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Chlorhexidine

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Identification
Molecular formula
C10H10Cl2N2O2
CAS number
3697-42-5
IUPAC name
2-chloro-N-[4-[(2-chloroacetyl)amino]phenyl]acetamide
State
State

At room temperature, the compound is in a solid state. It is stable under normal conditions and does not readily undergo phase transitions at room ambiance.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
282.13g/mol
Molar mass
282.1340g/mol
Density
1.4400g/cm3
Appearence

The compound appears as a white to off-white crystalline powder. It is typically used in a solid form and may appear slightly different based on its level of hydration or form of presentation (e.g., powder, crystalline blocks, etc.).

Comment on solubility

Solubility of 2-chloro-N-[4-[(2-chloroacetyl)amino]phenyl]acetamide

2-chloro-N-[4-[(2-chloroacetyl)amino]phenyl]acetamide, a compound with a complex structure, exhibits notable solubility characteristics that are largely influenced by its functional groups and polarity. Understanding its solubility can provide insight into its potential applications and behavior in various environments.

Key solubility points to consider include:

  • Polarity: The presence of multiple electronegative chlorine atoms and amide functional groups tends to increase the polarity of the molecule, enhancing its solubility in polar solvents such as water.
  • Hydrogen bonding: The amide functional groups can participate in hydrogen bonding with water, which can significantly boost solubility.
  • Solvent interactions: This compound may show differing solubility in various solvents. For instance, it may be more soluble in organic solvents due to the presence of aromatic rings, which can stabilize interactions with non-polar phases.

In summary, while the compound 2-chloro-N-[4-[(2-chloroacetyl)amino]phenyl]acetamide demonstrates notable solubility in polar solvents due to hydrogen bonding and its polar nature, its solubility profile can greatly change depending on the chosen solvent and environmental conditions. This brief overview provides a glimpse into the complexity of its solubility, highlighting the factors that influence its behavior in solution.

Interesting facts

Interesting Facts About 2-chloro-N-[4-[(2-chloroacetyl)amino]phenyl]acetamide

The compound 2-chloro-N-[4-[(2-chloroacetyl)amino]phenyl]acetamide is a fascinating member of the class of compounds known as acetamides. Here are some illuminating facts about this intriguing chemical:

  • Pharmaceutical Relevance: This compound has garnered attention for its potential use in medicinal chemistry. Compounds of this type are often investigated for their biological properties and may serve as precursors in the synthesis of pharmaceuticals.
  • Mechanism of Action: As a derivative of acetylated amine and chlorinated aromatic systems, it may exhibit significant interactions with biological targets, competing with other biomolecules, thus influencing various physiological processes.
  • Toxicological Studies: Understanding the safety profiles and toxicological implications of such compounds is crucial. Many research studies are focused on evaluating both the therapeutic potential and potential side effects of compounds like this one.
  • Structure-Activity Relationship (SAR): The unique structure of 2-chloro-N-[4-[(2-chloroacetyl)amino]phenyl]acetamide allows chemists to explore SAR, which is fundamental for designing more potent and selective compounds in drug discovery.
  • Historical Importance: The development of chlorinated acetamides has historical significance in the synthesis of various agrochemicals and pharmaceuticals, leading to a better understanding of chemical reactivity and process optimization.

In summary, 2-chloro-N-[4-[(2-chloroacetyl)amino]phenyl]acetamide not only plays a pivotal role in chemical research but also highlights the continuous journey of chemists in unraveling the complexities of molecular interactions in biological systems.

Synonyms
2653-08-9
N,N'-Bis(chloroacetyl)-p-phenylenediamine
N,N'-1,4-Phenylenebis(2-chloroacetamide)
N,N'-(1,4-Phenylene)bis(2-chloroacetamide)
NSC 49396
2-chloro-N-[4-[(2-chloroacetyl)amino]phenyl]acetamide
2-Chloro-N-[4-(2-chloro-acetylamino)-phenyl]-acetamide
2-chloro-N-[4-(2-chloroacetamido)phenyl]acetamide
ACETAMIDE, N,N'-(p-PHENYLENE)BIS(2-CHLORO-
NSC-15947
NSC-49396
Acetamide, N,N'-1,4-phenylenebis(2-chloro-
Acetamide, N,N'-1,4-phenylenebis[2-chloro-
Acetamide,N'-(p-phenylene)bis[2-chloro-
p-Phenylenediamine,N'-bis[chloroacetyl]-
Acetamide,N'-1,4-phenylenebis[2-chloro-
NSC 15947
2-CHLORO-N-(4-(2-CHLORO-ACETYLAMINO)-PHENYL)-ACETAMIDE
1,4-bis(2-chloro-acetylamino)-benzene
BRN 2740101
p-Phenylenediamine, N,N'-bis(chloroacetyl)-
NC93QF9BNN
SCHEMBL9081388
DTXSID60181102
ALBB-028746
NSC15947
NSC49396
MFCD00186760
AKOS001057138
LS-09968
Acetamide, N,N'-p-phenylenebis[2-chloro-
H37911
4-13-00-00141 (Beilstein Handbook Reference)
SR-01000035509
SR-01000035509-1