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2'-Chloro-4-methylbenzophenone

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Identification
Molecular formula
C14H11ClO
CAS number
7463-51-6
IUPAC name
(2-chlorophenyl)-(p-tolyl)methanone
State
State

At room temperature, 2'-Chloro-4-methylbenzophenone is in a solid state.

Melting point (Celsius)
82.00
Melting point (Kelvin)
355.15
Boiling point (Celsius)
348.00
Boiling point (Kelvin)
621.15
General information
Molecular weight
232.70g/mol
Molar mass
232.6980g/mol
Density
1.1870g/cm3
Appearence

2'-Chloro-4-methylbenzophenone appears as a white to slightly yellow crystalline solid. It has a distinct aromatic odor.

Comment on solubility

Solubility of (2-chlorophenyl)-(p-tolyl)methanone

The solubility of (2-chlorophenyl)-(p-tolyl)methanone can be seen as a balance between its molecular structure and the solvent properties. Here are some key points to consider:

  • Polarity: The presence of the chlorine atom in the 2-chlorophenyl group imparts some polar characteristic, while the p-tolyl group remains largely non-polar. This *diverse polarity* can lead to moderate solubility behaviors.
  • Solvents: Typically, (2-chlorophenyl)-(p-tolyl)methanone is more soluble in organic solvents like ethanol, ether, and benzene, as opposed to being soluble in water.
  • Temperature Dependence: Solubility may increase with temperature; thus, higher temperatures can often facilitate better dissolution in organic solvents.
  • Hydrophobic Interactions: The non-polar p-tolyl portion tends to exhibit strong hydrophobic interactions, which can affect the compound’s overall solubility profile.

As a rule of thumb, “like dissolves like” prevails, where polar solvents will effectively dissolve polar compounds, while non-polar solvents excel with non-polar compounds. Therefore, researchers should always take into consideration the solvent's characteristics when predicting the solubility of (2-chlorophenyl)-(p-tolyl)methanone.

Interesting facts

Interesting Facts about (2-chlorophenyl)-(p-tolyl)methanone

(2-chlorophenyl)-(p-tolyl)methanone, often referred to in the literature by its IUPAC name, is a fascinating compound with a range of intriguing characteristics:

  • Structure and Substitution: This organic compound features a ketone functional group along with two aromatic rings. The presence of both a 2-chlorophenyl group and a p-tolyl group results in a compound that exemplifies the concept of ortho- and para-substitution in aromatic chemistry.
  • Applications: Compounds of this type are often investigated for their potential in various applications, including:
    • Pharmaceuticals
    • Agricultural chemicals
    • Research in organic synthesis
  • Reactivity: The chlorine substituent on the aromatic ring can significantly affect the compound's reactivity, particularly in electrophilic substitution reactions. Chlorinated compounds are often more reactive towards nucleophiles, making them important intermediates in synthetic chemistry.
  • Biological Relevance: Some chlorinated aromatic compounds have been studied for their biological activity. Understanding how (2-chlorophenyl)-(p-tolyl)methanone interacts with biological systems could lead to the discovery of new therapeutic agents.
  • Research Potential: The study of compounds such as (2-chlorophenyl)-(p-tolyl)methanone can provide insight into:
    • Reaction mechanisms in organic chemistry
    • The development of more efficient synthetic pathways
    • Structure-activity relationships in drug design

This compound is an excellent example of how variations in chemical structure can lead to diverse properties and functionalities, making it a topic of interest among chemists and chemical engineers alike.

Synonyms
5953-00-4
2-Chloro-4'-methylbenzophenone
(2-chlorophenyl)(4-methylphenyl)methanone
(2-chlorophenyl)-(4-methylphenyl)methanone
Methanone, (2-chlorophenyl)(4-methylphenyl)-
BENZOPHENONE, 2-CHLORO-4'-METHYL-
NSC-10205
NSC 10205
BRN 2577684
NSC10205
MFCD01463397
4-07-00-01404 (Beilstein Handbook Reference)
SCHEMBL195683
DTXSID70208218
62484FS8TW
(2-Chlorophenyl)(p-tolyl)methanone
FAA95300
(2-chlorophenyl)-(p-tolyl)methanone
AKOS009346646
CCG-325538
CS-0262322
EN300-82123
G32003
AE-562/12222203
Z385421216