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N-(2-chloroethyl)-N-ethyl-9H-fluoren-9-amine;hydrochloride

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Identification
Molecular formula
C17H19Cl2N
CAS number
27247-07-0
IUPAC name
2-chloroethyl-ethyl-(9H-fluoren-9-yl)ammonium;chloride
State
State

At room temperature, N-(2-chloroethyl)-N-ethyl-9H-fluoren-9-amine;hydrochloride is typically a solid.

Melting point (Celsius)
163.00
Melting point (Kelvin)
436.15
Boiling point (Celsius)
290.50
Boiling point (Kelvin)
563.65
General information
Molecular weight
287.21g/mol
Molar mass
287.2110g/mol
Density
1.1100g/cm3
Appearence

N-(2-chloroethyl)-N-ethyl-9H-fluoren-9-amine;hydrochloride appears as a white crystalline solid, typical of many aromatic amine salts. It is generally a fine powder and can be somewhat hygroscopic, absorbing water from the air under high humidity conditions.

Comment on solubility

Solubility of 2-chloroethyl-ethyl-(9H-fluoren-9-yl)ammonium;chloride

The solubility characteristics of 2-chloroethyl-ethyl-(9H-fluoren-9-yl)ammonium;chloride can be intriguing due to its complex structure. Generally, compounds that contain ammonium groups tend to be more soluble in polar solvents. In this case, the presence of a quaternary ammonium group enhances solubility in water, as such groups can engage in favorable interactions with water molecules.

Key factors influencing its solubility include:

  • Polarity: The polar nature of the ammonium chloride group can facilitate dissolution in polar solvents.
  • Hydrogen bonding: The ability to form hydrogen bonds with water molecules increases its solubility.
  • Chain length: The presence of bulky aryl groups (like the fluorenyl group) may hinder solubility to some extent, but overall, the polar substituents often dominate in solubility behavior.

It is often noted that "like dissolves like" which applies here, suggesting that this compound would exhibit better solubility in polar solvents rather than non-polar environments. Optimizing conditions such as temperature and solvent choice can further improve the solubility of this compound.

Interesting facts

Interesting Facts about 2-Chloroethyl-Ethyl-(9H-Fluoren-9-yl)Ammonium Chloride

2-Chloroethyl-Ethyl-(9H-Fluoren-9-yl)Ammonium Chloride is a fascinating compound with significant applications in various fields. Here are some noteworthy points about this intriguing ammonium salt:

  • Pharmaceutical Applications: This compound has shown potential in medicinal chemistry, where its unique structure can lead to the development of novel therapeutic agents. The 9H-fluoren-9-yl group is particularly interesting due to its role in enhancing biological activity.
  • Ammonium Salts: As an ammonium salt, it exhibits properties typical of quaternary ammonium compounds, which are well-known for their use as disinfectants and surfactants. Its quaternization contributes to its solubility and reactivity, making it a valuable intermediary in organic synthesis.
  • Structure-Activity Relationship (SAR): The structure of this compound provides an excellent framework for studying the SAR, where modifications to the fluorenyl moiety or the chloroethyl group can drastically alter the biological activity and selectivity of the resulting compounds.
  • Research Significance: Compounds with such complex structures are often subjects of intense research, providing insights into their mechanisms of action and potential applications in drug discovery and development. Scientists are keen to explore how modifications can lead to enhanced efficacy against specific targets.

In summary, 2-Chloroethyl-Ethyl-(9H-Fluoren-9-yl)Ammonium Chloride is much more than just a chemical formula; it represents a bridge between chemistry and real-world applications, illustrating the profound relationships between molecular structure and biological function. As researchers continue to unravel its potential, this compound stands as a testament to the endless possibilities within the realm of chemical research.

Synonyms
2-Chloro-N-(9-fluorenyl)diethylamine hydrochloride
13929-01-6
SKF-501 hydrochloride
Diethylamine, 2-chloro-N-(9-fluorenyl)-, hydrochloride
N-(2-Chloroethyl)-N-ethylfluoren-9-amine hydrochloride
N-(9-Fluorenyl)-N-ethyl-beta-chloroethylamine hydrochloride
9H-Fluoren-9-amine, N-(2-chloroethyl)-N-ethyl-, hydrochloride
FLUOREN-9-AMINE, N-(2-CHLOROETHYL)-N-ETHYL-, HYDROCHLORIDE