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Cyclopentolate hydrochloride

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Identification
Molecular formula
C17H25NO3·HCl
CAS number
5870-29-1
IUPAC name
2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenyl-acetate;hydrochloride
State
State

Cyclopentolate hydrochloride is typically solid at room temperature.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
325.20
Boiling point (Kelvin)
598.35
General information
Molecular weight
327.87g/mol
Molar mass
327.8650g/mol
Density
1.1950g/cm3
Appearence

Cyclopentolate hydrochloride appears as white, crystalline powder. It is known for its solubility in water and has no characteristic odor.

Comment on solubility

Solubility of 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenyl-acetate; hydrochloride

The solubility of the compound 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenyl-acetate; hydrochloride is an intriguing aspect, as it influences its behavior in various chemical environments. This compound, classified as a hydrochloride salt, generally exhibits a higher solubility in water compared to its free base form. This can be attributed to the presence of the ionic hydrochloride group, which enhances its interactions with water molecules.

  • Solubility in Water: As a hydrochloride, this compound is expected to be soluble in aqueous solutions, largely due to the positive charge of the ammonium group from the dimethylamino moiety.
  • Effect of pH: The solubility may vary with changes in pH levels, as the protonation state of the amine can significantly impact its solubility profile.
  • Solvents: It is also likely to have varying degrees of solubility in other solvents; for example, organic solvents might yield lower solubility.

It is essential to consider temperature and pressure as factors that also influence solubility. Typically, increasing temperature can improve solubility in many cases, while pressure plays a more complex role, primarily affecting gaseous solubility.

In conclusion, understanding the solubility dynamics of 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenyl-acetate; hydrochloride not only aids in practical applications but also enhances our comprehension of its chemical behavior in solution.

Interesting facts

Interesting Facts about 2-(Dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenyl-acetate; Hydrochloride

This compound is a fascinating example of how complex organic chemistry can create molecules with significant therapeutic potential. Often categorized as a pharmaceutical intermediate, it showcases how structural intricacies can influence biological activity.

Key Features:

  • Pharmacological Relevance: This compound may exhibit properties that could be useful in the development of new medications. Its structure suggests potential interactions with various biological pathways, typically seen in compounds designed for neurological or cardiovascular treatments.
  • Synthetic Versatility: The synthesis of this compound involves multiple reaction steps, demonstrating the creativity and precision needed in organic synthesis. It serves as an excellent case study for students learning about reaction mechanisms and functional group transformations.
  • Substituent Influence: The presence of dimethylamino and hydroxycyclopentyl groups highlights the importance of branching in alkyl chains, which can greatly enhance a compound's pharmacokinetic properties such as solubility and permeability.

Implications in Research:

This molecule is not only a subject of interest for drug development but also a potential lead compound for further exploration. Researchers can investigate its interactions at a molecular level to identify how subtle changes in its structure may lead to different biological outcomes. In their quest for new therapies, scientists often refer to such compounds, stating:

“Understanding the nuances of structure-activity relationships is fundamental in medicinal chemistry.”

In summary, 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenyl-acetate; hydrochloride is more than just a complex molecule; it embodies the intersection of chemistry, biology, and pharmacology, making it an exciting area of study for future medicinal advancements.

