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Propanolol

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Identification
Molecular formula
C16H21NO
CAS number
525-66-6
IUPAC name
2-(cyclohexylamino)-1-phenyl-propan-1-ol
State
State

At room temperature, propranolol is typically found as a solid.

Melting point (Celsius)
96.00
Melting point (Kelvin)
369.15
Boiling point (Celsius)
444.60
Boiling point (Kelvin)
717.80
General information
Molecular weight
259.36g/mol
Molar mass
259.3640g/mol
Density
1.0637g/cm3
Appearence

Propranolol is typically found as a white to off-white crystalline powder. It is often seen in its hydrochloride salt form for pharmaceutical use, which is also white to off-white in appearance. The powder is usually odorless.

Comment on solubility

Solubility of 2-(cyclohexylamino)-1-phenyl-propan-1-ol

The solubility of 2-(cyclohexylamino)-1-phenyl-propan-1-ol in various solvents can be influenced by several structural characteristics. Here are some key points to consider:

  • Polarity: The presence of both a cyclohexyl group and an amino group suggests that this compound has a moderate level of polarity, which can affect its solubility in polar solvents.
  • Hydrogen Bonding: The amino group can participate in hydrogen bonding, which may enhance solubility in polar solvents such as water, but this is dependent on the balance of hydrophobic and hydrophilic segments in the molecule.
  • Organic Solvents: It is likely that 2-(cyclohexylamino)-1-phenyl-propan-1-ol will exhibit better solubility in organic solvents like ethanol or methanol compared to non-polar solvents due to its structural features.

In conclusion, while specific solubility data may vary, this compound is expected to have:

  1. Good solubility in polar organic solvents.
  2. Moderate solubility in water due to its polar functional groups.
  3. Limited solubility in non-polar solvents.

Understanding these aspects of solubility is crucial for applications in various fields, including pharmaceuticals and organic synthesis.

Interesting facts

Interesting Facts about 2-(cyclohexylamino)-1-phenyl-propan-1-ol

The compound 2-(cyclohexylamino)-1-phenyl-propan-1-ol is a fascinating member of the class of organic compounds known as amines. This compound draws interest in the field of medicinal chemistry and pharmacology due to its potential biological activities and applications. Here are some key points that highlight its significance:

  • Structure and Functionality: The compound features a unique structure incorporating both a cyclohexylamino group and a phenyl group, which play critical roles in its pharmacological profile.
  • Research Interest: 2-(cyclohexylamino)-1-phenyl-propan-1-ol has been studied for its potential neuroprotective effects, making it a subject for research in treatments for neurodegenerative diseases.
  • Design of Drug Molecules: Chemists often investigate such compounds to explore structure-activity relationships (SARs). Understanding how modifications to the amine or phenyl groups affect biological activity can lead to the development of potent therapeutics.
  • Chiral Centers: This compound possesses a chiral center, indicating that it can exist in two enantiomeric forms. This chirality can significantly influence the compound's pharmacodynamics and pharmacokinetics.
  • Versatile Derivatives: There is also potential for synthesizing derivatives of this compound to enhance efficacy and reduce side effects, making it an appealing target for further investigation.

As researchers delve deeper into the properties and mechanisms of action of compounds like 2-(cyclohexylamino)-1-phenyl-propan-1-ol, it exemplifies the intricacies of organic chemistry and the boundless possibilities within pharmaceutical development. It stands as a testament to how a simple modification in chemical structure can lead to profound changes in biological activity, paving the way for innovative therapeutic strategies in medicine.

Synonyms
2053-42-1
2-(cyclohexylamino)-1-phenylpropan-1-ol
SMB 513
1-Phenyl-2-cyclohexylamino-propanol-1
alpha-(1-(Cyclohexylamino)ethyl)benzenemethanol
alpha-(1-(Cyclohexylamino)ethyl)benzyl alcohol
Benzenemethanol, alpha-(1-(cyclohexylamino)ethyl)-
BENZYL ALCOHOL, alpha-(1-(CYCLOHEXYLAMINO)ETHYL)-
DTXSID30942702