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Fentanyl

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Identification
Molecular formula
C22H28N2O1
CAS number
437-38-7
IUPAC name
2-(diethylamino)ethyl 3-(2-furyl)-2-(1-naphthyl)propanoate
State
State

At room temperature, fentanyl is typically encountered as a solid; however, it is also formulated into transdermal and injectable forms for medical use. Its hydrochloride form is highly soluble in water.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.65
Boiling point (Celsius)
55.00
Boiling point (Kelvin)
328.15
General information
Molecular weight
336.48g/mol
Molar mass
336.4690g/mol
Density
1.3150g/cm3
Appearence

Fentanyl appears as a white to off-white powder. It is often encountered in its hydrochloride salt form, which is a white crystalline substance.

Comment on solubility

Solubility of 2-(diethylamino)ethyl 3-(2-furyl)-2-(1-naphthyl)propanoate

The solubility of 2-(diethylamino)ethyl 3-(2-furyl)-2-(1-naphthyl)propanoate can be quite intriguing due to its unique structure. When examining the solubility characteristics, several factors come into play:

  • Polar vs. Non-Polar: This compound features both polar (the diethylamino group) and non-polar (the naphthyl group) characteristics, suggesting that it may exhibit moderate solubility in polar solvents like water, but is primarily more soluble in organic solvents such as ethanol or acetone.
  • Influence of Functional Groups: The presence of the ether and amine groups enhances hydrogen bonding potential, which may lead to increased solubility in organic solvent mixtures.
  • Thermodynamic Considerations: Temperature can also influence solubility; generally, as temperature increases, the solubility of organic compounds tends to improve.

In conclusion, while precise solubility data may vary, understanding the compound's polarity and functional groups is crucial for predicting solubility behavior. As a general guideline, it is often noted that "like dissolves like," thus, this compound would likely show a preference for solubility in organic environments where similar characteristics are present.

Interesting facts

Interesting Facts about 2-(diethylamino)ethyl 3-(2-furyl)-2-(1-naphthyl)propanoate

This compound belongs to the class of esthers and is notable for its potential applications in various pharmaceutical contexts. The unique combination of functional groups in its structure opens up several intriguing avenues for research and development.

Key Features

  • The Furyl Group: The presence of the furyl moiety contributes to the compound's aromatic character, which may enhance its interactions with biological targets. Furan derivatives are known for their diverse biological activities.
  • Naphthyl Component: The inclusion of the naphthyl group provides additional stability and can potentially improve the lipophilicity of the compound, which affects its pharmacokinetic properties.
  • Diethylamino Functionality: The diethylamino group is often linked with enhanced nucleophilicity, which may facilitate various chemical reactions or enhance binding affinity in biological systems.

Researchers find compounds like this particularly interesting due to their ability to interact with specific receptors or enzymes, paving the way for the development of novel therapeutic agents. Moreover, the intricate structure-activity relationship provides a rich area for investigation, allowing chemists to modify different portions of the molecule to optimize its biological activity.

In summary, the molecular architecture of 2-(diethylamino)ethyl 3-(2-furyl)-2-(1-naphthyl)propanoate makes it a fascinating compound with potential in medicinal chemistry, offering an intersection of synthetic organic chemistry and pharmacology. As always, careful research is essential to elucidate its full potential!

Synonyms
3216-74-8
2-(Diethylamino)ethyl alpha-(2-furylmethyl)-1-naphthaleneacetate
BRN 1267505
2''-(N,N-Diethylamino)ethyl alpha-(2'-furyl)methyl-1-naphthaleneacetate
1-Naphthaleneacetic acid, alpha-(2'-furyl)methyl-, 2''-(N,N-diethylamino)ethyl ester
DTXSID60954035
2-(diethylamino)ethyl 3-(furan-2-yl)-2-(naphthalen-1-yl)propanoate