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Pirfenidone

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Identification
Molecular formula
C12H11NO2
CAS number
53179-13-8
IUPAC name
2-(diisopropylamino)ethyl 3-methyl-4-oxo-2-phenyl-chromene-8-carboxylate
State
State

At room temperature, Pirfenidone is typically found as a solid in the form of a crystalline powder.

Melting point (Celsius)
80.00
Melting point (Kelvin)
353.20
Boiling point (Celsius)
476.60
Boiling point (Kelvin)
749.80
General information
Molecular weight
248.31g/mol
Molar mass
248.3120g/mol
Density
1.2447g/cm3
Appearence

Pirfenidone is a white to creamy-white crystalline powder. It is nearly insoluble in water, but soluble in alcohols and organic solvents.

Comment on solubility

Solubility of 2-(diisopropylamino)ethyl 3-methyl-4-oxo-2-phenyl-chromene-8-carboxylate

The solubility of 2-(diisopropylamino)ethyl 3-methyl-4-oxo-2-phenyl-chromene-8-carboxylate can be described as follows:

  • Solvent Dependency: Its solubility is greatly influenced by the choice of solvent, typically exhibiting better solubility in organic solvents compared to aqueous environments.
  • Hydrophobic Characteristics: The presence of various hydrophobic groups in the structure contributes to low solubility in polar solvents, which can limit its application in aqueous systems.
  • Temperature Influence: Like many organic compounds, increased temperature can enhance solubility, providing more flexibility in experimental conditions.
  • Concentration Limits: At higher concentrations, precipitation may occur, indicating a saturation point that should be carefully monitored.

Overall, if you're working with this compound, it’s essential to consider the aforementioned factors for effective use in various chemical applications. For instance, the quote "Like dissolves like" often holds true, emphasizing that the polarity of the solvent should be matched to maximize solubility.

Interesting facts

Interesting Facts about 2-(diisopropylamino)ethyl 3-methyl-4-oxo-2-phenyl-chromene-8-carboxylate

This intriguing compound belongs to the class of chromene derivatives, known for their diverse biological activities and applications in medicinal chemistry. Its complex structure incorporates various functional groups, contributing to its potential pharmacological properties.

Biological Significance

2-(diisopropylamino)ethyl 3-methyl-4-oxo-2-phenyl-chromene-8-carboxylate has been researched for its potential in:

  • Antioxidant Activity: The chromene structure can scavenge free radicals, making it useful in combating oxidative stress.
  • Anticancer Properties: Some derivatives of chromene have displayed the ability to inhibit cancer cell proliferation.
  • Neuroprotective Effects: Compounds with similar structures have shown promise in protecting neuronal cells from damage.

Applications in Research

This compound's unique attributes make it a focal point in various fields:

  • Drug Development: Its pharmacological potential opens pathways for new therapeutic agents.
  • Material Science: Chromene derivatives are also being studied for their applications in creating advanced materials due to their structural resilience.

Synthesis and Modification

Synthesizing 2-(diisopropylamino)ethyl 3-methyl-4-oxo-2-phenyl-chromene-8-carboxylate involves intricate organic reactions, and the ability to modify its structure can lead to optimization of its beneficial properties. Researchers often exploit:

  • Varied substitution patterns to enhance biological activity.
  • Differences in stereochemistry to study effects on interaction with biological targets.

In summary, 2-(diisopropylamino)ethyl 3-methyl-4-oxo-2-phenyl-chromene-8-carboxylate is not just a molecule of interest; it represents the intersection of organic chemistry, pharmacology, and material science, showcasing how a single compound can embody complex interrelationships within scientific inquiry.