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Acetanilide

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Identification
Molecular formula
C9H10ClNO2
CAS number
1191-49-9
IUPAC name
2-chloro-N-(3-methoxyphenyl)acetamide
State
State

At room temperature, 2-chloro-N-(3-methoxyphenyl)acetamide is in a solid-state, typically as a powder or crystalline solid. It needs to be stored in a sealed container in a cool, dry place to prevent any degradation or reaction with atmospheric moisture.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
333.80
Boiling point (Kelvin)
606.95
General information
Molecular weight
199.65g/mol
Molar mass
199.6450g/mol
Density
1.2280g/cm3
Appearence

2-Chloro-N-(3-methoxyphenyl)acetamide typically appears as a white to off-white crystalline powder. This compound may be either completely opaque or may exhibit some translucency depending on the crystal size and packing. It is not notably hygroscopic and stable at room temperature when protected from moisture and light.

Comment on solubility

Solubility of 2-chloro-N-(3-methoxyphenyl)acetamide

The solubility of 2-chloro-N-(3-methoxyphenyl)acetamide, a compound featuring both polar and non-polar characteristics, is influenced by several factors that dictate its behavior in various solvents. Understanding these factors is essential for its application in chemical processes. Here are some important considerations regarding its solubility:

  • Polar vs. Non-Polar Solvents: This compound is likely to be more soluble in polar solvents such as water due to the presence of the amide functional group, which can form hydrogen bonds.
  • Temperature Dependency: As with many organic compounds, an increase in temperature may enhance its solubility, making it more effective for reactions that occur at elevated temperatures.
  • pH Influence: The solubility can also be affected by the pH of the solvent. Being an amide, it may undergo protonation or deprotonation in varying pH conditions, which could alter its solubility.
  • Crystal Structure: The crystalline structure of 2-chloro-N-(3-methoxyphenyl)acetamide may play a significant role in its overall solubility. Different polymorphs can exhibit varying solubility behaviors.

In summary, while 2-chloro-N-(3-methoxyphenyl)acetamide shows favorable solubility characteristics due to its polar amide group, its solubility can vary significantly based on the solvent, temperature, pH, and molecular structure. This multifaceted nature makes understanding its solubility a key aspect of utilizing this compound effectively in scientific applications.

Interesting facts

Interesting Facts about 2-chloro-N-(3-methoxyphenyl)acetamide

2-chloro-N-(3-methoxyphenyl)acetamide is an intriguing compound that belongs to the class of amides, which are organic compounds derived from carboxylic acids. Here are some noteworthy aspects of this compound:

  • Pharmacological Relevance: This compound is of particular interest in medicinal chemistry due to its potential biological activities. It may serve as a template for developing new pharmaceuticals.
  • Structure Activity Relationship (SAR): The structural features of 2-chloro-N-(3-methoxyphenyl)acetamide make it a subject of SAR studies, which help in understanding how modifications can influence its biological activity.
  • Role of the Chlorine Atom: The presence of the chlorine substituent is crucial as it can enhance the lipophilicity of the compound, potentially improving its ability to permeate cell membranes.
  • Methoxy Group Significance: The methoxy group (–OCH3) attached to the aromatic ring contributes to electron-donating properties, which may affect the reactivity and interaction of the molecule with biological targets.
  • Applications in Research: Researchers may explore this compound in various studies, including drug design, synthesis of new materials, and exploring its interaction with specific enzymes.

In summary, 2-chloro-N-(3-methoxyphenyl)acetamide serves as a valuable compound within the realm of chemical research, holding promise for advancements in pharmaceuticals and a deeper understanding of its chemical behavior. As scientists continue to investigate its properties, we may uncover even more fascinating details about this compound!

Synonyms
2-chloro-N-(3-methoxyphenyl)acetamide
633-073-8
17641-08-6
Acetamide, 2-chloro-N-(3-methoxyphenyl)-
2-Chloro-N-(3-methoxy-phenyl)-acetamide
MFCD00018900
Acetamide, 2-chloro-N-(3-methoxyphenyl)- (9CI)
2-Chloro-m-acetanisidide
N-(3-Anisyl)chloroacetamide
N-(Chloroacetyl)-m-anisidide
BRN 1104501
Acetamide,2-chloro-N-(3-methoxyphenyl)-
m-ACETANISIDIDE, 2-CHLORO-
Aripiprazole Impurity N19
F1791-1517
orb1986660
SCHEMBL1837650
SCHEMBL31390722
DTXSID30170129
JJNAIBJFYFWTIA-UHFFFAOYSA-N
ALBB-002272
SBB000391
STK414995
AKOS000265799
2-chloro-N-(3-methoxyphenyl)-acetamide
NCGC00661469-01
AS-64579
ST012341
SY081767
CS-0074143
EN300-01584
W18701
Z56896296