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Diphenoxylate

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Identification
Molecular formula
C30H32NO2
CAS number
915-30-0
IUPAC name
2-(diethylamino)propyl 2,2-diphenylacetate
State
State

At room temperature, diphenoxylate is in a solid state. It is usually handled in a dry environment to maintain its structural integrity.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.10
Boiling point (Celsius)
407.89
Boiling point (Kelvin)
681.04
General information
Molecular weight
452.58g/mol
Molar mass
452.5840g/mol
Density
1.0728g/cm3
Appearence

Diphenoxylate is typically seen as a white to off-white, crystalline powder. It is often used in a hydrochloride salt form for its pharmacological applications. The solid substance is not particularly hygroscopic and remains stable under standard temperature and pressure conditions.

Comment on solubility

Solubility of 2-(diethylamino)propyl 2,2-diphenylacetate

The solubility of 2-(diethylamino)propyl 2,2-diphenylacetate can be described through a few key aspects:

  • Solvent Dependency: This compound typically exhibits varying solubility depending on the solvent used. In general, it is more soluble in organic solvents compared to water.
  • Polar vs. Non-Polar: Being a relatively non-polar molecule due to the large diphenylacetate group, it is less soluble in polar solvents like water but shows enhanced solubility in non-polar solvents such as hexane or dichloromethane.
  • Temperature Effects: Increasing temperature can improve the solubility of the compound in organic solvents, demonstrating the importance of thermodynamic conditions.
  • pH Sensitivity: The ionization state of the diethylamino group may influence its solubility; under different pH conditions, this could alter its overall solubility profile.

Overall, it is essential to consider the solubility behavior of 2-(diethylamino)propyl 2,2-diphenylacetate in various solvents to understand its potential applications and reactivity in synthetic processes. As expressed by the phrase, "Like dissolves like", the choice of solvent plays a critical role in the solubility of this compound.

Interesting facts

Interesting Facts about 2-(Diethylamino)propyl 2,2-diphenylacetate

2-(Diethylamino)propyl 2,2-diphenylacetate, often referred to in the realm of organic synthesis, is a fascinating compound with a unique structure and intriguing applications. Here are some notable aspects:

  • Functional Versatility: This compound features both a diethylamino group and a diphenylacetate moiety, which allows it to exhibit interesting reactivity patterns. It can serve as a precursor in the synthesis of various pharmaceuticals and biologically active molecules.
  • Pharmacological Potential: Research has indicated that compounds containing the diethylamino group may possess significant pharmacological properties. They can interact with biological systems in ways that may lead to therapeutic effects, making them of particular interest in medicinal chemistry.
  • Chirality and Isomerism: The presence of a chiral center in this molecule adds another layer of complexity, as it can exist in multiple stereoisomeric forms. This feature is crucial, as the biological activity of isomers can vary significantly.
  • Historical Significance: Compounds like 2-(diethylamino)propyl 2,2-diphenylacetate are often studied in the context of drug development and formulation science, contributing to the vast knowledge of organic chemistry.

As noted in various journals, “the exploration of derivatives like 2-(diethylamino)propyl 2,2-diphenylacetate not only deepens our understanding of structure-activity relationships but also opens avenues for innovation in therapeutic agents.” This underscores the importance of such compounds in ongoing research.

In summary, the study of 2-(diethylamino)propyl 2,2-diphenylacetate not only enriches the field of organic synthesis but also offers profound implications for future pharmaceutical developments.

Synonyms
2-(Diethylamino)propyl 2,2-diphenylacetate
2902-99-0
BRN 2471488
2,2-Diphenylacetic acid 2-(diethylamino)propyl ester
ACETIC ACID, 2,2-DIPHENYL-, 2-(DIETHYLAMINO)PROPYL ESTER
DTXSID80951627
2-(diethylamino)propyl diphenylacetate