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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
2-(diethylamino)-N-phenyl-acetamide
State
State

At room temperature, Lidocaine is usually in a solid state.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3370g/mol
Density
1.0300g/cm3
Appearence

Lidocaine is typically encountered as a white crystalline powder.

Comment on solubility

Solubility of 2-(diethylamino)-N-phenyl-acetamide

The solubility of 2-(diethylamino)-N-phenyl-acetamide can be influenced by several factors, including temperature, pH, and the presence of other solutes. Generally, compounds such as this one exhibit varying solubility profiles depending on their molecular structure. Here are some key points regarding its solubility:

  • Polar and Nonpolar Interactions: The compound contains both polar functional groups (amino) and nonpolar parts (phenyl group), which may lead to moderate solubility in polar solvents.
  • Solvent Type: It is likely to dissolve more readily in organic solvents such as alcohols or chloroform, compared to water, due to its hydrophobic characteristics.
  • Effect of Temperature: As temperature increases, solubility in organic solvents typically increases, which can enhance the efficacy of the compound in various applications.
  • pH Dependence: Changes in pH can also affect the ionization of the amino group, thus impacting solubility. At certain pH levels, higher solubility may be observed due to increased ionization.

In conclusion, while specific solubility data for 2-(diethylamino)-N-phenyl-acetamide may require empirical testing, understanding its structural characteristics can provide insights into its solubility behavior. As with many chemical compounds, the phrase “like dissolves like” often holds true, emphasizing the importance of solvent choice when considering solubility.

Interesting facts

Interesting Facts about 2-(diethylamino)-N-phenyl-acetamide

2-(diethylamino)-N-phenyl-acetamide, commonly referred to in research as a member of the amide family, stands out for several fascinating reasons! Here are some insights:

  • Biological Significance: This compound is known for its activity in medicinal chemistry, particularly as an analgesic and anesthetic agent. Its diethylamino group provides a unique interaction with biological receptors, making it a subject of interest in pharmacology.
  • Synthetic Versatility: The ability to modify the amide function and explore different substituents opens a pathway for researchers to develop derivatives that could enhance therapeutic effects or reduce side effects.
  • Research Applications: Scientists often delve into this compound to study its influence on pain pathways. Its structure allows for various experimental approaches to understanding receptor interactions.
  • Structure-Activity Relationship (SAR): The compound serves as an excellent candidate for exploring SAR studies. Alterations to the diethylamino or phenyl groups can yield significant differences in biological activity.

As a chemist or a chemistry student, it is intriguing to observe how a single compound can possess such a wealth of potential applications. The field of medicinal chemistry is constantly evolving, and compounds like 2-(diethylamino)-N-phenyl-acetamide add valuable contributions to the ongoing quest for effective pharmaceuticals.

This compound demonstrates the fascinating interplay between structure and function in organic chemistry, prompting researchers to ask deeper questions about chemical behavior and biological mechanisms. As we continue to unwrap the complexities of compounds like this, it is essential to appreciate their role in advancing medical science.

Synonyms
3213-15-8
2-(diethylamino)-N-phenylacetamide
die-thylaminoacetanilid
LIDOCAINE,DI-DEMETHYL
SCHEMBL8623174
DTXSID50876934
AKOS002844364