Skip to main content

2-chloro-N-(4,5-dichloro-2-iodo-phenyl)acetamide

ADVERTISEMENT
Identification
Molecular formula
C8H5Cl3INO
CAS number
356783-16-5
IUPAC name
2-chloro-N-(4,5-dichloro-2-iodo-phenyl)acetamide
State
State

At room temperature, 2-chloro-N-(4,5-dichloro-2-iodo-phenyl)acetamide exists as a solid. The compound does not have significant volatility under standard environmental conditions.

Melting point (Celsius)
174.00
Melting point (Kelvin)
447.15
Boiling point (Celsius)
332.00
Boiling point (Kelvin)
605.15
General information
Molecular weight
364.39g/mol
Molar mass
364.3910g/mol
Density
1.8900g/cm3
Appearence

2-chloro-N-(4,5-dichloro-2-iodo-phenyl)acetamide is typically observed as a solid compound under standard conditions. The color of the solid can range from white to off-white, depending on the purity and specific synthesis pathway used. It is generally crystalline in nature.

Comment on solubility

Solubility of 2-chloro-N-(4,5-dichloro-2-iodo-phenyl)acetamide

The solubility of 2-chloro-N-(4,5-dichloro-2-iodo-phenyl)acetamide in various solvents can provide valuable insight into its potential applications and behaviors in chemical processes. This compound has notable structural complexity due to the presence of multiple halogen substituents, which significantly influence its solubility properties.

Key Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups (like the acetamide moiety) can enhance solubility in polar solvents.
  • Hydrophobic Interactions: The halogen atoms can increase hydrophobic character, potentially leading to reduced solubility in water.
  • Solvent Compatibility: The compound may exhibit better solubility in organic solvents such as dimethyl sulfoxide (DMSO) or acetone compared to aqueous environments.

In general, the solubility of halogenated compounds like 2-chloro-N-(4,5-dichloro-2-iodo-phenyl)acetamide tends to be lower in water due to their hydrophobic nature. As a result, “like dissolves like” becomes a crucial principle when predicting its solubility in various media. It is advisable to conduct empirical testing to determine the specific solubility limits in different solvents, which can vary significantly based on ionic and molecular interactions.

Interesting facts

Interesting Facts about 2-chloro-N-(4,5-dichloro-2-iodo-phenyl)acetamide

2-chloro-N-(4,5-dichloro-2-iodo-phenyl)acetamide is a fascinating organic compound that belongs to the class of amides. This compound has attracted attention in the realm of medicinal chemistry due to its potential applications. Here are some noteworthy aspects:

  • Synthetic Pathway: The synthesis of this compound often involves halogenation and acylation reactions, which can be challenging yet rewarding in terms of yield and purity.
  • Biological Activity: Compounds containing halogens are known for their diverse biological activities. This particular amide has been studied for its potential as a pharmaceutical agent, with research exploring its inhibitory effects on certain enzymes and its role as a scaffold in drug design.
  • Environmental Impact: Halogenated compounds can have significant environmental implications. It is crucial to understand how such compounds interact with biological systems and the ecosystem, tending to focus on reducing their toxicity and improving environmental safety.
  • Structure-Activity Relationship (SAR): The presence of chlorine and iodine atoms in its structure leads to modifications in the compound's pharmacokinetics and pharmacodynamics, making SAR a vital area of study in optimizing its efficacy and safety.
  • Research Opportunities: Ongoing studies involving this compound often lead to the discovery of new derivatives and their potential use in treating diseases, making it a promising subject for further investigation in organic and medicinal chemistry.

In summary, 2-chloro-N-(4,5-dichloro-2-iodo-phenyl)acetamide is more than just a chemical entity; it represents a significant stepping stone in the pursuit of developing new therapeutic agents and understanding the intricate relationships between molecular structure and biological activity.

Synonyms
2'-Iodo-2,4',5'-trichloroacetanilide
23543-02-4
BRN 2115452
ACETANILIDE, 2'-IODO-2,4',5'-TRICHLORO-
DTXSID50178127
RefChem:315691
DTXCID80100618
ACETANILIDE,2-IODO-2,4,5-TRICHLORO-