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2-Cyanoacetamide

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Identification
Molecular formula
C3H4N2O
CAS number
107-91-5
IUPAC name
2-cyanoacetamide
State
State

At room temperature, 2-Cyanoacetamide is typically in a solid state. It remains stable as a crystalline solid under normal conditions but can be subject to melting or decomposition if exposed to higher temperatures during processing or experimentation.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
297.00
Boiling point (Kelvin)
570.15
General information
Molecular weight
84.09g/mol
Molar mass
84.0880g/mol
Density
1.1490g/cm3
Appearence

2-Cyanoacetamide appears as a white crystalline solid. Its crystalline nature can make it look like a fine powder and it's relatively stable under standard conditions. It usually appears in an off-white color if impurities are present.

Comment on solubility

Solubility of 2-Cyanoacetamide

2-cyanoacetamide, known for its versatile applications in chemical synthesis, exhibits interesting solubility characteristics. This compound is typically soluble in polar solvents due to its organic nature and the presence of both cyano (-C≡N) and amide (-CONH2) functional groups. More specifically:

  • Water: 2-cyanoacetamide is moderately soluble in water, primarily because of its ability to form hydrogen bonds with water molecules.
  • Alcohols: This compound readily dissolves in alcohols, such as ethanol, due to similar polar characteristics.
  • Aromatic solvents: It also shows solubility in various aromatic solvents, which can be attributed to π-π stacking interactions and dipole-dipole interactions.

However, it is important to note that solubility can be affected by temperature; as temperature increases, solubility generally improves. Therefore, when working with 2-cyanoacetamide in synthetic environments, it is prudent to consider these solubility traits to optimize reactions and product recovery. Overall, the solubility profile of 2-cyanoacetamide offers a conducive foundation for its utility in numerous chemical processes.

Interesting facts

Interesting Facts about 2-Cyanoacetamide

2-Cyanoacetamide is an intriguing organic compound featured prominently in various chemical research and industrial applications. Here are some compelling insights into this compound:

  • Versatile Intermediate: 2-Cyanoacetamide serves as an essential building block in the synthesis of various pharmaceuticals and agrochemicals, making it invaluable in medicinal chemistry.
  • Reactivity: The presence of both a cyano and an amide functional group within its structure provides unique reactivity patterns. This characteristic allows for diverse chemical reactions, including nucleophilic additions and condensation reactions.
  • Biological Activity: Research indicates that 2-cyanoacetamide derivatives may exhibit various biological activities, including anti-inflammatory and anticancer properties, highlighting its potential in drug discovery.
  • Formation of Heterocycles: This compound is often utilized in the synthesis of heterocyclic compounds, which are crucial in the development of numerous natural products and pharmaceutical agents.
  • Educational Tool: For chemistry students, the study of 2-cyanoacetamide exemplifies key principles of organic chemistry, such as functional group transformations and reaction mechanisms.

As noted by chemists, "The complexities and reactivities of 2-cyanoacetamide illustrate the beauty of organic synthesis." This compound continues to be a point of focus in both academic research and practical application, showcasing the importance of studying small organic molecules.

Synonyms
2-Cyanoacetamide
107-91-5
CYANOACETAMIDE
Acetamide, 2-cyano-
Cyanacetamide
Malonamide nitrile
Malonamonitrile
Nitrilomalonamide
Cyanoiminoacetic acid
3-Nitrilo-propionamide
Propionamide nitrile
Propionamide, 3-nitrilo-
USAF KF-14
Kyanacetamid
cyano acetamide
HSDB 2817
UNII-YBK38G2YXH
Malonic acid, monoamide mononitrile
NSC 6285
2-cyano-acetamide
EINECS 203-531-8
MFCD00008024
alpha-Cyanoacetamide
BRN 0878221
.alpha.-Cyanoacetamide
AI3-20147
Amid kyseliny kyanoctove
NSC-6285
YBK38G2YXH
CYANOACETAMIDE [MI]
CYANOACETAMIDE [HSDB]
CHEMBL2333142
DTXSID2051552
EC 203-531-8
WLN: ZV1CN
Kyanacetamid (czech)
Amid kyseliny kyanoctove (czech)
2cyanoacetamide
2-cyanoacetamid
a-cyanoacetamide
cyanoacetic amide
2-cyanoethanamide
2-cyano acetamide
3Nitrilopropionamide
XHD
alpha-cyano-acetamide
Cyanoacetamide, 99%
Propionamide, 3nitrilo
DTXCID6030104
NSC6285
NSC8948
NSC-8948
BDBM50428735
STK398335
AKOS000118770
FC54903
BP-21030
MALONIC ACID, MONOAMIDE MONONITRILE-
CS-0006665
NS00006407
EN300-17156
W18657
2-cyanoacetamide (en)acetamide, 2-cyano- (en)
Q1146906
Z56896153
F0001-0146
PROPANEDIOIC ACID,MONOAMIDE,MONONITRILE MALONIC ACID,MONOAMIDE,MONONITRILE
PROPANEDIOIC ACID,MONOAMIDE,MONONITRILE MALONIC ACID,MONOAMIDE,MONONITRILE