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Lidocaine

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Identification
Molecular formula
C14H22FN2O
CAS number
137-58-6
IUPAC name
2-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)acetamide
State
State

At room temperature, Lidocaine is typically a solid. In its pure form, it presents as a crystalline powder, and it is stable under normal temperatures and pressures. It is usually administered in a dissolved state in medical applications.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.20
Boiling point (Celsius)
350.80
Boiling point (Kelvin)
623.90
General information
Molecular weight
234.34g/mol
Molar mass
234.3390g/mol
Density
1.0260g/cm3
Appearence

Lidocaine typically presents as a white, crystalline powder. It is odorless and may have a slightly bitter taste when dissolved in water. The compound is often used in its hydrochloride form for medical applications, which also appears as a white powder.

Comment on solubility

Solubility of 2-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)acetamide

The solubility of 2-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)acetamide is influenced by several factors, making it a compound of interest in various applications.

  • Polarity: The presence of the diethylamino group contributes to the compound's polarity, which can enhance its solubility in polar solvents such as water.
  • Hydrophobic Regions: The aromatic ring containing the fluoro substituent adds a hydrophobic character, which may reduce solubility in polar solvents but increase it in organic solvents.
  • Hydrogen Bonding: The ability of the amide functional group to engage in hydrogen bonding plays a significant role in the solubility in various solvents.

Overall, the solubility of 2-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)acetamide can vary dramatically, making it essential to explore compatibility with different solvent systems during practical applications. It's worthwhile to note that solubility tests in both polar and non-polar environments can provide deeper insight:

  1. Solubility in water should be verified due to its polar nature.
  2. Investigate solubility in organic solvents like ethanol or acetone to assess performance in drug formulation.
  3. Factors such as temperature and pH can further affect solubility, making systematic testing crucial.

In conclusion, the solubility characteristics of 2-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)acetamide present exciting opportunities for its use in pharmaceuticals and other industries, making detailed experimental analyses essential.

Interesting facts

Interesting Facts about 2-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)acetamide

This compound is a fascinating example of a synthetic organic chemical that showcases the intersection of medicinal chemistry and material science. Here are some insightful points about this compound:

  • Pharmaceutical Potential: The intriguing structure of this compound suggests it may be significant in the development of pharmaceuticals, particularly in the fields of analgesics and anti-inflammatory agents. Its unique functional groups contribute to its potential pharmacological activities.
  • Structural Diversity: The presence of both a diethylamino group and a fluoro-substituted phenyl ring highlights the structural diversity achievable in organic synthesis, enabling researchers to explore a wide range of biological effects.
  • Fluorine's Influence: The fluorine atom in the molecule is known for its ability to enhance metabolic stability and lipophilicity, providing a strategic advantage in drug design by potentially improving bioavailability.
  • Research Insights: Studies on compounds like this one often involve exploring their interaction with biological targets, which can lead to new understanding in drug mechanisms and therapeutic applications.
  • Green Chemistry Considerations: The synthesis of such compounds also invites discussions around green chemistry practices, encouraging processes that minimize environmental impact and increase efficiency.

In sum, 2-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)acetamide is more than just a chemical formula; it represents a broader dialogue about innovation in chemical research and its potential applications in enhancing human health and wellbeing.

Synonyms
BRN 2697131
ACETANILIDE, 2-(DIETHYLAMINO)-5'-ETHYL-2'-FLUORO-
2-(Diethylamino)-5'-ethyl-2'-fluoroacetanilide
787-99-5
alpha-Diaethylamino-3-aethyl-6-fluor-acetanilid [German]
DTXSID80229252
alpha-Diaethylamino-3-aethyl-6-fluor-acetanilid
DTXCID00151743