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Bupropion

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Identification
Molecular formula
C13H18N2
CAS number
91601-60-6
IUPAC name
2-(cyclohexylamino)-2-methyl-propanenitrile
State
State

At room temperature, bupropion is typically in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
232.00
Melting point (Kelvin)
505.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
206.31g/mol
Molar mass
263.3800g/mol
Density
1.0180g/cm3
Appearence

Bupropion is typically found in its hydrochloride form, which appears as a white, crystalline powder.

Comment on solubility

Solubility of 2-(cyclohexylamino)-2-methyl-propanenitrile

The solubility of 2-(cyclohexylamino)-2-methyl-propanenitrile is influenced by various factors due to its unique structure, which includes both a cyclohexyl group and a nitrile functional group. Understanding its solubility can be crucial for its applications in synthesis and formulation.

Key Points on Solubility:

  • Polarity: The presence of the -C≡N (nitrile) functional group contributes to the polarity of the compound, enhancing its solubility in polar solvents such as water and alcohols.
  • Hydrophobic Character: The cyclohexyl moiety is relatively hydrophobic, often decreasing the solubility in polar solvents. This creates a balance where the solubility can be moderate.
  • Solvent Compatibility: 2-(cyclohexylamino)-2-methyl-propanenitrile generally exhibits better solubility in organic solvents like acetone and ethyl acetate compared to water due to the non-polar characteristics from the cyclohexyl group.
  • Temperature Effects: As with many organic compounds, an increase in temperature can enhance solubility. It's advised to conduct the solubility tests at various temperatures to obtain comprehensive data.

In summary, the solubility of 2-(cyclohexylamino)-2-methyl-propanenitrile is a complex interplay of its functional groups. To fully understand its behavior in different environments, empirical testing is recommended to determine solvent compatibility and the conditions under which it dissolves most effectively.

Interesting facts

Exploring 2-(Cyclohexylamino)-2-methyl-propanenitrile

2-(Cyclohexylamino)-2-methyl-propanenitrile, often referred to in scientific circles as a valuable compound in organic synthesis, has attracted considerable attention due to its unique structural properties and potential applications. Here are some intriguing facts about this fascinating substance:

  • Versatile Synthetic Intermediate: This compound is recognized for its utility as a versatile intermediate in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals.
  • Structural Features: The structure features a cyclohexylamine moiety, which contributes to its physical and chemical characteristics, such as steric hindrance and electronic effects.
  • Biological Activity: Preliminary studies suggest that compounds containing the nitrile functional group can exhibit significant biological activity, making 2-(cyclohexylamino)-2-methyl-propanenitrile a candidate for further exploration in medicinal chemistry.
  • Research Interest: Recent research has focused on derivatives of this compound, exploring modifications that could enhance its activity or reduce toxicity, highlighting the ongoing interest in its potential applications.
  • Application Possibilities: Beyond its role in drug development, this compound may also play a role in the synthesis of polymers, additives, or other functional materials.

In summary, 2-(cyclohexylamino)-2-methyl-propanenitrile stands as an important building block in the realm of organic chemistry, offering a glimpse into the intersection of structural chemistry and biological activity. Its exploration could pave the way for innovations in various scientific fields.

Synonyms
6281-50-1
ACETONITRILE, 2-CYCLOHEXYLAMINO-2-DIMETHYL-
NSC 5795
Propanenitrile, 2-(cyclohexylamino)-2-methyl-
BRN 2690068
2-Cyclohexylamino-2-dimethylacetonitrile
DTXSID80211910
4-12-00-00078 (Beilstein Handbook Reference)
DTXCID10134401
Propanenitrile, 2-(cyclohexylamino)-2-methyl-(9CI)
NSC5795
ACETONITRILE,2-CYCLOHEXYLAMINO-2-DIMETHYL-
2-cyano-2-cyclohexylaminopropane
WLN: L6TJ AMX1&1&CN
NSC-5795
AKOS003615474
2-(Cyclohexylamino)-2-dimethylacetonitrile