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Clocortolone

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Identification
Molecular formula
C13H16Cl3NO
CAS number
39718-06-4
IUPAC name
2-chloro-N-[(5-chloro-2-ethoxy-phenyl)methyl]-N-(2-chloroethyl)ethanamine
State
State

At room temperature, clocortolone is typically in a solid crystalline state. It can be processed into medication in cream or ointment form for topical application.

Melting point (Celsius)
118.00
Melting point (Kelvin)
391.15
Boiling point (Celsius)
270.00
Boiling point (Kelvin)
543.15
General information
Molecular weight
279.15g/mol
Molar mass
279.1540g/mol
Density
1.2812g/cm3
Appearence

Clocortolone is a white to off-white crystalline powder. It is typically supplied in its topical formulation as an ointment or cream for dermatological use.

Comment on solubility

Solubility of 2-chloro-N-[(5-chloro-2-ethoxy-phenyl)methyl]-N-(2-chloroethyl)ethanamine

The solubility characteristics of 2-chloro-N-[(5-chloro-2-ethoxy-phenyl)methyl]-N-(2-chloroethyl)ethanamine are influenced by its complex structure, which includes both hydrophilic and hydrophobic components. Understanding its solubility provides insight into its potential applications in various fields. Here are some key points to consider:

  • Hydrophilicity and Hydrophobicity: The presence of the ethoxy group contributes to hydrophilic interactions; however, the chlorinated phenyl and ethyl groups introduce hydrophobic characteristics. This duality often results in limited solubility in water, suggesting it may favor organic solvents.
  • Solvent Compatibility: Solubility tends to increase in organic solvents such as ethanol, acetone, or dichloromethane, while showing reduced solubility in polar solvents (e.g., water).
  • Structural Influence: The addition of chlorine substituents may create steric hindrance, which can also affect the solubility properties through interactions with solvent molecules.

In summary, while 2-chloro-N-[(5-chloro-2-ethoxy-phenyl)methyl]-N-(2-chloroethyl)ethanamine exhibits a complex solubility profile, its potential for integration into different solvent systems is worth exploring, especially in organic chemistry applications. Understanding such behaviors is crucial for synthetic procedures and formulation development.

Interesting facts

Interesting Facts about 2-chloro-N-[(5-chloro-2-ethoxy-phenyl)methyl]-N-(2-chloroethyl)ethanamine

This compound is a fascinating example of a synthetic organic compound, showcasing the intricate relationship between structure and function in medicinal chemistry. Here are some noteworthy insights about it:

  • Pharmacological Potential: Compounds that contain chloroalkyl and aromatic moieties often exhibit significant biological activity, making them of interest in pharmaceutical research.
  • Structure-Activity Relationship (SAR): The presence of multiple chlorinated groups in the compound may influence its interaction with biological targets, leading to unique pharmacological profiles.
  • Synthetic Routes: The synthesis of such compounds often involves multi-step organic reactions that require precise control of conditions and reagents, reflecting the complexity of modern organic synthesis.
  • Applications: Investigating similar compounds can lead to advancements in medicinal chemistry, particularly in areas like anticancer research and the design of novel drugs.

As a chemistry student, you might appreciate the compound’s potential role in drug discovery and development. As stated by renowned chemists, "The structure of a molecule is crucial to determining its biological activity." Analyzing compounds like this one can enhance your understanding of how slight modifications can lead to vastly different effects within biochemical systems.

Additionally, studying this compound highlights the important ethical considerations in drug development, as researchers must ensure that new compounds are not only effective but also safe for human use. Its chlorinated structure presents both opportunities and challenges in terms of toxicity and environmental impact, making it a critical area of investigation for chemists.

Synonyms
Benzenemethanamine, 5-chloro-N,N-bis(2-chloroethyl)-2-ethoxy-
64295-09-6
5-Chloro-N,N-bis(2-chloroethyl)-2-ethoxybenzenemethanamine
DTXSID70214516