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Diphenhydramine

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Identification
Molecular formula
C17H21NO
CAS number
58-73-1
IUPAC name
[2-(diethylamino)-1-methyl-ethyl] 2,2-diphenylacetate
State
State

At room temperature, diphenhydramine is typically found in solid form, particularly as a crystalline powder or as formulated tablets and capsules for pharmaceutical uses. It may also be formulated in a liquid state for use in syrups.

Melting point (Celsius)
168.50
Melting point (Kelvin)
441.65
Boiling point (Celsius)
315.40
Boiling point (Kelvin)
588.55
General information
Molecular weight
255.34g/mol
Molar mass
255.3420g/mol
Density
1.1000g/cm3
Appearence

Diphenhydramine is commonly found as a white to off-white crystalline powder. It is often odorless and may have a distinct mild bitter taste. Under some formulations, it may also be available in a colored liquid form when compounded as a syrup.

Comment on solubility

Solubility of [2-(diethylamino)-1-methyl-ethyl] 2,2-diphenylacetate

The solubility of the compound [2-(diethylamino)-1-methyl-ethyl] 2,2-diphenylacetate is influenced by several factors related to its chemical structure and interactions with solvents.

Factors Affecting Solubility

  • Polarity: This compound contains both polar and nonpolar regions, which can lead to its solubility in a variety of solvents.
  • Hydrogen Bonding: The presence of the diethylamino group allows for potential hydrogen bonding, enhancing solubility in polar solvents such as water.
  • Solvent Compatibility: The large diphenylacetate moiety suggests a higher solubility in organic solvents like ethanol, chloroform, or acetone.

As a rule of thumb, compounds tend to be soluble in solvents that match their polarity. Thus, while [2-(diethylamino)-1-methyl-ethyl] 2,2-diphenylacetate may show good solubility in organic solvents, its solubility in water could be limited despite some capacity due to hydrogen bonding.

General Observations

When assessing the solubility of this compound, consider the following:

  1. Dynamic interactions between solute and solvent.
  2. Temperature effects on solubility.
  3. The presence of other solutes that might influence solubility via common ion effect or complexation.

In summary, the solubility of [2-(diethylamino)-1-methyl-ethyl] 2,2-diphenylacetate is anticipated to be favorable in a range of organic solvents while being limited in polar solvents like water. Understanding these aspects helps in the practical utilization of the compound in various chemical applications.

Interesting facts

Interesting Facts About [2-(diethylamino)-1-methyl-ethyl] 2,2-diphenylacetate

[2-(diethylamino)-1-methyl-ethyl] 2,2-diphenylacetate is a fascinating compound with a diverse range of applications and properties that intrigue both chemists and industry professionals. Here are some points that highlight its significance:

  • Pharmaceutical Relevance: This compound is often explored in the context of drug development, particularly for its potential in treating various medical conditions. Its unique structure allows for interactions with biological systems that can be pivotal for therapeutical efficacy.
  • Functional Groups: The presence of the diethylamino group contributes to its basicity, which in turn influences its solubility and reactivity. The dual phenyl groups offer steric hindrance that can affect how the compound interacts with other molecules.
  • Design Versatility: The structural characteristics of this compound make it an interesting candidate for the design of new materials in organic synthesis. It serves as a scaffold for creating more complex molecules.
  • Research Applications: Chemists frequently investigate compounds like this for their behavior in various chemical reactions and their roles in catalysis or materials science.
  • Quotable Insight: As with many complex organic molecules, understanding their reactivity is key. A noted organic chemist once said, “The beauty of chemistry lies in how diverse structures can lead to profound reactivity.”

Overall, [2-(diethylamino)-1-methyl-ethyl] 2,2-diphenylacetate stands out not only for its intricate construction but also for its potential applications, making it a topic worthy of exploration and study in the field of chemistry.

Synonyms
1-(diethylamino)propan-2-yl diphenylacetate
2-(diethylamino)-1-methylethyl diphenylacetate hydrochloride
3213-44-3
ALBB-035780
STK182807
AKOS003658724
AKOS022078086