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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
2-(diethylamino)ethyl 4-[4-(1-piperidyl)but-2-enyl]benzoate
State
State

At room temperature, lidocaine is typically a solid in its pure form. However, it is often used in various formulations that can be in liquid or gel states for medical applications, especially for its anesthetic properties.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3390g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is commonly available as a white to off-white crystalline powder. It is practically odorless and has a slightly bitter taste. The powder is often used in its base form for topical applications or as a hydrochloride salt for injectable preparations.

Comment on solubility

Solubility of 2-(diethylamino)ethyl 4-[4-(1-piperidyl)but-2-enyl]benzoate

The solubility of 2-(diethylamino)ethyl 4-[4-(1-piperidyl)but-2-enyl]benzoate can be influenced by several factors due to its complex molecular structure. Understanding solubility is essential for applications in pharmaceuticals and other chemical industries. Here are some key points regarding its solubility:

  • Polarity: The presence of both hydrophilic (amino) and hydrophobic (benzene ring) components suggests a possible amphiphilic nature. This can lead to varied solubility in polar and non-polar solvents.
  • pH Dependence: The solubility may change with pH, especially if the compound can ionize in solution. Therefore, testing in different pH environments is crucial.
  • Temperature Effects: Increasing temperature generally enhances solubility; however, the degree of this effect can vary significantly based on the chemical characteristics of the compound.
  • Solvent Interactions: It is likely that 2-(diethylamino)ethyl 4-[4-(1-piperidyl)but-2-enyl]benzoate is more soluble in organic solvents such as ethanol or dichloromethane compared to water due to its largely organic nature.

In conclusion, the solubility profile of this compound is complex and may necessitate experimental validation to determine the best solvent conditions for its intended applications. Understanding its solubility is crucial for optimizing formulations and ensuring effectiveness in its use.

Interesting facts

Interesting Facts About 2-(diethylamino)ethyl 4-[4-(1-piperidyl)but-2-enyl]benzoate

This compound, with its complex structure, is part of a class of chemical compounds known as benzoates. It’s particularly intriguing due to its potential applications in medicinal chemistry and the pharmacological field.

  • Pharmacological Relevance: Compounds similar to 2-(diethylamino)ethyl 4-[4-(1-piperidyl)but-2-enyl]benzoate have been studied for their potential as antidepressants, showcasing their importance in mental health research.
  • Structure Activity Relationships (SAR): The specific arrangement of the functional groups in this compound allows for the exploration of its interaction with biological targets, making it a crucial subject in SAR studies.
  • Amine Functionality: The presence of diethylamino groups contributes to its basic character, influencing its reactivity and solubility in different mediums, which is vital in drug formulation.
  • Potential for Synthesis: Its synthesis can vary based on the desired properties, allowing chemists to modify the compound to enhance efficacy or reduce side effects when developed as a therapeutic agent.

In the broader context of organic chemistry, compounds like this showcase the fascinating intersection between structure, function, and therapeutic potential, prompting continual research and innovation to understand how slight changes can lead to significantly different biological effects.

Furthermore, the exploration of the compound's potential can inspire new treatments, making its study not just an academic pursuit but a frontier in improving human health.