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2-Chloro-N-(2,5-dimethoxyphenyl)acetamide

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Identification
Molecular formula
C10H12ClNO3
CAS number
66441-23-4
IUPAC name
2-chloro-N-(2,5-dimethoxyphenyl)acetamide
State
State

At room temperature, 2-chloro-N-(2,5-dimethoxyphenyl)acetamide is in a solid state.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
356.00
Boiling point (Kelvin)
629.15
General information
Molecular weight
229.67g/mol
Molar mass
229.6670g/mol
Density
1.2860g/cm3
Appearence

2-Chloro-N-(2,5-dimethoxyphenyl)acetamide is a solid compound. It typically appears as a white to off-white crystalline substance.

Comment on solubility

Solubility of 2-chloro-N-(2,5-dimethoxyphenyl)acetamide

The solubility of 2-chloro-N-(2,5-dimethoxyphenyl)acetamide in various solvents can provide insight into its chemical behavior and potential applications. Here are some key points regarding its solubility:

  • Polar Solvents: This compound may exhibit some degree of solubility in polar solvents such as water and alcohols. The presence of the amide functional group (-CONH2) typically enhances solubility in polar environments.

  • Non-Polar Solvents: It is likely to have a lower solubility in non-polar solvents, similar to many aromatic compounds, due to the presence of the bulky methoxy groups which can hinder interactions with non-polar solvents.

  • Temperature Effects: As is common with many organic compounds, solubility may increase with temperature, leading to higher dissolution rates in heated solvents.

  • pH Dependence: The solubility may also be influenced by pH levels, especially considering the amide group, which could potentially ionize under certain conditions, altering its solubility characteristics.

In summary, the solubility of 2-chloro-N-(2,5-dimethoxyphenyl)acetamide is likely to be influenced by a combination of its functional groups and the nature of the solvent. As always, empirical testing is the best method to ascertain its precise solubility profile.

Interesting facts

Interesting Facts About 2-chloro-N-(2,5-dimethoxyphenyl)acetamide

2-chloro-N-(2,5-dimethoxyphenyl)acetamide is a fascinating compound that has garnered interest in both the pharmaceutical and chemical research communities. Here are some engaging insights about this compound:

  • Structure and Functionality: This compound features a unique combination of a chloro group and methoxy substituents on the aromatic ring, which can influence its biological activity. Such substitutions often enhance the compound's ability to interact with various enzymes or receptors in the body.
  • Pharmaceutical Relevance: Compounds like 2-chloro-N-(2,5-dimethoxyphenyl)acetamide are investigated for their potential therapeutic effects. The presence of the dimethoxyphenyl group has been linked to various biological activities, thus making it a useful scaffold for drug development.
  • Research Applications: In medicinal chemistry, compounds with chloro and methoxy modifications are often explored as leads for new drugs. They serve as starting points for structure-activity relationship studies to optimize efficacy and reduce side effects.
  • Synthetic Pathways: The synthesis of this compound often involves strategic steps to ensure the correct arrangement of functional groups. It exemplifies how organic chemists can manipulate molecular structure to create compounds with desired properties.
  • Scientific Exploration: Researchers are continuously looking into various derivatives of acetamide compounds. Their investigations may uncover new applications in treating diseases or in other industrial uses.

The intricate design and potential applications of 2-chloro-N-(2,5-dimethoxyphenyl)acetamide illustrate the beauty of chemical science, where every subtle change can lead to significant differences in behavior and effect.

Synonyms
2-Chloro-N-(2,5-dimethoxyphenyl)acetamide
2-Chloro-2',5'-dimethoxyacetanilide
ACETANILIDE, 2-CHLORO-2',5'-DIMETHOXY-
HJJ4RA4W6U
NSC 213640
BRN 2374864
NSC-213640
NSC-216012
DTXSID50176688
4-13-00-02550 (Beilstein Handbook Reference)
Acetamide, N-(2,5-dimethoxyphenyl)-2-chloro-
RefChem:86139
DTXCID3099179
661-139-6
BDDQUHPZDJEQRL-UHFFFAOYSA-N
22158-78-7
2',5'-Dimethoxy-2-chloroacetanilide
MFCD00095383
Acetamide, 2-chloro-N-(2,5-dimethoxyphenyl)-
2-Chloro-N-(2,5-dimethoxy-phenyl)-acetamide
Acetanilide,5'-dimethoxy-
Acetamide,5-dimethoxyphenyl)-
WLN: G1VMR BO1 EO1
N-(2,5-dimethoxyphenyl)-2-chloroacetamide
NSC216012
UNII-HJJ4RA4W6U
SCHEMBL3757797
ALBB-002275
BBL015231
NSC213640
SBB004520
STK415084
AKOS000268695
JS-3029
NCGC00661336-01
ST082747
SY081547
2-chloro-N-(2,5-dimethoxy-phenyl)acetamide
CS-0116872
EN300-01587
H22010
Z87002084
F2190-0202