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Flecainide

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Identification
Molecular formula
C17H21ClFNO3
CAS number
54143-58-7
IUPAC name
2-(diethylamino)ethyl 2-(4-fluorophenoxy)acetate;hydrochloride
State
State
It is found in a solid state in its pure form at room temperature.
Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
413.90g/mol
Molar mass
413.8980g/mol
Density
1.2820g/cm3
Appearence

Flecainide hydrochloride is typically a white to almost white crystalline powder. It is odorless or has a faintly perceptible odor.

Comment on solubility

Solubility of 2-(diethylamino)ethyl 2-(4-fluorophenoxy)acetate; hydrochloride

In considering the solubility of the compound 2-(diethylamino)ethyl 2-(4-fluorophenoxy)acetate; hydrochloride, several factors come into play that highlight its behavior in different solvents.

General Solubility Characteristics

This compound is a hydrochloride salt, which generally indicates higher solubility in polar solvents. The presence of the diethylamino group contributes to its solubility in aqueous environments due to the ability to form hydrogen bonds. Here are some key points regarding its solubility:

  • Aqueous Solubility: The hydrochloride form typically dissolves well in water, owing to the ionic nature of the salt.
  • Organic Solvents: It may exhibit varied solubility in organic solvents. Polar aprotic solvents, like dimethyl sulfoxide (DMSO) or acetonitrile, could enhance solubility due to their ability to solvate ionic species.
  • Temperature Dependence: Solubility often increases with temperature; thus, heating the solution could potentially increase the dissolution of this compound.

Factors Affecting Solubility

The solubility can also be influenced by:

  • The pH of the solution: Hydrochloride salts tend to be stable and soluble in acidic conditions.
  • Interactions with other solutes: The presence of certain ions or molecules could either enhance or inhibit solubility through competitive binding or solvation effects.

In summary, 2-(diethylamino)ethyl 2-(4-fluorophenoxy)acetate; hydrochloride is expected to have a favorable solubility profile in polar solvents, especially water, while potentially demonstrating variable behavior in organic media.
Understanding its solubility is crucial for applications in pharmacology and materials science.

Interesting facts

Interesting Facts about 2-(diethylamino)ethyl 2-(4-fluorophenoxy)acetate;hydrochloride

The compound 2-(diethylamino)ethyl 2-(4-fluorophenoxy)acetate; hydrochloride is a fascinating entry in the field of organic chemistry, particularly known for its complex structure and potential applications. Here are some intriguing insights:

  • Pharmaceutical Relevance: This compound, due to its unique chemical structure, is often explored in drug development, potentially serving as a lead compound for new therapeutic agents.
  • Functional Groups: The presence of the diethylamino and fluorophenoxy functional groups highlights the diversity of interactions this molecule can engage in, which may influence its behavior in biological systems.
  • Fluorine's Influence: The incorporation of a fluorine atom generally enhances the lipophilicity and metabolic stability of organic compounds, making this derivative particularly interesting for medicinal chemistry.
  • Biological Activity: Compounds similar to this one are often evaluated for their effects on neurotransmission and have been researched for their potential as analgesics or neuroprotective agents.
  • Synthetic Versatility: The synthesis of this compound involves interesting methodologies that can serve as a teaching moment for students in organic chemistry labs, showcasing techniques from functional group transformations to purification steps.

This compound exemplifies how small modifications in chemical structure can significantly alter biological activity, making it a subject worthy of further study in both academic and industrial research.

In summary, 2-(diethylamino)ethyl 2-(4-fluorophenoxy)acetate; hydrochloride not only displays chemical elegance but also holds promise in the realms of pharmacology and synthesis, embodying the spirit of discovery inherent in the chemical sciences.

Synonyms
351-69-9
(p-Fluorophenoxy)acetic acid 2-(diethylamino)ethyl ester hydrochloride
2-diethylaminoethyl 2-(4-fluorophenoxy)acetate hydrochloride
2-(diethylamino)ethyl 2-(4-fluorophenoxy)acetate;hydrochloride
DTXSID60956534
CHDXBHHROSPLRM-UHFFFAOYSA-N
ACETIC ACID, (p-FLUOROPHENOXY)-, 2-(DIETHYLAMINO)ETHYL ESTER, HYDROCHLORIDE
SR-01000254168
SR-01000254168-1
2-(Diethylamino)ethyl (4-fluorophenoxy)acetate--hydrogen chloride (1/1)