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Procaine

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Identification
Molecular formula
C13H20N2O2
CAS number
59-46-1
IUPAC name
2-(diethylamino)ethyl 4-aminobenzoate;2-(5-oxopyrrolidin-2-yl)acetic acid
State
State
Procaine is typically in a solid state at room temperature. It is handled as a powder, which is then often dissolved for pharmaceutical applications.
Melting point (Celsius)
61.00
Melting point (Kelvin)
334.15
Boiling point (Celsius)
378.00
Boiling point (Kelvin)
651.15
General information
Molecular weight
236.31g/mol
Molar mass
236.3110g/mol
Density
1.1700g/cm3
Appearence

Procaine appears as a white, crystalline powder. It is odorless and has a slightly bitter taste. The compound tends to be highly soluble in water, which is characteristic of many amino ester local anesthetics. When dissolved, it forms a clear, colorless solution.

Comment on solubility

Solubility of 2-(diethylamino)ethyl 4-aminobenzoate; 2-(5-oxopyrrolidin-2-yl)acetic acid

The solubility of the compound 2-(diethylamino)ethyl 4-aminobenzoate; 2-(5-oxopyrrolidin-2-yl)acetic acid can be intriguing due to its unique structure. This compound exhibits varying solubility characteristics influenced by several factors:

  • Polarity: The presence of both amine and carboxylic acid functional groups contributes to the overall polarity, which enhances solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to participate in hydrogen bonding can significantly affect solubility. The amine group may offer sites for interaction with polar solvents, leading to increased solubility.
  • Alkyl Groups: The diethylamino group is more hydrophobic and can influence the solubility in non-polar solvents. The balance between hydrophilic and hydrophobic portions is crucial for determining solubility.
  • pH Sensitivity: The solubility may also change depending on the pH of the solution. For example, protonation of the amine in acidic conditions can enhance water solubility.

In summary, the solubility behavior of this compound is a consequence of its structural features, allowing it to be soluble in a variety of solvents under different conditions. As a rule of thumb, like dissolves like, which means that the compound may be more soluble in polar solvents than in non-polar ones, especially considering the functional groups present.

Interesting facts

Exploring 2-(diethylamino)ethyl 4-aminobenzoate and 2-(5-oxopyrrolidin-2-yl)acetic acid

The compounds 2-(diethylamino)ethyl 4-aminobenzoate and 2-(5-oxopyrrolidin-2-yl)acetic acid reveal fascinating insights into the world of chemistry and medicinal applications. These compounds, although complex in structure, play significant roles in various fields, particularly in pharmacology and biochemistry.

Key Facts:

  • Pharmaceutical Significance: The first compound, 2-(diethylamino)ethyl 4-aminobenzoate, is often studied for its potential as a local anesthetic. This compound can function effectively by blocking nerve signals in the body.
  • Structural Versatility: The presence of the diethylamino group lends this chemical a degree of lipophilicity, which can enhance its penetration through biological membranes, making it an interesting subject of study for drug design.
  • Interaction with Biological Systems: Its amino and ester functionalities allow it to interact with various biological molecules, proposing different mechanisms of activity that may lead to innovations in therapeutic applications.
  • Cyclic Elements: On the other hand, 2-(5-oxopyrrolidin-2-yl)acetic acid contributes to the understanding of cyclic organic compounds in medicinal chemistry. The pyrrolidine ring can provide advantageous properties in drug development, potentially affecting how the molecule interacts with receptors and enzymes in the body.

As we deepen our understanding of these compounds, we can highlight their importance not only in developing effective pharmaceuticals but also in enhancing our overall knowledge of organic chemistry. As stated by renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." These compounds exemplify this spirit, contributing numerous ideas for researchers to explore.

In summary, the exploration of 2-(diethylamino)ethyl 4-aminobenzoate and 2-(5-oxopyrrolidin-2-yl)acetic acid opens a gateway to both theoretical understanding and practical applications, making them invaluable in the realms of chemical science and medicinal research.

Synonyms
2-diethylaminoethyl 4-aminobenzoate; 2-(5-oxopyrrolidin-2-yl)acetic acid
10248-52-9
DTXSID00274784
5-Oxoproline,compound with 2-(diethylamino)ethyl 4-aminobenzoate(1:1)