beta.-chloroethyl)amine
ethyl-bis-(2-chloro-ethyl)-amine
AKOS006278185
N,N-Bis(2-chloroethyl)-N-ethylamine #
NS00094970
Q5635296