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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
2-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)acetamide
State
State

In its pure form, lidocaine is a solid at room temperature. It is commonly encountered in a liquid form when used in medical applications as a local anesthetic.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.00
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.00
General information
Molecular weight
234.34g/mol
Molar mass
234.3390g/mol
Density
1.0260g/cm3
Appearence

Lidocaine appears as a white crystalline powder. It is often available in solutions for medical use, where it appears clear and colorless.

Comment on solubility

Solubility of 2-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)acetamide

The solubility of 2-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)acetamide can be characterized by several important factors:

  • Polarity: The compound contains both polar and nonpolar groups, which can affect its overall solubility in various solvents.
  • Solvent Interaction: It tends to be more soluble in organic solvents such as ethanol and dichloromethane due to the presence of the diethylamino moiety.
  • Temperature Dependence: Increased temperatures generally enhance the solubility of organic compounds, which may be relevant for this amide.
  • Functional Groups: The presence of the acetamide functional group may allow for hydrogen bonding, which could enhance solubility in polar solvents, particularly when functionalities are available for interaction.

It's essential to consider that the solubility can vary widely based on the environmental conditions and the specific solvent used. As a general guideline, while the compound is likely sparingly soluble in water, its solubility in organic solvents is expected to be significantly higher. As always, practical solubility should be confirmed through experimentation to achieve reliable results in any application.

Interesting facts

Interesting Facts about 2-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)acetamide

This unique compound, commonly referred to in medicinal chemistry, showcases the fascinating interplay between organic structures and biological activity. Here are some key aspects that highlight its significance:

  • Pharmacological Potential: This compound belongs to the class of acetamides, which are known for their roles in developing various pharmaceuticals. Specifically, its structure suggests potential applications in analgesics or anesthetics, making it a topic of interest in pharmacological studies.
  • Structural Diversity: The diethylamino group contributes to its unique properties. The presence of different alkyl groups can significantly influence the compound's lipophilicity and overall biological behavior, which is crucial in drug design.
  • Interactions with Receptors: The aromatic substituent (5-ethyl-2-methyl-phenyl group) can engage in π-π stacking and hydrophobic interactions, which may enhance the compound's affinity toward specific biological targets, potentially leading to increased efficacy.
  • Research Relevance: Many researchers are currently exploring derivatives of such compounds in search of novel therapies for pain management, demonstrating the ongoing relevance of this structure in modern medicinal chemistry.
  • Synergistic Effects: Compounds like this often serve as lead compounds, providing a template for modifications that can enhance efficacy or reduce side effects when combined with other pharmacophores.

In conclusion, the intricate design of 2-(diethylamino)-N-(5-ethyl-2-methyl-phenyl)acetamide underscores the remarkable complexity of chemical compounds and their potential impact on therapeutic avenues. As we continue to uncover the mechanisms of such substances, the advancements in pharmaceutical science are boundless.

Synonyms
672-10-6
BRN 2696100
Acetamide, 2-(diethylamino)-N-(5-ethyl-2-methylphenyl)-
o-ACETOTOLUIDIDE, 2-(DIETHYLAMINO)-5'-ETHYL-
2-(Diethylamino)-5'-ethyl-2'-methylacetanilide
alpha-Diaethylamino-3-aethyl-6-methyl-acetanilid [German]
DTXSID20217476
alpha-Diaethylamino-3-aethyl-6-methyl-acetanilid
DTXCID20139967