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Nitrofurantoin

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
[2-(dimethylamino)-2-methyl-propyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate
State
State

At room temperature, nitrofurantoin is in the solid state. It is typically encountered as a crystalline powder.

Melting point (Celsius)
316.00
Melting point (Kelvin)
589.15
Boiling point (Celsius)
665.00
Boiling point (Kelvin)
938.15
General information
Molecular weight
238.16g/mol
Molar mass
238.1560g/mol
Density
1.6800g/cm3
Appearence

Nitrofurantoin appears as a yellow crystalline solid. It is known for its intense color and is used in its pure form as well as in formulations.

Comment on solubility

Solubility of [2-(dimethylamino)-2-methyl-propyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate

The solubility of a compound like [2-(dimethylamino)-2-methyl-propyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate can greatly influence its application and behavior in various contexts. Understanding its solubility is crucial for determining how it interacts with solvents and biological systems. Here are some key points regarding its solubility:

  • Polar vs. Nonpolar: The presence of polar functional groups in the isoxazole and carboxylate moieties may enhance solubility in polar solvents, whereas the presence of hydrophobic regions can mean limited solubility in water.
  • Temperature Dependence: Solubility is often temperature-dependent; increasing temperatures can lead to improved solubility in some cases, while decreasing temperatures may precipitate the compound.
  • pH Considerations: For carboxylate compounds, the solubility can vary significantly with the pH of the solution. An increase in pH may lead to deprotonation, which can enhance solubility.
  • Solvent Choice: The choice of solvent plays a crucial role; organic solvents like methanol or ethanol may dissolve this compound better than water.

In summary, the solubility characteristics of [2-(dimethylamino)-2-methyl-propyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate are likely influenced by both its chemical structure and the surrounding conditions. To fully understand its practical applications, further experimental studies are recommended.

Interesting facts

Interesting Facts about [2-(dimethylamino)-2-methyl-propyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate

This intriguing compound belongs to a fascinating class of chemicals known for their diverse applications in pharmaceutical and agricultural industries. The compound is characterized by its complex structure which includes a dimethylamino group and an isoxazole ring, providing it with unique properties that can lead to various biological activities.

Key Features

  • Biological Activity: Compounds like this one often display interesting biological activities, including potential anti-inflammatory and antimicrobial properties.
  • Chemical Versatility: The inclusion of both a furyl group and a carboxylate moiety enhances the chemical's reactivity, allowing it to participate in numerous chemical reactions which can be harnessed for synthesis in research and development.
  • Structure-Activity Relationship: The structural complexity of this compound lends itself well to studying structure-activity relationships (SAR), pivotal in drug design.

The synthesis of [2-(dimethylamino)-2-methyl-propyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate can be a subject of interest in organic chemistry labs, illustrating various synthetic methods such as condensation reactions and cyclization techniques.

Potential Research Applications

  • Research into new pharmaceuticals that could lead to the development of innovative therapies.
  • Investigating its use in agricultural chemistry as a potential pesticide.
  • Studying its interactions with biological systems for medicinal chemistry applications.

As scientists continue to explore the potential of 2-(dimethylamino)-2-methyl-propyl 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carboxylate, its complexity and utility could prove invaluable in advancing chemical science. The possibility of discovering new therapeutic agents stemming from this compound highlights the richness of chemistry and its capacity to innovate.

Synonyms
21709-31-9
4-Isoxazolecarboxylic acid, 5-methyl-3-(5-nitro-2-furyl)-, 2-(dimethylamino)-2-methylpropyl ester
DTXSID40176096