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2-Chloro-N-phenylacetamide

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Identification
Molecular formula
C8H8ClNO
CAS number
632-21-1
IUPAC name
2-chloro-N-phenyl-acetamide
State
State

At room temperature, 2-Chloro-N-phenylacetamide exists in a solid state. It is often found in a crystalline form, making it stable for various applications and storages.

Melting point (Celsius)
94.50
Melting point (Kelvin)
367.70
Boiling point (Celsius)
273.00
Boiling point (Kelvin)
546.00
General information
Molecular weight
169.61g/mol
Molar mass
169.6060g/mol
Density
1.3010g/cm3
Appearence

2-Chloro-N-phenylacetamide appears as a white or off-white crystalline solid. Its solid form maintains a powdered or crystalline texture, which can be described further based on the crystal size and purity.

Comment on solubility

Solubility of 2-chloro-N-phenyl-acetamide

The solubility of 2-chloro-N-phenyl-acetamide (C9H10ClN1O1) can be intriguing due to its chemical structure. This compound contains both hydrophobic (phenyl) and hydrophilic (amido) groups, leading to a unique balance in solubility characteristics.

When considering the solubility of 2-chloro-N-phenyl-acetamide, the following points are noteworthy:

  • Polarity: The presence of the amide group contributes to its ability to interact with polar solvents, such as water, albeit to a limited extent.
  • Solvent Choice: It may dissolve more readily in organic solvents like ethanol, acetone, or dichloromethane than in water due to the hydrophobic nature of the phenyl ring.
  • Temperature Effect: Solubility may increase with temperature, allowing for better dissolution in certain solvents when heated.

As a general rule, one might say, "Like dissolves like." Therefore, understanding the balance between hydrophobic and hydrophilic properties is crucial for predicting the solubility of 2-chloro-N-phenyl-acetamide.

In summary, while 2-chloro-N-phenyl-acetamide exhibits some solubility in water, it is more favorable in polar organic solvents. Comprehensive testing is suggested for specific applications in research and industry.

Interesting facts

Interesting Facts about 2-Chloro-N-phenyl-acetamide

2-Chloro-N-phenyl-acetamide is a fascinating compound that possesses a variety of applications and intriguing characteristics. Often utilized in the field of medicinal chemistry, it plays a vital role as a building block in the synthesis of pharmaceutical agents. Here are some key points that highlight the significance of this compound:

  • Pharmaceutical Relevance: This compound is frequently explored for its potential therapeutic effects, particularly in the development of analgesics and anti-inflammatory drugs.
  • Structure-Activity Relationship (SAR): The presence of the chloro group significantly affects the compound's biological activity, providing a rich area for research into how structural modifications alter efficacy.
  • Functional Group Influence: The amide functional group is known for its ability to form hydrogen bonds, which enhances solubility and bioavailability of the derived compounds in biological systems.
  • Synthetic Pathways: There are various synthetic methods for producing 2-chloro-N-phenyl-acetamide, ranging from straightforward acylation reactions to more complex multi-step routes, showcasing the compound's versatility.

Furthermore, it's noteworthy that compounds like 2-chloro-N-phenyl-acetamide can serve as intermediates in the synthesis of more complex molecules, demonstrating the interconnectedness of chemical processes in crafting novel therapeutics. This highlights the essential role of chemists in innovating solutions for modern medical challenges.

As scientists continue to explore its properties, 2-chloro-N-phenyl-acetamide remains a promising subject for future studies, potentially leading to groundbreaking discoveries in drug development.

Synonyms
2-CHLORO-N-PHENYLACETAMIDE
2-Chloroacetanilide
Chloroacetanilide
Acetamide, 2-chloro-N-phenyl-
chloracetanilide
HSDB 1411
.omega.-Chloroacetanilide
EINECS 209-604-0
UNII-2R6RM9R0W8
BRN 0509684
DTXSID3041409
AI3-01088
NSC-311
N-(Chloroacetyl)aniline
N-Phenyl-2-chloroethanamide
DTXCID1021409
PHENYLCARBAMOYLMETHYL CHLORIDE
ACETANILIDE, .ALPHA.-CHLORO-
.ALPHA.-CHLORO-N-PHENYLACETAMIDE
2-CHLORO-N-PHENYLACETAMIDE [HSDB]
2Chloroacetanilide
NPhenylchloroacetamide
Acetanilide, 2chloro
NPhenyl2chloroacetamide
Acetamide, 2chloroNphenyl
OMEGA-CHLOROACETANILIDE
ACETANILIDE, ALPHA-CHLORO-
ALPHA-CHLORO-N-PHENYLACETAMIDE
Acetamide, 2-chloro-N-phenyl-(9CI)
209-604-0
4-12-00-00377 (beilstein handbook reference)
vonwpexrclhkrj-uhfffaoysa-n
587-65-5
N-Phenylchloroacetamide
N-Phenyl-2-chloroacetamide
Acetanilide, 2-chloro-
.alpha.-Chloroacetanilide
NSC 311
MFCD00018887
N-(2-chloroacetyl)aniline
2R6RM9R0W8
chloroacetylaniline
2-chloro-acetanilide
N-Chloroacetylaniline
omega-chloracetanilide
alpha-Chloracetanilide
alpha-Chloroacetanilide
alpha-chloroacetoanilide
N-phenyl chloroacetamide
WLN: G1VMR
N-phenyl-2-chloro-acetamid
2-chloro-N-phenyl-acetamide
N-(2-chloroacetyl)-aniline
2-Chloro-N-phenyl acetamide
SCHEMBL44662
NSC311
CHEMBL2164307
JS-102C
2-Chloro-N-phenylacetamide, 97%
AAA58765
ALBB-002246
Tox21_300983
STK115910
AKOS000283503
NCGC00248243-01
NCGC00254885-01
CAS-587-65-5
PD138947
SY025153
8,8-dimethylpyrano[3,2-g]chromen-2-one
DB-020905
CS-0079929
NS00022431
EN300-01744
W18660
Q27255499
Z56889119