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Nitrofurantoin

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
[2-(dimethylamino)acetyl]-[(5-nitro-2-furyl)methyleneamino]ammonium;chloride
State
State

At standard room temperature, nitrofurantoin is found as a solid compound. It is used in powder or microcrystalline forms in pharmaceutical applications.

Melting point (Celsius)
314.00
Melting point (Kelvin)
587.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
238.16g/mol
Molar mass
238.1560g/mol
Density
1.6090g/cm3
Appearence

Nitrofurantoin is a yellow crystalline solid in its pure form. When formulated as a drug, it is often found in a microcrystalline form which appears slightly different in commercial preparations. It may appear less vibrant due to formulation excipients.

Comment on solubility

Solubility of [2-(dimethylamino)acetyl]-[(5-nitro-2-furyl)methyleneamino]ammonium;chloride

The solubility of the compound [2-(dimethylamino)acetyl]-[(5-nitro-2-furyl)methyleneamino]ammonium;chloride is influenced by its ionic nature and functional groups. Here are some key points to consider:

  • Ionic Interaction: As an ammonium chloride compound, it typically exhibits good solubility in polar solvents such as water due to the ionic interactions that occur between the ammonium cation and chloride anion.
  • Polar Functional Groups: The presence of dimethylamino and nitro groups enhances its solubility in polar solvents, allowing for potential dissolution.
  • Temperature Dependency: Like many salts, solubility can increase with temperature, so evaluating solubility at different temperatures can yield varying results.
  • pH Effects: The solubility may also be affected by the pH of the solution, which can influence the protonation state of the amine group, altering its solubility characteristics.

In summary, due to its ionic nature and polar functional groups, one can expect a significant solubility in water, but experimental measurements are essential to confirm the exact solubility behavior under varying conditions.

Interesting facts

Interesting Facts about [2-(Dimethylamino)acetyl]-[(5-Nitro-2-furyl)methyleneamino]ammonium Chloride

[2-(Dimethylamino)acetyl]-[(5-nitro-2-furyl)methyleneamino]ammonium chloride, often referred to in various research contexts, is a compound that exhibits intriguing properties and potential applications in the realm of medicinal chemistry.

Key Highlights

  • Pharmacological Potential: This compound may exhibit significant activities, particularly in the field of anti-cancer research. The presence of the furyl ring and nitro group enhances its reactivity and interaction with biological molecules, potentially leading to the development of new therapeutics.
  • Structure-Activity Relationship (SAR): Understanding the structure of this compound provides valuable insights into how modifications can affect its biological activity. For instance, changes to the dimethylamino group can influence its ability to penetrate cell membranes.
  • Multi-Functional Applications: Beyond its pharmaceutical applications, compounds like this one can serve in the development of sensors or organic electronics, showcasing its versatility in different fields of science.
  • Environmental Concerns: As with many synthetic compounds, the environmental impact and degradation must be considered, especially in drug development and disposal practices.

This compound is a fine example of the intricate designs found in organic chemistry that can lead to beneficial applications in healthcare and technology. The ongoing research into such chemicals not only enriches our understanding but also opens the door to novel innovation.

Conclusion

In summary, [2-(dimethylamino)acetyl]-[(5-nitro-2-furyl)methyleneamino]ammonium chloride stands as a compelling subject for ongoing research and discovery in the chemical sciences. Its unique properties, potential therapeutic benefits, and multi-faceted applications make it a worthy focus for students and scientists alike.