Loperamide | Solubility of Things

Identification

Molecular formula

C₂₉H₃₃NO₂Si

CAS number

53179-11-6

IUPAC name

2-(diethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate

State

At room temperature, loperamide is in a solid state. As it is an active pharmaceutical ingredient, it is most commonly found in oral formulations such as tablets or capsules when distributed for consumer use.

Melting point (Celsius)

209.00

Melting point (Kelvin)

482.15

Boiling point (Celsius)

476.15

Boiling point (Kelvin)

749.30

General information

Molecular weight

477.76g/mol

Molar mass

477.7560g/mol

Density

1.1000g/cm³

Appearence

Loperamide typically appears as a white or slightly off-white crystalline powder. It is odorless or may have a faint characteristic odor. The compound is generally supplied in powdered form, which can be further processed for pharmaceutical formulations.

Comment on solubility

Solubility of 2-(diethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate

The solubility of 2-(diethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate is an important characteristic that influences its application and functionality in various fields. Understanding solubility can provide insights into this compound's behavior in different environments. Here are some key points regarding its solubility:

Polar vs. Non-Polar Solvents: This compound is likely soluble in polar solvents due to the presence of functional groups such as the hydroxyl (-OH) and amine (–NH) groups which can form hydrogen bonds. However, its diethylamino and trimethylsilyl substituents may impart some lipophilicity.
Aqueous Solubility: The solubility in water will depend on the balance between hydrophilic (water-attracting) and hydrophobic (water-repelling) parts of the molecule. The presence of multiple functional groups suggests a moderate to high aqueous solubility.
Temperature Dependency: Like many organic compounds, solubility can be affected by temperature; typically, increased temperature leads to increased solubility in most solvents.
pH Effects: As this compound contains basic amine groups, its solubility may also vary with pH. Under acidic conditions, these groups can become protonated, enhancing solubility in aqueous environments.

In conclusion, while specific solubility data would provide better clarity, the functional characteristics of 2-(diethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate suggest favorable solubility behavior, primarily in polar solvents and influenced by several external factors.

Interesting facts

Interesting Facts about 2-(diethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate

2-(diethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate is a fascinating compound that belongs to the class of esters. It combines different functional groups, making it of great interest in various fields of chemistry.

Key Features:

Diverse Functional Groups: This compound features an ether, an amine, and an ester. This diverse array allows for unique reactivity and potential applications.
Pharmaceutical Relevance: Compounds similar to this have been investigated in pharmaceutical research due to their potential biological activity. The presence of the diethylamino group may contribute to its interaction with biological systems.
Silicon in Chemistry: The incorporation of a trimethylsilyl group indicates its application in organosilicon chemistry. These groups are often employed to enhance the solubility and stability of organic compounds.

As a scientist, one might consider the implications of this compound in drug design, particularly for targeting specific biological pathways. According to chemists, “The interaction between the functional groups can lead to enhancements in bioactivity.”

Furthermore, understanding such compounds can pave the way for innovations in material science, especially in creating stable formulations for various applications.

In summary, 2-(diethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate is not only a structured molecule with potential applications but also a demonstration of how various functional groups can harmoniously interact to yield new and exciting properties.