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Clomipramine Hydrochloride

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Identification
Molecular formula
C19H24ClN3O
CAS number
17321-77-6
IUPAC name
(2-chlorophenyl)methyl-[3-[[2-[3-[(2-chlorophenyl)methyl-diethyl-ammonio]propylamino]-2-oxo-acetyl]amino]propyl]-diethyl-ammonium;dichloride
State
State

At room temperature, Clomipramine hydrochloride is typically in a solid state. It is stable under normal conditions of use and storage.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.15
Boiling point (Celsius)
564.17
Boiling point (Kelvin)
837.32
General information
Molecular weight
314.86g/mol
Molar mass
314.8600g/mol
Density
1.0696g/cm3
Appearence

Clomipramine hydrochloride typically appears as a white or slightly cream-colored crystalline powder. It may also be found in a form suitable for oral or injectable drug formulations, where it is generally odorless or almost odorless.

Comment on solubility

Solubility of (2-chlorophenyl)methyl-[3-[[2-[3-[(2-chlorophenyl)methyl-diethyl-ammonio]propylamino]-2-oxo-acetyl]amino]propyl]-diethyl-ammonium;dichloride

The solubility of the compound (2-chlorophenyl)methyl-[3-[[2-[3-[(2-chlorophenyl)methyl-diethyl-ammonio]propylamino]-2-oxo-acetyl]amino]propyl]-diethyl-ammonium;dichloride can be characterized by several key points:

  • Polar Nature: Given the presence of multiple ammonium groups within the molecular framework, the compound exhibits significant polar characteristics which enhance its affinity for polar solvents.
  • Solvent Interaction: The solubility is likely to be higher in polar solvents such as water, dimethyl sulfoxide (DMSO), and methanol due to the ionic interactions facilitated by the ammonium groups.
  • Influence of Chloride Ions: The dichloride component not only adds to the ionic nature of the compound but may also affect solubility by promoting ion-dipole interactions in solution.
  • Temperature Consideration: Solubility may vary with temperature; generally, increasing temperatures lead to increased solubility in many compounds, particularly those with polar characteristics.

In summary, while specific solubility data for this complex compound may not be readily available, it can be inferred that its ionic and polar nature suggests compatibility with polar solvents, enhancing its solubility profile. As always, experimentation is important to identify precise solubility parameters. In the world of chemical compounds, understanding solubility can be a fascinating blend of theory and practice!

Interesting facts

Interesting Facts about (2-chlorophenyl)methyl-[3-[[2-[3-[(2-chlorophenyl)methyl-diethyl-ammonio]propylamino]-2-oxo-acetyl]amino]propyl]-diethyl-ammonium;dichloride

This compound is a fascinating example of a synthetic organic molecule with significant implications in medicinal chemistry. Here are some intriguing aspects to consider:

  • Structural Complexity: The compound features multiple functional groups, including amine and carbonyl groups, which contribute to its potential reactivity and interactions with biological systems. The presence of the dichloride salt indicates a possibility of enhanced solubility and stability in various formulations.
  • Pharmacological Potential: The compound's structure suggests it may exhibit activities as a pharmacological agent. Compounds with similar structures have shown promise in therapeutic areas such as oncology and neuropharmacology.
  • Ammonium Ions: The presence of quaternary ammonium ions, arising from diethylammonium moieties, can impart unique biological characteristics, such as membrane permeability and binding affinity to various receptors, making it an interesting target for drug design.
  • Chlorine Substituents: The chlorophenyl groups may enhance lipophilicity and stereoelectronic properties of the compound, potentially increasing its efficacy and selective action at the molecular level.

As a chemist or student studying the intricacies of organic compounds, it's crucial to analyze the interactions and behaviors of such complex molecules. As John Dalton once said, "All matter is composed of atoms; to understand matter, we must first understand the elements that compose it." Exploring molecules like this one brings us closer to that goal.

In summary, (2-chlorophenyl)methyl-[3-[[2-[3-[(2-chlorophenyl)methyl-diethyl-ammonio]propylamino]-2-oxo-acetyl]amino]propyl]-diethyl-ammonium;dichloride embodies the richness of organic synthesis and the promise it holds for future medicinal applications.

Synonyms
WIN 8626
152-24-9
AMMONIUM, (OXALYLBIS(IMINOTRIMETHYLENE))BIS((o-CHLOROBENZYL)DIETHYL-, DICHLORIDE
(Oxalylbis(iminotrimethylene))bis((o-chlorobenzyl)diethylammonium chloride)