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Lidocaine

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Identification
Molecular formula
C14H22N2O2
CAS number
137-58-6
IUPAC name
2-(dimethylamino)ethyl 2-(4-fluorophenoxy)acetate
State
State

At room temperature, lidocaine is typically in a solid state when it is in its pure form. When formulated as a solution or ointment, it appears as a liquid.

Melting point (Celsius)
66.50
Melting point (Kelvin)
339.65
Boiling point (Celsius)
390.50
Boiling point (Kelvin)
663.65
General information
Molecular weight
234.31g/mol
Molar mass
234.3080g/mol
Density
1.0845g/cm3
Appearence

Lidocaine typically appears as a white to off-white crystalline powder. It is odorless and has a slightly bitter taste. It is soluble in water and alcohol, facilitating its use in various pharmaceutical formulations.

Comment on solubility

Solubility of 2-(dimethylamino)ethyl 2-(4-fluorophenoxy)acetate

The solubility of 2-(dimethylamino)ethyl 2-(4-fluorophenoxy)acetate is an important characteristic that is influenced by its chemical structure and functional groups. This compound typically exhibits the following solubility properties:

  • Polar Nature: The presence of the dimethylamino group increases the polarity, enhancing solubility in polar solvents like water.
  • Aromatic Character: The 4-fluorophenoxy moiety can affect the overall hydrophobicity, which may lower solubility in water but potentially improve solubility in organic solvents.
  • pH Dependence: The ionization of the amino group can lead to varying solubility at different pH levels. The compound may be more soluble in acidic conditions where the amine can be protonated.

In general, while 2-(dimethylamino)ethyl 2-(4-fluorophenoxy)acetate shows good solubility in polar solvents, the balance between its hydrophilic and hydrophobic functional groups can create notable distinctions in solubility behavior:

  • In polar solvents: It is likely soluble due to hydrogen bonding capabilities.
  • In non-polar solvents: Solubility is generally lower but may still be present to some extent.

Thus, understanding the solubility of this compound is crucial for applications in chemical synthesis and biological studies, making it a subject of interest in pharmaceutical chemistry.

Interesting facts

Interesting Facts about 2-(dimethylamino)ethyl 2-(4-fluorophenoxy)acetate

This intriguing compound, often abbreviated as a specific class of esters, possesses unique chemical properties that merit exploration. Below are some key points that highlight its significance:

  • Pharmacological Relevance: The structure of this compound enables it to interact with biological systems effectively, making it a candidate for various pharmaceutical applications.
  • Fluorine Impact: The presence of the 4-fluorophenoxy moiety enhances lipophilicity, potentially increasing the compound's ability to penetrate cell membranes, facilitating better drug delivery.
  • Dimethylamino Group: The dimethylamino substitution contributes to basicity and can influence the molecule's interaction with receptors and enzymes in the body.
  • Versatile Synthesis: This compound can be synthesized through various chemical pathways, making it an interesting subject for organic chemists interested in esterification reactions.
  • Research Applications: Beyond pharmacology, it also serves as a useful building block in organic synthesis and material science, leading to the development of new compounds.

As a student of chemistry or a seasoned scientist, understanding compounds like this one opens the door to innovative research and potential applications across multiple fields. The nuanced interactions of its functional groups make it a fascinating subject of study, demonstrating the intricate dance of molecules that underpins the world of chemistry.

Synonyms
STL300390
AKOS022110533
2-(dimethylamino)ethyl (4-fluorophenoxy)acetate