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chloroquine

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Identification
Molecular formula
C18H26Cl3N3O
CAS number
54-05-7
IUPAC name
2-(dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)-4-quinolyl]ethanol
State
State

The compound is typically found as a solid at room temperature. In its pure form, it is a crystalline powder, demonstrating significant stability under standard conditions.

Melting point (Celsius)
87.00
Melting point (Kelvin)
360.15
Boiling point (Celsius)
190.00
Boiling point (Kelvin)
463.15
General information
Molecular weight
319.87g/mol
Molar mass
319.8700g/mol
Density
1.2961g/cm3
Appearence

Chloroquine appears as a white to slightly yellow crystalline powder. It is odorless and has a bitter taste. The compound is often used in its salt form as chloroquine phosphate, which is also a white crystalline powder.

Comment on solubility

Solubility of 2-(dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)-4-quinolyl]ethanol

The solubility of 2-(dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)-4-quinolyl]ethanol can be described with some key considerations that influence its behavior in various solvents:

  • Polarity: The presence of the dibutylamino group typically enhances the solubility of the compound in polar solvents, especially alcohols and water.
  • Sterics: The bulky dibutyl chains may impede solubility to some extent in highly polar solvents due to steric hindrance. This could potentially limit interactions.
  • Chlorinated Phenyl Groups: The dichloro-substitutions in the phenyl ring can influence solubility, making the compound less soluble in non-polar solvents compared to polar solvents.
  • Hydrogen Bonding: The hydroxyl (-OH) group in the structure may partake in hydrogen bonding, thus enhancing solubility in water.

In summary, while 2-(dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)-4-quinolyl]ethanol is likely to show significant solubility in polar solvents due to its functional groups, the overall solubility profile would be a balance of its polar and non-polar characteristics. It can be stated that the solubility may vary significantly depending on the chosen solvent environment.

Interesting facts

Exploring 2-(Dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)-4-quinolyl]ethanol

2-(Dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)-4-quinolyl]ethanol is a fascinating compound that attracts attention in various fields, especially in medicinal chemistry and research into therapeutic agents. Here are some interesting facts:

  • Pharmaceutical Potential: This compound is being studied for its potential as a pharmaceutical agent, particularly in the field of oncology. Its complex structure may allow it to interact with biological targets in innovative ways.
  • Diverse Functional Groups: The presence of various functional groups, including the dibutylamino moiety and several chlorine substituents, imparts unique properties that can enhance its efficacy and bioavailability.
  • Analytical Importance: Researchers often utilize spectroscopic and chromatographic techniques to analyze this compound. Its unique structure helps in understanding interactions at a molecular level.
  • Structure-Activity Relationship (SAR): The compound's intricate arrangement allows for the exploration of SAR, providing insights into how structural modifications influence biological activity.
  • Environmental Considerations: With an increasing focus on environmental safety, studying the environmental impact and degradation of compounds like this one is essential, particularly in terms of its stability and toxicity.

As scientists delve deeper into the study of 2-(dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)-4-quinolyl]ethanol, the discoveries could lead to advancements in drug development and enhancement of therapeutic strategies in several diseases. The combination of its unique chemical structure and potential utility makes it a compound worth investigating further.

Synonyms
19160-62-4
WR-30090
WR 30090
3J38HG7ES7
NSC-112365
6,8-Dichloro-alpha-((dibutylamino)methyl)-2-(3,4-dichlorophenyl)-4-quinolinemethanol
6,8-Dichloro-2-(3',4'-dichlorophenyl)-alpha-(di-n-butylaminoethyl)-4-quinolinemethanol
4-Quinolinemethanol, 6,8-dichloro-alpha-((dibutylamino)methyl)-2-(3,4-dichlorophenyl)-
4-Quinolinemethanol, 6,8-dichloro-alpha-[(dibutylamino)methyl]-2-(3,4-dichlorophenyl)-
RefChem:195008
6,8-dichloro-2-(3',4'-dichlorophenyl)-alpha-(di-n-butylaminoethyl)-4-quinolinemethanol.HCl
2-(Dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)quinolin-4-yl]ethanol
alpha-(Dibutylaminomethyl)-6,8-dichloro-2-(3',4'-dichlorophenyl)-4-quinolinemethanol
2-(Dibutylamino)-1-(6,8-dichloro-2-(3,4-dichlorophenyl)quinolin-4-yl)ethanol
NSC 112365
UNII-3J38HG7ES7
CHEMBL1995683
SCHEMBL18343545
NSC112365
alpha-(Dibutylaminomethyl)-6,8-dichloro-2-(3,4-dichlorophenyl)-4-quinolinemethanol
NCI60_000272
DS-006412
2-(dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)-4-quinolyl]ethanol
.ALPHA.-(DIBUTYLAMINOMETHYL)-6,8-DICHLORO-2-(3,4-DICHLOROPHENYL)-4-QUINOLINEMETHANOL
4-QUINOLINEMETHANOL, 6,8-DICHLORO-.ALPHA.-((DIBUTYLAMINO)METHYL)-2-(3,4-DICHLOROPHENYL)-
6,8-DICHLORO-.ALPHA.-((DIBUTYLAMINO)METHYL)-2-(3,4-DICHLOROPHENYL)-4-QUINOLINEMETHANOL