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N-(4-Dimethylsulfamoylphenyl)-2-chloroacetamide

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Identification
Molecular formula
C10H13ClN2O3S
CAS number
24390-14-5
IUPAC name
2-chloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide
State
State
The compound exists as a solid at room temperature, typically forming crystals.
Melting point (Celsius)
129.00
Melting point (Kelvin)
402.15
Boiling point (Celsius)
402.00
Boiling point (Kelvin)
675.15
General information
Molecular weight
264.74g/mol
Molar mass
264.7320g/mol
Density
1.4265g/cm3
Appearence

N-(4-Dimethylsulfamoylphenyl)-2-chloroacetamide appears as a crystalline solid. The crystals may vary in color but are typically off-white to pale yellow. Under the right conditions, the material may take on a more defined crystalline structure.

Comment on solubility

Solubility of 2-chloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide

The solubility of 2-chloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide can be described as follows:

  • Polarity: This compound features both polar and non-polar regions due to the presence of the dimethylsulfamoyl group, which can influence solubility in different solvents.
  • Solvent Compatibility: It is typically expected to have better solubility in polar aprotic solvents such as dimethyl sulfoxide (DMSO) or N,N-dimethylformamide (DMF).
  • Water Solubility: The water solubility is likely limited due to the large hydrophobic phenyl ring and chloro substitution, which can hinder interaction with water molecules.
  • Temperature Influence: Like many organic compounds, solubility may increase with temperature, promoting greater dissolution in chosen solvents.

Overall, while the compound may show moderate solubility in specific solvents, its behavior is influenced by several structural features. As noted, "the balance of hydrocarbon and polar functional groups plays a critical role" in determining solubility profiles.


Understanding the solubility characteristics of 2-chloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide is crucial for its application in various chemical processes and formulations.

Interesting facts

Interesting Facts about 2-Chloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide

2-Chloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide is a fascinating chemical compound with various applications in the field of medicinal chemistry. Known for its structural complexity, it showcases the versatility of organic molecules in pharmaceutical development.

Key Characteristics:

  • Structural Innovation: The compound features a unique combination of a chloro group and a dimethylsulfamoyl moiety, making it a notable example of how substituents can significantly alter a compound's reactivity and biological activity.
  • Pharmacological Potential: Compounds like this are often investigated for their inhibitory effects on certain biological pathways, highlighting the importance of amides in drug design.
  • Research Interest: Due to its linked aromatic ring and functional groups, this compound serves as a model for studying interactions within biological systems, aiding in the understanding of structure-activity relationships (SAR).

This compound underscores the intricate dance between structure and function in chemistry. As researchers explore its properties, collaboration between chemists and biologists is essential to unlock its full potential. Remember, in the world of chemistry, even the smallest differences in a compound can lead to *dramatic variations* in behavior and applications!

Overall, the exploration of 2-chloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide not only enhances our knowledge of chemical interactions but also opens doors to innovative therapeutic strategies.

Synonyms
23280-39-9
ACETANILIDE, 2-CHLORO-4'-(DIMETHYLSULFAMOYL)-
2-Chloro-4'-(dimethylsulfamoyl)acetanilide
PA9ZCG78JX
NSC-137237
DTXSID20177849
RefChem:1075460
DTXCID30100340
2-chloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide
2-Chloro-N-(4-dimethylsulfamoyl-phenyl)-acetamide
Acetamide, 2-chloro-N-[4-[(dimethylamino)sulfonyl]phenyl]-
MFCD01671425
2-chloro-N-{4-[(dimethylamino)sulfonyl]phenyl}acetamide
2-Chloro-N-(4-(N,N-dimethylsulfamoyl)phenyl)acetamide
2-Chloro-N-[4-[(dimethylamino)sulfonyl]phenyl]acetamide
NSC 137237
BRN 2990830
NSC137237
2-Chloro-N-{4-[(dimethylamino)sulfonyl]-phenyl}acetamide
UNII-PA9ZCG78JX
N(sup 4)-Monocloracetilamino-N(sup 1)-dimetil-benzenesulfonamida [Romanian]
ALBB-002461
N(sup 4)-Monocloracetilamino-N(sup 1)-dimetil-benzenesulfonamida
BBL034324
STK502490
AKOS000122497
NCGC00661221-01
VS-12477
CS-0307733
EN300-05987
G31206
SR-01000044912
SR-01000044912-1
Z56928962