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Clomipramine

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Identification
Molecular formula
C10H10ClNO2
CAS number
74-11-3
IUPAC name
2-chloro-N-(4-methoxyphenyl)prop-2-enamide
State
State

Solid

At room temperature, the compound exists in a solid state, typically as a crystalline solid or powder. It is stable under normal conditions.

Melting point (Celsius)
74.00
Melting point (Kelvin)
347.15
Boiling point (Celsius)
408.80
Boiling point (Kelvin)
681.95
General information
Molecular weight
207.65g/mol
Molar mass
207.6490g/mol
Density
1.2410g/cm3
Appearence

At room temperature, this compound appears as a pale yellow crystalline solid. It may also appear as a powder, and is generally characterized by its crystalline structure.

Comment on solubility

Solubility of 2-chloro-N-(4-methoxyphenyl)prop-2-enamide

The solubility of 2-chloro-N-(4-methoxyphenyl)prop-2-enamide can be influenced by various factors, given its unique chemical structure. Here are some key points to consider:

  • Polar vs. Nonpolar: The presence of the polar amide functional group generally suggests a degree of solubility in polar solvents such as water.
  • Organic Solvents: The methoxy group and the chloro substituent may also allow for significant solubility in organic solvents, including ethanol and acetone.
  • Temperature Effects: Like many organic compounds, its solubility may increase with temperature; therefore, heating the solvent can enhance dissolution.
  • Aqueous Solutions: However, the compound's propensity to interact with water is not definitive, potentially leading to low solubility in aqueous solutions.
  • pH Considerations: The solubility of amides is sometimes pH-dependent; thus, alterations in acidity or basicity of the solution could significantly modify solubility.

In conclusion, while it is anticipated that 2-chloro-N-(4-methoxyphenyl)prop-2-enamide demonstrates some solubility in polar solvents due to its polar characteristics, further empirical studies are essential to ascertain the precise solubility profile under varying conditions.

Interesting facts

Interesting Facts about 2-chloro-N-(4-methoxyphenyl)prop-2-enamide

2-chloro-N-(4-methoxyphenyl)prop-2-enamide is a fascinating compound that finds application in various fields of chemistry and medicine. Here are some interesting facts about it:

  • Synthetic Versatility: This compound can be synthesized using various methodologies, making it a valuable building block in organic synthesis. It allows chemists to explore diverse reaction pathways.
  • Role in Medicinal Chemistry: Compounds containing the prop-2-enamide moiety are often studied for their potential pharmaceutical properties, which include anti-inflammatory and anticancer activities.
  • Chirality and Isomerism: This compound has the potential to exist in different isomeric forms, which can lead to variations in biological activity. This aspect of chirality is crucial in drug development for optimizing efficacy and safety.
  • Functional Group Importance: The presence of both chloro and methoxy groups enhances the compound's reactivity and solubility, making it a prime candidate for further functionalization.
  • Research Applications: Being a part of many synthetic routes, this compound is often utilized in research laboratories for exploring new pharmacologically relevant compounds, thereby contributing to advancements in medicinal chemistry.

As a scientist or chemistry student, exploring 2-chloro-N-(4-methoxyphenyl)prop-2-enamide provides insight into the intricacies of organic synthesis and its significance in drug discovery. The study of such compounds not only enhances our understanding of chemical interactions but also propels the field of medicinal chemistry forward.

Synonyms
ACRYLANILIDE, 2-CHLORO-4'-METHOXY-
2-Chloro-4'-methoxyacrylanilide
BRN 2641853
p-Metossi-alpha-cloroacrilanilide
p-Metossi-alpha-cloroacrilanilide [Italian]
20172-02-5
DTXSID10174004
DTXCID4096495
RefChem:317182
SCHEMBL10717672