Skip to main content

Dibucaine hydrochloride

ADVERTISEMENT
Identification
Molecular formula
C17H27ClFN2O2
CAS number
61-12-1
IUPAC name
2-(dibutylamino)ethyl 4-fluorobenzoate;hydrochloride
State
State

At room temperature, dibucaine hydrochloride is in a solid state. It manifests as fine crystalline particles which can be easily handled and stored under dry conditions to maintain its stability.

Melting point (Celsius)
99.00
Melting point (Kelvin)
372.15
Boiling point (Celsius)
215.00
Boiling point (Kelvin)
488.15
General information
Molecular weight
324.83g/mol
Molar mass
324.8340g/mol
Density
1.0660g/cm3
Appearence

Dibucaine hydrochloride appears as a white or almost white crystalline powder. It is highly soluble in water, giving solutions a clear and colorless appearance when dissolved.

Comment on solubility

Solubility of 2-(dibutylamino)ethyl 4-fluorobenzoate;hydrochloride

The solubility of 2-(dibutylamino)ethyl 4-fluorobenzoate; hydrochloride can be characterized by several factors, which are crucial for understanding its behavior in various solvents:

  • Solvent Type: This compound is generally more soluble in polar organic solvents due to its ionic characteristics from the hydrochloride form. Common solvents include:
    • Water
    • Methanol
    • Ethanol
    • Acetone
    • DMSO (Dimethyl sulfoxide)
  • Temperature Influence: Elevated temperatures can enhance solubility, as the increased kinetic energy helps overcome the intermolecular forces in the solid state. Thus, solubility may be observed to increase with temperature.
  • pH Level: As a hydrochloride salt, the solubility of this compound can be affected by pH levels, as the ionization state is sensitive to the surrounding acidity or basicity, altering its solubility characteristics.
  • Hydrogen Bonding: The presence of polar functional groups allows for potential hydrogen bonding with water molecules, further promoting solubility in aqueous solutions. This can lead to satisfactory dissolution rates.

In conclusion, the solubility profile of 2-(dibutylamino)ethyl 4-fluorobenzoate; hydrochloride is influenced by its ionic nature, the solvent used, temperature, pH levels, and hydrogen bonding capabilities. Understanding these factors is vital for applications in pharmaceuticals and chemical synthesis, ensuring effective use in various formulations.

Interesting facts

Interesting Facts about 2-(Dibutylamino)ethyl 4-fluorobenzoate; Hydrochloride

2-(Dibutylamino)ethyl 4-fluorobenzoate; hydrochloride is a fascinating compound with unique properties and applications in both research and industry. Here are some intriguing aspects:

  • Pharmaceutical Potential: This compound is an important intermediate in the synthesis of various pharmaceuticals, particularly in the field of drug design and development. The presence of the dibutylamino group enhances its biological activity, making it a potential candidate for drug formulation.
  • Fluorine's Role: The incorporation of fluorine atoms, such as in the 4-fluorobenzoate moiety, often imparts desirable characteristics like increased lipophilicity and stability to metabolic processes. This can lead to better bioavailability and pharmacokinetics of the resultant drugs.
  • Applications in Material Science: Beyond medicinal chemistry, 2-(dibutylamino)ethyl 4-fluorobenzoate; hydrochloride may also play a role in the development of advanced materials. Its ability to form strong intermolecular interactions can be harnessed in creating polymers with specific functionalities.
  • Structure-Activity Relationship Studies: Chemists often explore the structure-activity relationships (SAR) of this compound to optimize its therapeutic effects. By modifying the dibutylamino or the fluorobenzoate component, researchers can refine its efficacy and reduce potential side effects.
  • Environmental Considerations: As with many synthetic compounds, understanding the environmental impact is essential. Research into its degradation pathways and how it behaves in biological systems helps in assessing its safety and ecological footprint.

In summary, 2-(dibutylamino)ethyl 4-fluorobenzoate; hydrochloride is more than just a chemical entity; it represents intersections between chemistry, biology, and material science, offering a plethora of opportunities for discovering new applications and enhancing existing technologies.

Synonyms
495-65-8
Dibutylaminoethyl p-fluorobenzoate hydrochloride
Dibutylaminoethyl p-fluorobenzoate HCl
BENZOIC ACID, p-FLUORO-, DIBUTYLAMINOETHYL ESTER, HYDROCHLORIDE
DTXSID60197809