Synonyms
CYCLOPENTOLATE HYDROCHLORIDE
5870-29-1
Cyclopentolate HCL
Cyplegin
AK-Pentolate
Mydrilate
Pentolair
Akpentolate
Zyklolat
Cicloplegicedol
Ciclolux
Skiacol
Cylate
EINECS 227-521-8
NSC-756706
CHEBI:4025
DTXSID9045390
UNII-736I6971TE
(+-)-cyclopentolate HCl
736I6971TE
beta-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate hydrochloride
2-(Dimethylamino)ethyl 1-hydroxy-alpha-phenylcyclopentaneacetate hydrochloride
DTXCID7025390
2-(Dimethylamino)ethyl (+-)-1-hydroxy-alpha-phenylcyclopentaneacetate hydrochloride
NSC 756706
Cyclopentolate hydrochloride [USP:JAN]
Cyclopentaneacetic acid, 1-hydroxy-alpha-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride
CYCLOMYDRIL COMPONENT CYCLOPENTOLATE HYDROCHLORIDE
2-(dimethylamino)ethyl (1-hydroxycyclopentyl)(phenyl)acetate hydrochloride
Cyclopentolate hydrochloride (USP:JAN)
CYCLOPENTOLATE HYDROCHLORIDE (MART.)
CYCLOPENTOLATE HYDROCHLORIDE [MART.]
CYCLOPENTOLATE HYDROCHLORIDE (USP-RS)
CYCLOPENTOLATE HYDROCHLORIDE [USP-RS]
CYCLOPENTOLATE HYDROCHLORIDE (EP MONOGRAPH)
CYCLOPENTOLATE HYDROCHLORIDE [EP MONOGRAPH]
CYCLOPENTOLATE HYDROCHLORIDE (USP MONOGRAPH)
CYCLOPENTOLATE HYDROCHLORIDE [USP MONOGRAPH]
CYCLOPENTOLATE HYDROCHLORIDE COMPONENT OF CYCLOMYDRIL
2-(Dimethylamino)ethyl (2RS)-2-(1-hydroxycyclopentyl)phenylacetate monohydrochloride
227-521-8
Cyclogyl
2-(Dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate hydrochloride
Cyclopentolate (hydrochloride)
CyclopentolateHCl
5870-29-1 (HCl)
MLS000069583
2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate;hydrochloride
Cyclopentolate for system suitability
SMR000058810
60452-46-2
Alnide
0UXD5V5G6V
6D6X07D6BN
Tsiklopentolat hydrochloride;Cyclogyl hydrochloride;DL-Cyclopentolate hydrochloride
Cyclopentolate hydrochloride, (+)-
Cyclopentolate hydrochloride, (-)-
60452-44-0
C17H26ClNO3
SR-01000003121
Cyclopentolate hydrochloride [JAN]
Cyclogyl (TN)
Cyclopentolate Hydrochloride; 2-(Dimethylamino)ethyl (2RS)-(1-hydroxycyclopentyl)(phenyl)acetate hydrochloride
MFCD00079048
Opera_ID_69
NCGC00016661-01
UNII-0UXD5V5G6V
2-(2-(1-Hydroxycyclopentyl)-2-phenylacetoxy)ethyldimethylammonium chloride
CAS-5870-29-1
Crimson glory rose resinoid
UNII-6D6X07D6BN
SCHEMBL24612
MLS001148637
MLS001332539
MLS001332540
SPECTRUM1500212
REGID_for_CID_22162
HY-B1621AR
Cyclopentolate HCl;AK-Pentolate
CHEMBL1200473
HY-B1621A
RHKZVMUBMXGOLL-UHFFFAOYSA-N
HMS1571K12
HMS1920A22
Pharmakon1600-01500212
BCP21337
EINECS 262-240-4
EINECS 262-242-5
Tox21_110550
CCG-39635
NSC756706
s5921
2-(Dimethylamino)ethyl (+)-(1-hydroxycyclopentyl)phenylacetate hydrochloride
AKOS015901379
Tox21_110550_1
ID58268
Benzeneacetic acid, alpha-(1-hydroxycyclopentyl)-, 2-(dimethylamino)ethyl ester, hydrochloride
Cyclopentolate hydrochloride (JP17/USP)
CYCLOPENTOLATE HYDROCHLORIDE [MI]
NCGC00018213-06
NCGC00094635-01
NCGC00094635-02
NCGC00094635-03
NCGC00094635-04
AC-27486
AS-49330
Benzeneacetic acid, alpha-(1-hydroxycyclopentyl)-, 2-(dimethylamino)ethyl ester, hydrochloride, (+-)-
Cyclopentolate (hydrochloride) (Standard)
CYCLOPENTOLATE HYDROCHLORIDE [VANDF]
DB-053247
CS-0013554
CYCLOPENTOLATE HYDROCHLORIDE [WHO-DD]
NS00087629
D01002
H10247
CYCLOPENTOLATE HYDROCHLORIDE [ORANGE BOOK]
SR-01000003121-4
Q27266147
Cyclopentolate hydrochloride, European Pharmacopoeia (EP) Reference Standard
N,N-Dimethylaminoethyl-a-(1-Hydroxycyclopentyl)phenylacetate hydrochloride
2-(Dimethylamino)ethyl (-)-(1-hydroxycyclopentyl)phenylacetate hydrochloride
2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate;hydron;chloride
2-Dimethylaminoethyl 1-hydroxy-|A-phenylcyclopentaneacetate,Cyclopentolate hydrochloride
alpha-(1-Hydroxycyclopentyl)benzeneacetic Acid 2-(Dimethylamino)ethyl Ester Hydrochloride
Cyclopentolate for system suitability, European Pharmacopoeia (EP) Reference Standard
Cyclopentolate hydrochloride, United States Pharmacopeia (USP) Reference Standard
Benzeneacetic acid, |A-(1-hydroxycyclopentyl)-, 2-(dimethylamino)ethyl ester, hydrochloride, (-)-