Interesting facts
Exploring 2-(Diethylamino)ethyl 4-aminobenzoate
2-(Diethylamino)ethyl 4-aminobenzoate, commonly known as a local anesthetic, plays a significant role in medicinal chemistry and pharmacology. Here are some intriguing insights about this compound:
- Mechanism of Action: This compound acts by blocking sodium channels in nerve cells, which inhibits the transmission of pain signals. This mechanism is essential for its use as an anesthetic.
- Applications: It is widely used in medical procedures to provide localized pain relief. Its effectiveness makes it a valuable tool in both dental and surgical settings.
- Synthesis: The synthesis of 2-(diethylamino)ethyl 4-aminobenzoate is an interesting process that typically involves the reaction of diethylaminoethanol with 4-aminobenzoic acid, showcasing the beauty of organic synthesis.
- Structure Activity Relationship (SAR): The unique structure of this compound, especially the diethylamino group and the aromatic amine, is critical for its anesthetic properties. Modifications to this structure can alter potency and efficacy.
- Toxicology and Safety: Like many anesthetics, it is important to balance efficacy and safety. Understanding its pharmacokinetics and potential side effects is crucial for safe usage in patients.
As one delves deeper into the world of 2-(diethylamino)ethyl 4-aminobenzoate, they appreciate not just the chemical aspects but also its significant impact on patient care and pain management.
Synonyms
procaine
59-46-1
2-(Diethylamino)ethyl 4-aminobenzoate
Vitamin H3
Novocaine
Spinocaine
Duracaine
Procain
Nissocaine
Procaina
Procaine, base
Procainum
Novocain
Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester
Norocaine
2-Diethylaminoethyl p-aminobenzoate
2-Diethylaminoethyl 4-aminobenzoate
Diethylaminoethyl p-aminobenzoate
Factor H3
Jenacain
Stoff H3
p-Aminobenzoyldiethylaminoethanol
p-Aminobenzoic acid 2-diethylaminoethyl ester
Procainum [INN-Latin]
Procaina [INN-Spanish]
Scurocaine
4-Aminobenzoic acid diethylaminoethyl ester
beta-Diethylaminoethyl 4-aminobenzoate
2-(Diethylamino)ethyl-4-aminobenzoate
CHEBI:8430
NSC 169497
beta-(Diethylamino)ethyl 4-aminobenzoate
beta-(Diethylamino)ethyl p-aminobenzoate
HSDB 3388
Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester
EINECS 200-426-9
2-(Diethylamino)ethyl p-aminobenzoate
Procaine (INN)
4-Aminobenzoesaeure-beta-diethylaminoethylester
NSC-169497
BRN 0913480
PROCAINE BASE
UNII-4Z8Y51M438
4-Aminobenzoic acid 2-diethylaminoethyl ester
MFCD00007893
2-Diethylaminoethylester kyseliny p-aminobenzoove
4Z8Y51M438
DTXSID7045021
Gerovital
4-Amino-benzoic acid 2-diethylamino-ethyl ester
SP-01
4-14-00-01138 (Beilstein Handbook Reference)
NSC169497
Procainum (INN-Latin)
PROCAINE [INN]
.beta.-(Diethylamino)ethyl p-aminobenzoate
Procaina (INN-Spanish)
Procaine [INN:BAN]
Gerovital H-3
MLS001304095
Anticort (TM)
CAS-51-05-8
NCGC00015864-02
SMR000718771
2-Diethylaminoethylester kyseliny p-aminobenzoove [Czech]
SP01
Neocaine (Salt/Mix)
Novocain (Salt/Mix)
Allocaine (Salt/Mix)
Novocaine (Salt/Mix)
Sevicaine (Salt/Mix)
Spectrum_000838
Aminocaine (Salt/Mix)
Scurocaine (Salt/Mix)
PROCAINE [HSDB]
PROCAINE [MI]
Neotonocaine (Salt/Mix)
PROCAINE [VANDF]
Prestwick0_000041
Prestwick1_000041
Prestwick2_000041
Prestwick3_000041
Spectrum2_001296
Spectrum3_000556
Spectrum4_000488
Spectrum5_001186
Lopac-P-9879
CHEMBL569
Epitope ID:115010
PROCAINE [WHO-DD]
Gerovital H3 (Salt/Mix)
cid_5795
SCHEMBL3524
4-aminobenzoic acid 2-(diethylamino)ethyl ester
SAMPL3, G2
Lopac0_000966
BSPBio_000161
BSPBio_002231
KBioGR_000975
KBioSS_001318
DivK1c_000120
SPBio_001331
SPBio_002082
WLN: ZR DVO2N2&2
BPBio1_000179
GTPL4291
DTXCID5025021
BDBM64452
KBio1_000120
KBio2_001318
KBio2_003886
KBio2_006454
KBio3_001731
C05AD05
N01BA02
S01HA05
NINDS_000120
HMS3885F16
HY-B0546
BBL005106
s4668
STK177303
AKOS000115407
CCG-205046
DB00721
DS-1216
SDCCGSBI-0050939.P005
IDI1_000120
.beta.-Diethylaminoethyl 4-aminobenzoate
NCGC00015864-01
NCGC00015864-03
NCGC00015864-04
NCGC00015864-18
NCGC00162298-01
DA-57051
FP140525
SY030284
SBI-0050939.P004
.beta.-(Diethylamino)ethyl 4-aminobenzoate
aniline, 4-(2-diethylamino)ethoxycarbonyl-
2-(N,N-diethylamino)ethyl 4-amino-benzoate
AB00053531
NS00000182
P1961
EN300-33930
C07375
D08422
AB00053531-09
AB00053531_11
AB00053531_12
p-Aminobenzoic acid, 2-(diethylamino)ethyl ester
AE-641/00560024
Q423741
2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
2-(diethylamino)ethyl 4-azanylbenzoate;hydrochloride
Benzoic acid, 4-amino- 2-(diethylamino)ethyl ester
BRD-K24616672-003-05-2
BRD-K24616672-003-10-2
BRD-K24616672-003-19-3
BRD-K24616672-003-20-1
4-Aminobenzoic acid 2-(diethylamino) ethyl ester;Novocaine
4-aminobenzoic acid 2-(diethylamino)ethyl ester;hydrochloride
BENZOIC ACID,4-AMINO,2-DIETHYLAMINOETHYL ESTER PROCAIN BASE
200-426-9
InChI=1/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H
Solubility of 2-(diethylamino)ethyl 4-aminobenzoate
The solubility of the compound 2-(diethylamino)ethyl 4-aminobenzoate (C9H11NO2) is influenced by various factors, particularly due to its molecular structure. Several key points to consider include:
In practical applications, the solubility of this compound can be described in qualitative terms, with examples stating its potential to dissolve in ethanol and methanol, but may face challenges in non-polar solvents such as hexane.
Overall, understanding the solubility profile of 2-(diethylamino)ethyl 4-aminobenzoate can provide valuable insights for its utilization in various chemical processes and formulations.