Skip to main content

Loperamide

ADVERTISEMENT
Identification
Molecular formula
C29H33ClN2O2
CAS number
34552-83-5
IUPAC name
2-(diethylamino)ethyl 2-ethoxy-2,2-diphenyl-acetate
State
State

At room temperature, loperamide is in a solid state.

Melting point (Celsius)
209.00
Melting point (Kelvin)
482.00
Boiling point (Celsius)
496.10
Boiling point (Kelvin)
769.20
General information
Molecular weight
477.59g/mol
Molar mass
477.5850g/mol
Density
1.1140g/cm3
Appearence

Loperamide typically appears as a white to slightly off-white crystalline powder.

Comment on solubility

Solubility of 2-(diethylamino)ethyl 2-ethoxy-2,2-diphenyl-acetate

The compound 2-(diethylamino)ethyl 2-ethoxy-2,2-diphenyl-acetate, often referred to in its full chemical structure, exhibits interesting solubility characteristics that are influenced by its unique chemical constituents. The presence of both hydrophobic (phenyl groups) and hydrophilic (amino and ether groups) parts in the molecule leads to variability in its solubility depending on the solvent used.

Solubility in Different Solvents

  • Polar solvents: Generally, compounds with amino groups show some degree of solubility in polar solvents such as water and alcohols, though the solubility may not be very high due to the bulky diphenyl structure.
  • Non-polar solvents: The presence of two phenyl rings prominently increases solubility in non-polar solvents like hexane or toluene, where the compound's hydrophobic nature is effectively accommodated.
  • Mixed solvents: The solubility in mixed solvents (e.g., ethanol-water mixtures) largely depends on the ratio of polar to non-polar components, often enhancing the solubility compared to pure solvents.

As a general note, solubility can be highly dependent on temperature, and increasing temperature often leads to higher solubility for many organic compounds. It's also essential to consider that solvent polarity plays a critical role; using solvents with similar polarity to the compound can result in better solubility results.

In conclusion, understanding the solubility profile of 2-(diethylamino)ethyl 2-ethoxy-2,2-diphenyl-acetate is vital for applications in chemical synthesis and pharmacology, making it crucial to select the proper solvent for effective results. As the old adage goes, "like dissolves like," which is a guiding principle for predicting solubility behavior in various conditions.

Interesting facts

Interesting Facts about 2-(Diethylamino)ethyl 2-ethoxy-2,2-diphenyl-acetate

2-(Diethylamino)ethyl 2-ethoxy-2,2-diphenyl-acetate, also known for its various applications in medicinal chemistry, presents a fascinating profile worth exploring. Here are several engaging aspects of this intriguing compound:

  • Pharmacological Potential: This compound can serve as a scaffold in drug design, due to the presence of both the diethylamino and diphenyl groups, which may enhance its pharmacokinetic properties.
  • Mechanism of Action: Research suggests that derivatives of this compound might interact with neurotransmitter systems, potentially leading to psychoactive effects, grounding its relevance in neuropharmacology.
  • Synthesis Techniques: The synthesis of this compound often involves a combination of amine alkylation and esterification reactions, presenting an interesting challenge for organic chemists.
  • Structure-Activity Relationship (SAR): Understanding the SAR is critical for determining the biological activity and improving the efficacy of similar compounds. The variations in substituents can lead to significant changes in activity.
  • Versatile Applications: Beyond medicinal uses, compounds similar to this one have been explored in materials science and pesticides, showcasing their versatility and importance in various fields.

In conclusion, 2-(diethylamino)ethyl 2-ethoxy-2,2-diphenyl-acetate is more than just a chemical formula; its complex structure offers invaluable insights into potential therapeutic and industrial applications, reflecting the beauty and utility of organic chemistry.