Skip to main content

Articaine

ADVERTISEMENT
Identification
Molecular formula
C13H20FN1O3
CAS number
23964-57-0
IUPAC name
2-(diethylamino)ethyl 4-ethoxy-3-fluoro-benzoate
State
State

Articaine, in its base form, is a solid at room temperature. It is typically distributed as a hydrochloride salt for medical applications, where it is dissolved in a solution for injection.

Melting point (Celsius)
79.80
Melting point (Kelvin)
353.00
Boiling point (Celsius)
248.30
Boiling point (Kelvin)
521.45
General information
Molecular weight
284.36g/mol
Molar mass
284.3630g/mol
Density
1.0763g/cm3
Appearence

Articaine is a white, crystalline powder with no significant odor. It is often used in the form of its hydrochloride salt, which enhances its water solubility for clinical use.

Comment on solubility

Solubility of 2-(diethylamino)ethyl 4-ethoxy-3-fluoro-benzoate

The solubility of the compound 2-(diethylamino)ethyl 4-ethoxy-3-fluoro-benzoate is influenced by several factors, primarily its molecular structure and the presence of functional groups. This compound contains both hydrophobic and hydrophilic components, which can significantly affect its solubility in various solvents.

Key considerations regarding the solubility include:

  • Polarity: The presence of the diethylamino group contributes to the polar character, while the ethoxy and benzoate structures tend to be more nonpolar.
  • Solvent Compatibility: This compound is likely to be soluble in organic solvents such as ethanol or acetonitrile, but may have limited solubility in water due to its overall hydrophobic character.
  • Temperature Dependence: Solubility can vary significantly with temperature; increasing the temperature generally increases solubility in organic solvents.

In summary, the solubility of 2-(diethylamino)ethyl 4-ethoxy-3-fluoro-benzoate is a balance between its polar and nonpolar characteristics, leading to greater solubility in organic solvents and limited solubility in water. Understanding these factors is crucial for applications in pharmaceuticals and chemical synthesis, as solubility directly impacts the bioavailability and efficacy of the compound.

Interesting facts

Interesting Facts about 2-(diethylamino)ethyl 4-ethoxy-3-fluoro-benzoate

2-(diethylamino)ethyl 4-ethoxy-3-fluoro-benzoate is an intriguing compound that catches the attention of both chemists and pharmacologists. Here are some fascinating aspects of this compound:

  • Diverse Applications: This compound, being a benzoate derivative, is pertinent in medicinal chemistry and has potential applications in drug discovery due to its structural properties.
  • Unique Structure: The presence of the diethylamino group introduces interesting electronic properties that can enhance its reactivity and interaction profiles.
  • Fluorine's Role: The incorporation of fluorine into the molecule often boosts its metabolic stability and can modify the lipophilicity, making it a prime candidate for pharmaceutical applications.
  • Research Potential: Compounds like this one are frequently investigated for their biological activities, offering opportunities for the development of new medications.
  • Design Strategy: The functional groups present allow for various synthetic modifications, making it a versatile scaffold for developing new chemical entities.

This compound embodies the delicate interplay of chemistry and pharmacology, spotlighting how nuanced structural features can lead to significant biological effects. Exploring such compounds can uncover new pathways for therapeutic interventions and provide insight into the foundation of drug design.