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Chlorambucil

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Identification
Molecular formula
C14H19Cl2NO2
CAS number
305-03-3
IUPAC name
2-chloro-N-[2-(diethylamino)ethyl]-2-(2,3,4,5-tetrachlorocyclopenta-2,4-dien-1-ylidene)acetamide
State
State

At room temperature, chlorambucil is typically found as a solid.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
363.00
Boiling point (Kelvin)
636.15
General information
Molecular weight
304.21g/mol
Molar mass
304.6490g/mol
Density
1.2216g/cm3
Appearence

Chlorambucil appears as a pale yellow crystalline powder. It is relatively stable under normal conditions but begins to discolor on exposure to light. It is slightly soluble in water and freely soluble in methanol and chloroform.

Comment on solubility

Solubility of 2-chloro-N-[2-(diethylamino)ethyl]-2-(2,3,4,5-tetrachlorocyclopenta-2,4-dien-1-ylidene)acetamide

The solubility of 2-chloro-N-[2-(diethylamino)ethyl]-2-(2,3,4,5-tetrachlorocyclopenta-2,4-dien-1-ylidene)acetamide in various solvents can be quite interesting due to its complex molecular structure. Several key points regarding its solubility include:

  • Polar Solvents: This compound may exhibit a degree of solubility in polar organic solvents due to the presence of the diethylamino group, which can interact favorably with polar solvents.
  • Apolar Solvents: On the other hand, due to the presence of the highly chlorinated cyclopentadiene moiety, its solubility in nonpolar solvents may be significant as well.
  • pH Dependence: The solubility can vary with pH, considering the amide functional group, which may affect ionization and, consequently, solubility in aqueous solutions.
  • Temperature Effects: The solubility typically increases with temperature; hence, heating may enhance the dissolution rate in various solvent systems.

In summary, understanding the solubility of this compound is crucial, especially in applications where solvent choice plays a significant role. Engaging with various solvents and conditions may lead to detecting optimal solubility characteristics that enhance its practical usability. Remember, "A solute's compatibility with a solvent matters fundamentally in its chemical applications!"

Interesting facts

Interesting Facts about 2-chloro-N-[2-(diethylamino)ethyl]-2-(2,3,4,5-tetrachlorocyclopenta-2,4-dien-1-ylidene)acetamide

This compound, commonly referred to in scientific literature, is a fascinating example of organic chemistry with a variety of potential applications. Here are some intriguing facts:

  • Complex Structure: The compound features a unique structural configuration, which includes multiple functional groups. This complexity may lead to interesting pharmacological properties.
  • Chlorination: The presence of multiple chlorine atoms in its structure can significantly impact reactivity and stability, potentially making it useful in various chemical syntheses.
  • Biological Activity: Compounds with similar structures are often studied for their antitumor and antimicrobial activities. This compound may also hold promise in medicinal chemistry.
  • Applications in Dye Chemistry: Due to the conjugated double bonds in its cyclopentadiene ring, it may be useful in dye manufacturing or as a pigment, showcasing vibrant colors.
  • Research Potential: The molecules containing diethylamino groups are often explored for their roles in drug design, particularly in improving solubility and bioavailability of compounds.

As a budding chemist, understanding such compounds is critical as they often serve as building blocks or lead compounds for novel therapies. The interplay between chlorination and amino functionality opens avenues for modifying biological activity, illustrating the dynamic nature of chemical research.

"The beauty of chemistry lies in its complexity and the endless possibilities it offers for innovation."

Synonyms
6284-49-7
MLS002638006
Acetamide, N-(2-diethylaminoethyl)-2-chloro-2-(tetrachloro-2,4-cyclopentadien-1-ylidene)-
WLN: L5YJ AUYGVM2N2&2 BG CG DG EG
NSC-7419
N-(2-Diethylaminoethyl)-2-chloro-2-(tetrachloro-2,4-cyclopentadien-1-ylidene)acetamide
5Y988K56L8
SMR001547510
NSC 7419
NSC7419
cid_22694
CHEMBL1733469
UNII-5Y988K56L8
BDBM97024
DTXSID30212013
HMS3085E12
Acetamide,4-cyclopentadien-1-ylidene)-
2-chloro-N-[2-(diethylamino)ethyl]-2-(2,3,4,5-tetrachlorocyclopenta-2,4-dien-1-ylidene)acetamide
Acetamide, 2-chloro-N-(2-(diethylamino)ethyl)-2-(2,3,4,5-tetrachloro-2,5-cyclopentadien-1-ylidene)-
Acetamide,3,4,5-tetrachloro-2,5-cyclopentadien-1-ylidene)-
N-[2-(Diethylamino)ethyl]-2-chloro-2-(tetrachloro-2,4-cyclopentadien-1-ylidene)acetamide
2-chloranyl-N-[2-(diethylamino)ethyl]-2-[2,3,4,5-tetrakis(chloranyl)cyclopenta-2,4-dien-1-ylidene]ethanamide
2-CHLORO-N-(2-(DIETHYLAMINO)ETHYL)-2-(2,3,4,5-TETRACHLORO-2,4-CYCLOPENTADIEN-1-YLIDENE)ACETAMIDE
2-chloro-N-[2-(diethylamino)ethyl]-2-(2,3,4,5-tetrachloro-1-cyclopenta-2,4-dienylidene)acetamide
ACETAMIDE, 2-CHLORO-N-(2-(DIETHYLAMINO)ETHYL)-2-(2,3,4,5-TETRACHLORO-2,4-CYCLOPENTADIEN-1-YLIDENE)-