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2-(Chloromethyl)quinoline

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Identification
Molecular formula
C10H8ClN
CAS number
612-68-4
IUPAC name
2-(chloromethyl)quinoline
State
State

At room temperature, 2-(Chloromethyl)quinoline is in a liquid state, which is often slightly viscous and pale yellow.

Melting point (Celsius)
-20.00
Melting point (Kelvin)
253.15
Boiling point (Celsius)
110.00
Boiling point (Kelvin)
383.15
General information
Molecular weight
175.63g/mol
Molar mass
175.6340g/mol
Density
1.2100g/cm3
Appearence

2-(Chloromethyl)quinoline is typically observed as a pale yellow liquid. It can appear slightly oily in texture and may have a faint odor characteristic of quinoline derivatives.

Comment on solubility

Solubility of 2-(chloromethyl)quinoline

The solubility of 2-(chloromethyl)quinoline in various solvents is an interesting aspect to explore. This compound, characterized by a quinoline structure modified with a chloromethyl group, exhibits varying solubility properties depending on the solvent used.

Key Points on Solubility:

  • Polar Solvents: 2-(chloromethyl)quinoline generally has limited solubility in polar solvents such as water. This is attributed to the hydrophobic nature of the quinoline ring, which hinders interactions with polar molecules.
  • Non-Polar Solvents: It shows significantly higher solubility in non-polar solvents like hexane or chloroform. The non-polar nature of these solvents facilitates better interactions with the compound's hydrophobic structure.
  • Solubility Trends: The presence of the chloromethyl group can also influence solubility, as it introduces a slight polar character that could affect its behavior in mixed solvent systems.

To summarize, the overall solubility of 2-(chloromethyl)quinoline is characterized by its preference for non-polar environments. As with many organic compounds, the choice of solvent is crucial in determining the dissolution behavior of this compound, making it essential to consider the solvent properties for effective applications.

Interesting facts

Interesting Facts about 2-(Chloromethyl)quinoline

2-(Chloromethyl)quinoline is an intriguing compound that belongs to the class of quinolines, which are aromatic heterocycles renowned for their diverse biological activities and applications in medicinal chemistry.

Key Characteristics

  • Biological Relevance: This compound has attracted attention due to its potential as a building block for the synthesis of bioactive molecules. Its structure allows for various modifications that can enhance pharmacological properties.
  • Therapeutic Potential: Compounds derived from quinoline structures are often investigated for their anti-inflammatory, anticancer, and antimicrobial effects. 2-(Chloromethyl)quinoline could serve as a precursor in the development of novel drugs.
  • Versatile Reactivity: The chloromethyl group is a reactive site that can participate in nucleophilic substitutions, making this compound a valuable intermediate in organic synthesis.

Applications in Research and Industry

This compound is not only of interest in the laboratory but also in various industrial applications:

  • Synthetic Chemistry: It is often employed in the synthesis of advanced materials and functionalized polymers.
  • Agricultural Chemistry: Research is being conducted to explore its potential as a pesticide or herbicide component, leveraging its biological activity against pests.

In Summary

As you can see, 2-(chloromethyl)quinoline exemplifies the interplay between structure and function in chemistry. As noted by scientists, “Understanding the reactivity of chloromethyl groups expands our toolkit for synthesizing complex molecules.” This compound serves as a reminder of the importance of chemical innovation in addressing current and future challenges in healthcare and materials science.

Synonyms
2-(Chloromethyl)quinoline
4377-41-7
EINECS 224-479-2
DTXSID70195932
NSC 158442
DTXCID10118423
224-479-2
2-Chloromethylquinoline
chloromethylquinoline
MFCD00023999
2-Chloromethyquinoline
2-chloromethyiquinoline
2-chloromethyl quinolin
2quinolinylmethylchloride
2-chloromethyl-quinoline
2-Chloromethyl quinoline
2-quinolinylmethylchloride
2-chloro methyl quinoline
2- (chloromethyl)quinoline
2-(chloro methyl)quinoline
2-(chloromethyl) quinoline
SCHEMBL498405
Quinoline, 2-(chloromethyl)-
2-(CHLOROMETHYL)-QUINOLINE
BCP22822
NSC158442
AKOS015850529
AB01399
BCP9000080
NSC-158442
s11826
AC-27318
AS-77032
NS00031365