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Lidocaine

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Identification
Molecular formula
C14H22N2O2
CAS number
137-58-6
IUPAC name
2-(diethylamino)ethyl 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoate
State
State

At room temperature, lidocaine is a solid. It is stable under normal conditions and is commonly used in its powdered form or in solutions for medical applications.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
350.15
Boiling point (Kelvin)
623.30
General information
Molecular weight
234.34g/mol
Molar mass
234.3360g/mol
Density
1.2390g/cm3
Appearence

Lidocaine typically appears as a white or slightly yellow crystalline powder. It is known for its slightly bitter taste and absence of a discernable odor.

Comment on solubility

Solubility of 2-(diethylamino)ethyl 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoate

The solubility of 2-(diethylamino)ethyl 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoate can pose interesting challenges due to its molecular structure. This compound features complex functional groups that influence how it interacts with solvents. Generally, the key factors affecting solubility include:

  • Polarity: The presence of the diethylamino and benzoate groups gives this compound both hydrophilic and hydrophobic characteristics, which can lead to varied solubility in different solvents.
  • Temperature: As with many organic compounds, solubility can increase with temperature. Thus, examining the solubility at different temperatures can provide valuable insight.
  • Solvent Choice: This compound is likely more soluble in organic solvents like ethanol or dimethyl sulfoxide (DMSO) rather than in polar solvents such as water, due to its larger hydrophobic regions.

In practice, researchers often find that:

  • Strong organic solvents can dissolve the compound effectively.
  • Water solubility may be limited, necessitating the use of cosolvents or surfactants to increase dispersion.

Overall, understanding the solubility of this compound not only aids in its application in various fields but also opens the door to effective formulation strategies by tailoring the solvent environment.

Interesting facts

Interesting Facts about 2-(diethylamino)ethyl 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoate

This compound, often abbreviated for convenience, is a fascinating example of a synthetic organic compound that belongs to the class of medications known as quinazolines. Quinazolines are notable in medicinal chemistry due to their diverse biological activities, and this specific derivative features a unique structure that incorporates both a diethylamino group and a benzoate moiety.

Key Features and Applications:

  • Diverse Applications: Compounds similar to this one are frequently studied for their potential applications in treating various diseases, including cancer and infections.
  • Unique Structural Attributes: The presence of the 2-methyl-4-oxo-quinazolin-3-yl core contributes to its unique pharmacological properties, enhancing its ability to interact with biological targets.
  • Synthetic Utility: The synthesis of such compounds provides an excellent platform for exploring structure-activity relationships, which is vital for drug development.

Moreover, scientists are continually researching how modifications to the core structure can lead to enhanced efficacy and selectivity. As computational chemistry evolves, understanding how this compound interacts at the molecular level becomes increasingly feasible, opening doors to new therapeutic innovations.

Research Trends:

  • Biological Activity Studies: Ongoing research seeks to evaluate how modifications to the quinazoline framework can improve biological activity against specific cancer cell lines.
  • Analytical Techniques: Techniques such as NMR spectroscopy and mass spectrometry are pivotal in understanding the compound’s structure and verifying its purity during the synthesis process.
  • Potential Side Effects: Like many synthetic compounds, understanding the side effects and mechanisms of action is crucial for its development into a viable therapeutic agent.

In conclusion, 2-(diethylamino)ethyl 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoate exemplifies the intricate blend of chemistry and biology, showcasing the potential that such complex molecules hold for advancing medical science. As research continues, its journey could pave the way for significant breakthroughs in pharmaceuticals.