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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
2-(diethylamino)-N-(2,4,6-trimethylphenyl)acetamide
State
State

At room temperature, lidocaine is typically a solid powder. It may appear as crystalline or amorphous, depending on the specific formulation. In certain applications, it may also be distributed in liquid form, such as in topical anesthetic creams or injectable solutions.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
180.00
Boiling point (Kelvin)
453.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3370g/mol
Density
1.0260g/cm3
Appearence

Lidocaine appears as a white or slightly yellow crystalline powder. It is usually odorless but may have a slight characteristic odor and has a slightly bitter taste. Lidocaine is typically available in a variety of formulations, including powders and injectable solutions. It is soluble in water and very soluble in alcohol and chloroform.

Comment on solubility

Solubility of 2-(diethylamino)-N-(2,4,6-trimethylphenyl)acetamide

The solubility of 2-(diethylamino)-N-(2,4,6-trimethylphenyl)acetamide, a compound known for its unique structure, can vary significantly based on several factors. Understanding its solubility behavior is crucial for applications in various fields such as pharmaceuticals and chemical synthesis.

Factors Influencing Solubility

  • Polarity: The presence of the diethylamino group suggests that the compound is relatively polar, which may enhance its solubility in polar solvents such as water.
  • Hydrophobicity: The bulky 2,4,6-trimethylphenyl group may introduce hydrophobic characteristics that could limit solubility in aqueous solutions.
  • Temperature: Like many compounds, solubility may increase with temperature, allowing for better dissolution in solvents.
  • pH of the Solution: The acid-base properties of amino groups can play a significant role in solubility, affecting its ionization state in various pH environments.

In summary, one might say, "The interaction of structural features with solvent properties ultimately determines the solubility." Therefore, predicting the exact solubility in various solvents requires careful consideration of these factors. Further experimental studies would greatly benefit the understanding of this compound’s solubility profile.

Interesting facts

Interesting Facts about 2-(Diethylamino)-N-(2,4,6-trimethylphenyl)acetamide

The compound 2-(diethylamino)-N-(2,4,6-trimethylphenyl)acetamide, often abbreviated for convenience, is a fascinating member of the amide family. This specific compound showcases interesting chemical properties and potential applications.

Chemical Characteristics

  • Amide Functionality: As an amide, this compound bears important implications in medicinal chemistry, often acting as a building block in drug design.
  • Substituent Influence: The presence of the diethylamino group significantly enhances its solubility and reactivity, attributes that are critical in pharmaceutical contexts.
  • Aromatic Stability: The 2,4,6-trimethylphenyl moiety contributes to the electron-donating effects, stabilizing the overall structure and influencing its interactions with biological targets.

Applications and Uses

  • Pharmaceutical Intermediates: This compound can serve as an intermediate in the synthesis of various pharmaceutical agents.
  • Research Potential: Due to its unique structure, it holds potential for research in areas like neurochemistry and drug formulation.
  • SAR Studies: It is often included in Structure-Activity Relationship (SAR) studies, where slight modifications can lead to significant changes in biological activity.

In the words of chemists, "The beauty of chemistry lies in the transformation potential." This compound exemplifies that beauty, offering a canvas for modifications and explorations in both research and industrial applications. Its unique attributes pave the way for enhanced drug development and a deeper understanding of molecular interactions in biological systems.


Synonyms
Trimecaine
616-68-2
Mesidicain
Mesidicaine
Trimecain
Justecaina
Diethylglycinemesidide
Trimecaine [INN]
Trimecaina
2-(Diethylamino)-N-(2,4,6-trimethylphenyl)acetamide
Trimecainum
Mesdicain
Trimecainum [INN-Latin]
Trimecaina [INN-Spanish]
Mesocain
Mesokain
Trimekain
Acetamide, 2-(diethylamino)-N-(2,4,6-trimethylphenyl)-
EINECS 210-487-3
UNII-IN1233R0JO
Trimecaine (INN)
2-(Diethylamino)-2',4',6'-trimethylacetanilide
BRN 2697351
IN1233R0JO
Mesocain (Salt/Mix)
Mesocaine (Salt/Mix)
TRIMECAINE [MI]
ACETANILIDE, 2-(DIETHYLAMINO)-2',4',6'-TRIMETHYL-
TRIMECAINE [WHO-DD]
DTXSID6048410
3-12-00-02712 (Beilstein Handbook Reference)
.omega.-Diethylaminoacetylaminomesitylene
Mesocain (TN)
Trimecainum (INN-Latin)
Trimecaina (INN-Spanish)
N-(Diethylaminoacetyl)-2,4,6-trimethylaniline
DTXCID4028383
omega-Diethylaminoacetylaminomesitylene
Acetamide, 2-(diethylamino)-N-(2,4,6-trimethylphenyl)-(9CI)
210-487-3
gozbhbfuqhmkqb-uhfffaoysa-n
2-(Diethylamino)-N-mesitylacetamide
Acetamide,2-(diethylamino)-N-(2,4,6-trimethylphenyl)-
NCGC00065440-02
CBMicro_019206
2-Diethylamino-2',4',6'-trimethylacetanilide
SCHEMBL24692
CHEMBL1618597
CHEBI:135013
BCP09485
STK735536
AKOS001589944
2-(Diethylamino)-N-mesitylacetamide #
NS00006371
N~2~,N~2~-diethyl-N~1~-mesitylglycinamide
2-(DIETHYLAMINO)-N~1~-MESITYLACETAMIDE
D08640
Q3048749
N~2~,N~2~-diethyl-N-(2,4,6-trimethylphenyl)glycinamide