Skip to main content

Lidocaine

ADVERTISEMENT
Identification
Molecular formula
C17H27NO2
CAS number
137-58-6
IUPAC name
2-(diethylamino)ethyl 2,2-diphenylpentanoate
State
State
Lidocaine is typically found in its solid form as a powder at room temperature. When used in medical applications, it is often formulated as an aqueous solution or suspension.
Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
180.00
Boiling point (Kelvin)
453.15
General information
Molecular weight
324.45g/mol
Molar mass
324.4510g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is typically available as a white crystalline powder. It is odorless and has a slightly bitter taste. In solution, it is usually clear and colorless.

Comment on solubility

Solubility of 2-(diethylamino)ethyl 2,2-diphenylpentanoate

The solubility characteristics of 2-(diethylamino)ethyl 2,2-diphenylpentanoate (C17H27NO2) are intriguing due to its complex structure. This compound features both hydrophobic and hydrophilic components, which influence its solubility in various solvents.

Factors Affecting Solubility:

  • Polarity: The presence of the diethylamino group contributes to certain polar characteristics, enhancing solubility in polar solvents to some extent.
  • Hydrophobic Interactions: The bulky diphenyl and pentanoate moieties increase the hydrophobic nature, making it less soluble in water.
  • Solvent Choice: Common solvents such as ethanol or chloroform may work well for dissolving this compound due to their ability to interact with both polar and non-polar regions.

As a general observation, it is essential to consider that compounds with significant non-polar characteristics, like 2-(diethylamino)ethyl 2,2-diphenylpentanoate, tend to be poorly soluble in water, while they may exhibit higher solubilities in organic solvents. Therefore, when evaluating solubility, the end application and solvent should always be taken into account.


Interesting facts

Exploring 2-(diethylamino)ethyl 2,2-diphenylpentanoate

2-(diethylamino)ethyl 2,2-diphenylpentanoate, often referred to in scientific literature as a compound with significant relevance in medicinal chemistry, showcases intriguing properties and applications that capture the interest of chemists. Here are some engaging aspects of this compound:

  • Structural Diversity: The molecular architecture of 2-(diethylamino)ethyl 2,2-diphenylpentanoate features a unique combination of functionalities, including a diethylamino group and a branched pentanoate chain, which contribute to its potential bioactivity.
  • Pharmacological Potential: Compounds like 2-(diethylamino)ethyl 2,2-diphenylpentanoate are often investigated for their role in drug design, particularly for their effects on the central nervous system. The presence of the amino group enhances its capability to cross the blood-brain barrier, positioning it as a candidate for developing therapeutics.
  • Synthetic Methodology: The synthesis of this compound can be achieved through several organic reactions, demonstrating students' skills in multi-step synthesis. Understanding these processes boosts practical laboratory experience and theoretical knowledge.
  • Research Implications: Scientists are continuously studying this class of compounds for antidepressant and anesthetic properties, which are crucial in medicine. The exploration of analogs can yield substances with even refined characteristics and potency.

As we delve into the world of organic chemistry, compounds such as 2-(diethylamino)ethyl 2,2-diphenylpentanoate remind us of the profound connection between molecular structure and biological activity, highlighting the endless possibilities that await discovery in chemical research.

Synonyms
proadifen
302-33-0
Ethyl aprofen
Proadifen [INN]
Proadifene
Proadifeno
BCTB
Proadifenum
Proadifene [INN-French]
Proadifenum [INN-Latin]
Proadifeno [INN-Spanish]
2-(Diethylamino)ethyl 2,2-diphenylpentanoate
CCRIS 7248
HL 8727
2-Diethylaminoethyl propyldiphenylacetate
2-Diethylaminoethyl-2,2-diphenylvalerate
AV 54315
UNII-A510CA4CBT
ACETIC ACID, PROPYLDIPHENYL-, 2-(DIETHYLAMINO)ETHYL ESTER
A510CA4CBT
BRN 2478573
AI3-22951
Benzeneacetic acid, .alpha.-phenyl-.alpha.-propyl-, 2-(diethylamino)ethyl ester
2,2-Diphenylpentansaeure-2-diethylaminoethylester
5171 RP (Salt/Mix)
RP 5171 (Salt/Mix)
SKF-525-A (Salt/Mix)
CHEMBL282567
Valeric acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester
NSC-39690 (Salt/Mix)
DTXSID2048452
Proadifen hydrochloride (Salt/Mix)
4-09-00-02566 (Beilstein Handbook Reference)
Proadifene (INN-French)
Proadifenum (INN-Latin)
Proadifeno (INN-Spanish)
Benzeneacetic acid, alpha-phenyl-alpha-propyl-, 2-(diethylamino)ethyl ester
2-(DIETHYLAMINO)ETHYL-2,2-DIPHENYLVALERATE
2,2-Diphenylvaleric acid 2-(diethylamino)ethyl ester
NSC39690
NSC170997
CAS-62-68-0
2-(Diethylamino)ethyl 2,2-diphenylvalerate hydrochloride
2-Diethylaminoethyl .alpha.,.alpha.-diphenyl valerate hydrochloride
Spectrum_001487
2-diethylaminoethyl 2,2-diphenylpentanoate
Prestwick0_000778
Prestwick1_000778
Prestwick2_000778
Prestwick3_000778
Spectrum2_000924
Spectrum3_001172
Spectrum4_000328
Spectrum5_001164
Lopac-P-1061
Lopac0_000906
BSPBio_000856
BSPBio_002783
KBioGR_000675
KBioSS_001967
DivK1c_000737
SCHEMBL122630
SPBio_000828
SPBio_002795
BPBio1_000942
DTXCID8028426
CHEBI:92811
KBio1_000737
KBio2_001967
KBio2_004535
KBio2_007103
KBio3_002283
NINDS_000737
BDBM50017716
HSCI1_000231
STK049476
AKOS003658590
Acetate, Diethylaminoethyldiphenylpropyl
CCG-204988
SDCCGSBI-0050881.P004
IDI1_000737
NCGC00015799-01
NCGC00015799-02
NCGC00015799-03
NCGC00015799-04
NCGC00015799-11
NCGC00162290-01
SBI-0050881.P003
AB00053629
NS00015025
2-(Diethylamino)ethyl 2,2-diphenylpentanoate #
AB00053629_10
AB00053629_11
Q7246819
2-Benzhydryl-pentanoic acid 2-diethylamino-ethyl ester
BRD-K46317332-003-05-3
BRD-K46317332-003-06-1
BRD-K46317332-003-10-3
BRD-K46317332-003-16-0
BRD-K46317332-003-17-8
BRD-K46317332-003-18-6
2,2-Diphenyl-pentanoic acid 2-diethylamino-ethyl ester
Valeric acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester (8CI)
Benzeneacetic acid, alpha-phenyl-alpha-propyl-, 2-(diethylamino)ethyl ester (9CI)